Different ways to induce apoptosis by fenretinide and all-trans-retinoic acid in human B lymphoma cells

Anticancer Research

Volumn 25, Issue 6 B, 2005, Pages 4179-4185

  Barna, Gábor ^a   Sebestyén, Anna ^a   Weischede, Silke ^a   Peták, István ^a   Mihalik, Rudolf ^a   Formelli, Franca ^b   Kopper, László ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

4HPR; Apoptosis; ATRA; Lymphoma; Retinoids

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE INHIBITOR; DNA FRAGMENT; ENDONUCLEASE; FENRETINIDE; REACTIVE OXYGEN METABOLITE; RETINOIC ACID;

APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CELL DEATH; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDODEOXYRIBONUCLEASES; ENZYME INHIBITORS; FENRETINIDE; HUMANS; INTRACELLULAR MEMBRANES; LYMPHOMA, B-CELL; MEMBRANE POTENTIALS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 27944491881     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Coco F, Nervi C, Avvisati G and Mandelli F: Acute promyelocytic leukemia: a curable disease. Leukemia 12: 1866-1880, 1998.
2. Reynolds CP, Matthay KK, Villablanca JG and Maurer BJ: Retinoid therapy of high-risk neuroblastoma. Cancer Lett 197: 185-192, 2003.
3. De Palo G, Mariani L, Camerini T, Marubini E, Formelli F, Pasini B, Decensi A and Veronesi U: Effect of fenretinide on ovarian carcinoma occurrence. Gynecol Oncol 86: 24-27, 2002.
4. Ohlmann CH, Jung C and Jaques G: Is growth inhibition and induction of apoptosis in lung cancer cell lines by fenretinide [N-(4-hydroxyphenyl) retinamide] sufficient for cancer therapy? Int J Cancer 100: 520-526, 2002.
5. Kalemkerian GP, Jiroutek M, Ettinger DS, Dorighi JA, Johnson DH and Mabry M: A phase II study of all-trans-retinoic acid plus cisplatin and etoposide in patients with extensive stage small cell lung carcinoma: an Eastern Cooperative Oncology Group Study. Cancer 83: 1102-1108, 1998.
6. Levi MS, Borne RF and Williamson JS: A review of cancer chemopreventive agents. Curr Med Chem 8: 1349-1362, 2001.
7. Moon RC, Metha RG and Rao KVN: Retinoids and cancer in experimental animals. In: Sporn MB, Roberts AB and Goodman DS (eds.). The Retinoids: Biology, Chemistry and Medicine. 2nd Edition New York: Raven Press Ltd., pp. 573-595, 1994.
8. Formell F and Cleris L: Synthetic retinoid fenretinide is effective against a human ovarian carcinoma xenograft and potentiates cisplatin activity. Cancer Res 53: 5374-5376, 1993.
9. Simeone AM, Ekmekcioglu S, Broemeling LD, Grimm EA and Tari AM: A novel mechanism by which N-(4-hydroxyphenyl) retinamide inhibits breast cancer cell growth: the production of nitric oxide. Mol Cancer Ther 1: 1009-1017, 2002.
10. Erratum in: Mol Cancer Ther 1: 1366, 2002.
11. Pergolizzi R, Appierto V, Crosti M, Cavadini E, Cleris L, Guffanti A and Formelli F: Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells. Int J Cancer 81: 829-834, 1999.
12. Faderl S, Lotan R, Kantarjian HM, Harris D, Van Q and Estrov Z: N-(4-Hydroxylphenyl) retinamide (fenretinide, 4-HPR), a retinoid compound with antileukemic and proapoptotic activity in acute lymphoblastic leukemia (ALL). Leuk Res 27: 259-266, 2003.
13. Lovat PE, Ranalli M, Annichiarrico-Petruzzelli M, Bernassola F, Piacentini M, Malcolm AJ, Pearson AD, Melino G and Redfern CP: Effector mechanisms of fenretinide-induced apoptosis in neuroblastoma. Exp Cell Res 260: 50-60, 2000.
14. Delia D, Aiello A, Lombardi L, Pelicci PG, Grignani F, Grignani F, Formelli F, Menard S, Costa A, Veronesi U et al: N-(4-hydroxyphenyl) retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid. Cancer Res 53: 6036-6041, 1993.
15. Zheng A, Mantymaa P, Saily M, Siitonen T, Savolainen ER and Koistinen P: An association between mitochondrial function and all-trans retinoic acid-induced apoptosis in acute myeloblastic leukaemia cells. Br J Haematol 105: 215-224, 1999.
