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Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 2, 2006, Pages 252-256

Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4] benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy

(6) Masterson, Luke A a Spanswick, Victoria J b Hartley, John A b Begent, Richard H b Howard, Philip W a Thurston, David E a

a UNIVERSITY OF LONDON (United Kingdom)

b UNIVERSITY COLLEGE LONDON (United Kingdom)

Author keywords

ADEPT; CPG2; PBD; Prodrug; Pyrrolo 2,1 c 1,4 benzodiazepines

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CARBAMIC ACID DERIVATIVE; CARBOXYPEPTIDASE G2; PRODRUG; SJG 136; UNCLASSIFIED DRUG; UREA DERIVATIVE; ZD 2767 P;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; AQUEOUS SOLUTION; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME SUBSTRATE; HUMAN; HUMAN CELL;

ANTIBODIES; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GAMMA-GLUTAMYL HYDROLASE; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NITROGEN MUSTARD COMPOUNDS; PRODRUGS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 27944492682 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.10.017 Document Type: Article

Times cited : (24)

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