TGFβ1 kills lymphoma cells using mitochondrial apoptotic pathway with the help of caspase-8

Anticancer Research

Volumn 22, Issue 6 C, 2002, Pages 3867-3872

  Barna, Gabor ^a   Sebestyén, Anna ^a   Chinopoulos, Christos C ^a   Nagy, Katalin ^a   Mihalik, Rudolf ^b   Paku, Sandor ^b   Kopper, Laszlo ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Apoptosis; Bax; Bid; Caspase 8; Lymphoma; TGF 1; TIEG

Indexed keywords

CASPASE 3; CASPASE 8; PROTEIN BAX; PROTEIN BID; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CATALYSIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOMA CELL; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION;

APOPTOSIS; CASPASE 8; CASPASE 9; CASPASES; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; INTRACELLULAR MEMBRANES; LYMPHOMA, B-CELL; MEMBRANE POTENTIALS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0036875351     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Attisano L, Silvestri C, Izzi L and Labbe E: The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling. Mol Cell Endocrinol 180: 3-11, 2001.
2. Derynck R, Akhurst RJ and Balmain A: TGFβ signalling in tumor suppression and cancer progression. Nature Genet 29: 117-129, 2001.
3. Lotz M, Ranheim E and Kipps TJ: Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J Exp Med 179: 999-1004, 1994.
4. Tótth A, Sebestyén A, Barna G, Nagy K, Göndör A, Bocsi J, Mihalik R, Petak I, Houghton J and Kopper L: TGFβ1 induces caspase-dependent but death-receptor independent apoptosis in lymphoid cells. Anticancer Res 21: 1207-1212, 2001.
5. Herrera B, Alvarez AM, Sanchez A, Fernandez M, Roncero C, Benito M and Fabregat I: Reactive oxigen species (ROS) mediates the mitochondrial dependent apoptosis induced by transforming growth factor β in fetal hepatocytes. FASEB J 15: 741-751, 2001.
6. Kopper L, Bánkfalvi Á, Mihalik R, Nagy P, Fülöp Cs and Sármay G: New in vitro line from human (B) non-Hodgkin lymphoma. Anticancer Res 11: 1645-1651, 1991.
7. Gong J, Traganos F and Darzynkievicz Z: A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem 218: 314-319, 1994.
8. Telek G, Scoazec JY, Chariot J, Ducroc R, Feldmann G and Roz C: Cerium-based histochemical demonstration of oxidative stress in taurocholate-induced acute pancreatitis in rats. A confocal laser scanning microscopic study. J Histochem Cytochem 47: 1201-1212, 1999.
9. Lee RH, Song JM, Park MY, Kang SK, Kim YK and Jung JS: Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells. Biochem Pharmacol 62: 1013-1023, 2001.
10. Eskes R, Desagher S, Antonssai B and Martinou JC: Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol 20: 929-935, 2000.
11. 2 - generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1. J Biol Chem 270: 334-338, 1996.
12. Kayanoki Y, Fujii J, Suzuki K, Kawata S, Matsuzawa Y and Taniguchi N: Suppression of antioxidative enzyme expression by transforming growth factor-beta 1 in rat hepatocytes. J Biol Chem. 269: 15488-15492, 1994.
13. Nagy P, Török N, Ladányi A and Kopper L: Expression of transforming growth factor-beta in human non-Hodgkin's lymphoma xenografts. J Natl Cancer Inst 83: 1174-1175, 1991.
14. Kroemer G: Mitochondrial control of apoptosis: an overview. Biochem Soc Symp 66: 1-15, 1999.
15. Chao DT and Korsmeyer J: BCL-2 family: regulators of cell death. J Annu Rev Immunol 16: 395-419, 1998.
16. Chipuk JE, Bhat M, Hsing AY, Ma J and Danielpour D: Bcl-XL blocks transforming growth factor-beta-1 induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells. J Biol Chem 276: 26614-26621, 2001.
17. Francis JM, Heyworth CM, Spooncer E, Pierce A, Dexter TM and Whetton AD: Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells. J Biol Chem 275: 39137-39145, 2000.
18. Motyl T, Gajkowska B, Ploszaj T, Wareski P, Skierski J and Zimowska W: Expression and subcellular redistribution of Bax during TGF-beta1-induced programmed cell death of HC11 mouse mammary epithelial cells. Cell Mol Biol 46: 175-185, 2000.
19. Krammer PH: CD95's deadly mission in the immune system. Nature 407: 789-795, 2000.
20. Ribeiro A, Bronk SF, Roberts PJ, Urrutia R and Gores GJ: The transforming growth factor beta(1)-inducible transrciption TIEG1, mediates apoptosis through oxidative stress. Hepatology 30: 1490-1497, 1999.
21. Sebestyen A, Barna G, Nagy K, Jánosi J, Paku S, Bocsi J, Berczi L, Mihalik R and Kopper L: A classical and alternative signaling pathways in TGFβ1 induced apoptosis of lymphoma cells. Int J Cancer (submitted for publication).