Contribution of the IL-2 and IL-10 genes to inflammatory bowel disease (IBD) susceptibility

Clinical and Experimental Immunology

Volumn 113, Issue 1, 1998, Pages 28-32

  Parkes, M ^a   Satsangi, J ^a   Jewell, D ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

Crohn's disease; Genetic susceptibility; IL 10; IL 2; Ulcerative colitis

Indexed keywords

DINUCLEOTIDE; DNA; INTERLEUKIN 10; INTERLEUKIN 2;

ARTICLE; CHROMOSOME 4; CONTROLLED STUDY; CROHN DISEASE; DISEASE TRANSMISSION; DNA POLYMORPHISM; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; IMMUNOREGULATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SIBLING; ULCERATIVE COLITIS;

ALLELES; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 4; COLITIS, ULCERATIVE; CROHN DISEASE; DISEASE SUSCEPTIBILITY; GENOTYPE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-10; INTERLEUKIN-2; LINKAGE (GENETICS); MICROSATELLITE REPEATS;

EID: 0031846557     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00625.x     Document Type: Article

References (15)

1. Tysk C, Lindberg E, Järnerot G, Flodérus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988;29:990-6.
2. Probert CSJ, Jayanthi V, Hughes AO, Thompson JR, Wicks ACB, Mayberry JF. Prevalence and family risk of ulcerative colitis and Crohn's disease: an epidemiological study among Europeans and South Asians in Leicestershire. Gut 1993;34:1547-51.
3. Satsangi J, Rosenberg WMC, Jewell DP. The prevalence of inflammatory bowel disease in relatives of patients with Crohn's disease. Euro J Gastro Hepatol 1994;6:413-6.
4. McConnell RB, Vadheim CM. Inflammatory bowel disease. In: King RA, Rotter JI, Motulsky AO, eds. The genetic basis of common diseases. Oxford: Oxford University Press, 1992:326-48.
5. Neissner M, Volk BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995;101:428-35.
6. Mullin GE, Lazenby AJ. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992;102:1620-7.
7. Mullin G, Vezza FR, Sampat A. Abnormal IL-10 mRNA production in the intestinal mucosal lesions of inflammatory bowel disease. Gastroenterology 1993;104:A751.
8. Breese E, Braegger C. Interleukin-2 and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993;78:127-31.
9. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin 2 gene. Cell 1993;75:253-61.
10. Radford-Smith G, Jewell DP. Cytokines in inflammatory bowel disease. In: Allan RN, Rhodes JM, Hanauer SB, eds. Inflammatory bowel diseases, 3rd edn. London: Churchill Livingstone, 1997:95-100.
11. Kuhn RG, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin 10 deficient mice develop chronic enterocolitis. Cell 1993;75:263-74.
12. Satsangi J, Parkes M, Louis E, et al. Two-stage genome-wide search in inflammatory bowel disease: evidence for susceptibility loci on chromosomes 3, 7 and 12. Nature Genet 1996;14:199-202.
13. Terwilliger JD. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 1995;56:777-87.
14. Asakura H, Tsuchiya M, Aiso S, et al. Association of the human leukocyte DR2 antigen with Japanese ulcerative colitis. Gastroenterology 1982;82:413-8.
15. Satsangi J, Welsh KI, Bunce M, et al. Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 1996;347:1212-7.