Exhaled nitric oxide in human lung transplantation: A noninvasive marker of acute rejection

American Journal of Respiratory and Critical Care Medicine

Volumn 157, Issue 6 PART I, 1998, Pages 1822-1828

  Silkoff, P E ^b   Caramori, M ^b   Tremblay, L ^b   McClean, P ^b   Chaparro, C ^b   Kesten, S ^b   Hutcheon, M ^b   Slutsky, A S ^b   Zamel, N ^b   Keshavjee, S ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; METHYLPREDNISOLONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PREDNISONE;

ACUTE DISEASE; ADULT; ARTICLE; BRONCHIOLITIS; BRONCHOSCOPY; CHEMOLUMINESCENCE; CONTROLLED STUDY; DISEASE MARKER; FEMALE; GRAFT REJECTION; HISTOLOGY; HUMAN; LUNG INFECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

EID: 0031832953     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.157.6.9707159     Document Type: Article

References (30)

1. Hosenpud, J. D., R. J. Novick, L. E. Bennet, B. M. Keck, B. Fiol, and O. Patrick Daily. 1996. The Registry of the International Society for Heart and Lung Transplantation: Thirteenth Official Report - 1996. J. Heart Lung Transplant. 15:655-674.
2. Sharples, L. D., M. Tamm, K. McNeil, T. W. Higenbottam, S. Stewart, and J. Wallwork. 1996. Development of bronchiolitis obliterans syndrome in recipients of heart-lung transplantation - early risk factors. Transplantation 61:560-566.
3. Jorens, P. G., P. A. Vermeire, and A. G. Herman. 1993. L-Arginine-dependent nitric oxide synthase: a new metabolic pathway in the lung and airways [Review]. Eur. Respir. J. 6:258-266.
4. Zapol, W. M., S. Rimar, N. Gillis, M. Marletta, and C. H. Bosken. 1994. Nitric oxide and the lung [NHLBI workshop summary]. Am. Rev. Respir. Dis. 149:1375-1380.
5. Hamid, Q., D. R. Springall, V. Riveros-Moreno, P. Chanez, P. Howarth, J. Bousquet, P. Godard, S. Holgate, and J. M. Polak. 1993. Induction of nitric oxide synthase in asthma. Lancet 342:1510-1513.
6. Tanaka, S., W. Kamiike, T. Ito, F. Uchikoshi, H. Matsuda, M. Nozawa, E. Kumura, T. Shiga, and H. Kosaka. 1995. Generation of nitric oxide as a rejection marker in rat pancreas transplantation. Transplantation 60:713-717.
7. Ohdan, H., Y. Fukuda, S. Suzuki, H. Amemiya, and K. Dohi. 1995. Simultaneous evaluation of nitric oxide synthesis and tissue oxygenation in rat liver allograft rejection using near-infrared spectroscopy. Transplantation 60:530-535.
8. Stevens, R. B., J. D. Ansite, A. Lokeh, T. J. Rossini, C. D. Mills, and D. E. Sutherland. 1995. Expression of intrahepatic inducible nitric oxide synthetase mRNA correlates with production of nitric oxide during intraportal isogeneic and allogeneic rat islet transplantation. Transplant. Proc. 27:615-616.
9. Ioannidis, I., A. Hellinger, C. Dehmlow, U. Rauen, J. Erhard, F. W. Eigler, and H. De Groot. 1995. Evidence for increased nitric oxide production after liver transplantation in humans. Transplantation 59: 1293-1297.
10. Langrehr, J. M., D. A. White, R. A. Hoffman, and R. L. Simmons. 1993. Macrophages produce nitric oxide at allograft sites. Ann. Surg. 218: 159-166.
11. Devlin, J., R. M. Palmer, C. E. Gonde, J. O'Grady, N. Heaton, K. C. Tan, J. F. Martin, S. Moncada, and R. Williams. 1994. Nitric oxide generation: a predictive parameter of acute allograft rejection. Transplantation 58:592-595.
12. Benvenuti, C., P. N. Bories, and D. Loisance. 1996. Increased serum nitrate concentration in cardiac transplant patients: a marker for acute allograft cellular rejection. Transplantation 61:745-749.
13. Barnes, P. J., and F. Y. Liew. 1995. Nitric oxide and asthmatic inflammation [Review]. Immunol. Today 16:128-130.
14. Persson, M. G., O. Zetterstrom, V. Agrenius, E. Ihre, and L. E. Gustafsson. 1994. Single-breath nitric oxide measurements in asthmatic patients and smokers. Lancet 343:146-147.