16. Boya P, Morales MC, Gonzalez-Polo RA, Andreau K, Gourdier I, Perfettini JL, Larochette N, Deniaud A, Baran-Marszak F, Fagard R, Feuillard J, Asumendi A, Raphael M, Pau B, Brenner C and Kroemer G: The chemopreventive agent N-(4-hydroxyphenyl) retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family. Oncogene 22: 6220-6230, 2003.
17. Notario B, Zamora M, Vinas O and Mampel T: All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition. Mol Pharmacol 63: 224-231, 2003.
18. Asumendi A, Morales MC, Alvarez A, Arechaga J and Perez-Yarza G: Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis. Br J Cancer 86: 1951-1956, 2002.
19. Kopper L, Bankfalvi A, Mihalik R, Nagy P, Fulop C and Sarmay G: New in vitro line from a human (B) non-Hodgkin lymphoma. Anticancer Res 11: 1645-1649, 1991.
20. Lopez-Hernandez FJ, Ortiz MA, Bayon Y and Piedrafita FJ: Reduced concentrations of serum enhance the antiproliferative activity of retinoid-related molecules and accelerate the onset of apoptosis. Biochem Pharmacol 65: 2021-2030, 2003.
21. Potokar M, Milisav I, Kreft M, Stenovec M and Zorec R: Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria. FEBS Lett 544: 153-159, 2003.
22. Gong J, Traganos F and Darzynkiewicz Z: A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem 218: 314-319, 1994.
23. Inre G and Mihalik R: To kill two birds with one stone: simultaneous detection of apoptosis and necrosis in ethanol fixed cells by flow cytometry. Cytometry 59A: 116-117, 2004.
24. Barna G, Sebestyen A, Chinopoulos CC, Nagy K, Mihalik R, Paku S and Kopper L: TGF beta 1 kills lymphoma cells using mitochondrial apoptotic pathway with the help of caspase-8. Anticancer Res 22: 3867-3872, 2002.
25. Delia D, Aiello A, Meroni L, Nicolini M, Reed JC and Pierotti MA: Role of antioxidants and intracellular free radicals in retinamide-induced cell death. Carcinogenesis 18: 943-948, 1997.
26. Chen Q, Chai YC, Mazumder S, Jiang C, Macklis RM, Chisolm GM and Almasan A: The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction. Cell Death Differ 10: 323-334, 2003.
27. Eskes R, Desagher S, Antonsson B and Martinou JC: Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol 20: 929-935, 2000.
28. Li H, Zhu H, Xu CJ and Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501, 1998.
29. Heinrich M, Neumeyer J, Jakob M, Hallas C, Tchikov V, Winoto-Morbach S, Wickel M, Schneidert-Brachert W, Trauzold A, Hethke A and Schutze S: Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ 11: 550-563, 2004.
30. Mandic A, Viktorsson K, Strandberg L, Heiden T, Hansson J, Linder S and Shoshan MC: Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol 22: 3003-3013, 2002.
31. Leist M, Single B, Castoldi AF, Kuhnle S and Nicotera P: Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 185: 1481-1486, 1997.
32. Wang KK: Calpain and caspase: can you tell the difference? Trends Neurosci 23: 20-26, 2000.
33. Shan D, Gopal AK and Press OW: Synergistic effects of the fenretinide (4-HPR) and anti-CD20 monoclonal antibodies on apoptosis induction of malignant human B cells. Clin Cancer Res 7: 2490-2495, 2001.
34. Festjens N, van Gurp M, van Loo G, Saelens X and Vandenabeele P: Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death. Acta Haematol 111: 7-27, 2004.
35. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM and Kroemer G: Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446, 1999.
36. van Loo G, Schotte P, van Gurp M, Demol H, Hoorelbeke B, Gevaert K, Rodriguez I, Ruiz-Carrillo A, Vandekerckhove J, Declercq W, Beyaert R and Vandenabeele P: Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ 8: 1136-1142, 2001.
37. Shinozawa I, Inokuchi K, Wakabayashi I and Dan K: Disturbed expression of the anti-apoptosis gene, survivin, and EPR-1 in hematological malignancies. Leuk Res 24: 965-970, 2000.