15. Kharitonov, S. A., A. U. Wells, B. J. O'Connor, P. J. Cole, D. M. Hansell, R. B. Logan-Sinclair, and P. J. Barnes. 1995. Elevated levels of exhaled nitric oxide in bronchiectasis. Ain. J. Respir. Crit. Care Med. 151:1889-1893.
16. Kharitonov, S. A., D. Yates, and P. J. Barnes. 1995. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur. Respir. J. 8:295-297.
17. Kharitonov, S. A., D. H. Yates, K. F. Chung, and P. J. Barnes. 1996. Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur. Respir. J. 9:196-201.
18. Silkoff, P. E., P. A. McClean, A. S. Slutsky, H. G. Furlott, E. Hoffstein, S. Wakita, K. R. Chapman, J. P. Szalai, and N. Zamel. 1997. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am. J. Respir. Crit. Care Med. 155:260-267.
19. Lundberg, J. O., E. Weitzberg, S. L. Nordvall, R. Kuylenstierna, J. M. Lundberg, and K. Alving. 1994. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur. Respir. J. 7:1501-1504.
20. Yousem, S. A., G. J. Berry, P. T. Cagle, D. Chamberlain, A. N. Husain, R. H. Hruban, A. Marchevsky, N. P. Ohori, J. Ritter, S. Stewart, and H. D. Tazelaar. 1996. Revision of the 1990 Working Formulation for the Classification of Pulmonary Allograft Rejection: Lung Rejection Study Group. J. Heart Lung Transplant. 15:1-15.
21. Cooper, J. D., M. Billingham, T. Egan, M. I. Hertz, T. Higgenbottam, J. Lynch, J. Maurer, I. Paradis, A. Patterson, C. Smith, E. Trulock, C. Vreim, and S. Yousem. 1993. A working formulation for the standardisation of nomenclature and for the clinical staging of chronic dysfunction in lung allografts. J. Heart Lung Transplant. 12:713-716.
22. Barnes, P. J. 1995. Nitric oxide and airway disease [Review]. Ann. Med. 27:389-393.
23. Yates, D. H., S. A. Kharitonov, P. S. Thomas, and P. J. Barnes. 1996. Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. Am. J. Respir. Crit. Care Med. 154:247-250.
24. Cai, B., D. K. Roy, R. Sciacca, R. E. Michler, and P. J. Cannon. 1995. Effects of immunosuppressive therapy on expression of inducible nitric oxide synthase (iNOS) during cardiac allograft rejection. Int. J. Cardiol. 50:243-251.
25. Worral, N. K., C. H. Boasquevisque, M. D. Botney, T. P. Misko, P. M. Sullivan, J. H. Ritter, T. Bruce Ferguson, Jr., and G. A. Patterson. 1997. Inhibition of inducible nitric oxide synthase ameliorates functional and histological changes of acute lung allograft rejection. Transplantation 63:1095-1101.
26. Gaston, B., J. M. Drazen, J. Loscalzo, and J. S. Stamler. 1994. The biology of nitrogen oxides in the airways [Review]. Am. J. Respir. Crit. Care Med. 149:538-551.
27. Winlaw, D. S., C. G. Schyvens, G. A. Smythe, Z. Y. Du, S. P. Rainer, R. S. Lord, P. M. Spratt, and P. S. MacDonald. 1995. Selective inhibition of nitric oxide production during cardiac allograft rejection causes a small increase in graft survival. Transplantation 60:77-82.
28. Mattsson, P., A. Zeevi, J. Cai, S. A. Yousem, R. Hoffman, M. Nalesnik, G. J. Burckart, D. Geller, and B. P. Griffith. 1996. Effect of aminoguanidine and cyclosporine on lung allograft rejection. Ann. Thoracic Surg. 62:207-212.
29. Worrall, N. K., K. Chang, G. M. Suau, W. S. Allison, T. P. Misko, P. M. Sullivan, R. G. Tilton, J. R. Williamson, and T. B. Ferguson, Jr. 1996. Inhibition of inducible nitric oxide synthase prevents myocardial and systemic vascular barrier dysfunction during early cardiac allograft rejection. Circ. Res. 78:769-779.
30. Kuo, P. C., E. J. Alfrey, K. Y. Abe, P. Huie, R. K. Sibley, and D. C. Dafoe. 1996. Cellular localization and effect of nitric oxide synthesis in a rat model of orthotopic liver transplantation. Transplantation 61:305-312.