Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase

Cell Research

Volumn 15, Issue 9, 2005, Pages 717-724

  Zhang, Fan ^a   Chen, Chun Lian ^a   Qian, Jia Qing ^a   Yan, Jiang Tao ^a   Cianflone, Katherine ^b   Xiao, Xiao ^c   Wang, Dao Wen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

20 Hydroxyeicosatetraenoic acids; Arachidonic acid; Cytochrome P450 4A1; Hypertension; Recombinant adeno associated virus; Spontaneously hypertensive rats

Indexed keywords

20 HYDROXY 5,8,11,14 EICOSATETRAENOIC ACID; 20-HYDROXY-5,8,11,14-EICOSATETRAENOIC ACID; COMPLEMENTARY DNA; CYP4A22 PROTEIN, RAT; CYTOCHROME P450; HYDROXYICOSATETRAENOIC ACID; ISOPROTEIN; MESSENGER RNA; RNA;

ADENO ASSOCIATED VIRUS; ANIMAL; ARTICLE; BLOOD PRESSURE; CHEMISTRY; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; HYPERTENSION; KIDNEY; LIVER; MALE; METABOLISM; METHODOLOGY; MOLECULAR CLONING; NORTHERN BLOTTING; PHYSIOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT; SYSTOLE; TIME; WESTERN BLOTTING;

ANIMALS; BLOOD PRESSURE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; DEPENDOVIRUS; DNA, COMPLEMENTARY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HYDROXYEICOSATETRAENOIC ACIDS; HYPERTENSION; KIDNEY; LIVER; MALE; PROTEIN ISOFORMS; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RNA; RNA, MESSENGER; SYSTOLE; TIME FACTORS;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 27944466163     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cr.7290341     Document Type: Article

References (37)

1. McGiff JC, Quilley J. 20-HETE and the kidney: resolution of old problems and new beginnings. Am J Physiol Regul Integr Comp Physiol 1999; 277:R607-23.
2. Schwartzman ML, da Silva JL, Lin F, Nishimura M, Abraham NG. Cytochrome P450 4A expression and arachidonic acid omega-hydroxylation in the kidney of the spontaneously hypertensive rat. Nephron 1996; 73:652-63.
3. Schwartzman M, Carroll MA, Ibraham NG, et al. Renal arachidonic acid metabolism. The third pathway. Hypertension 1985; 7(3 Pt 2):I136-44.
4. Zeldin DC. Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem 2001; 276:36059-62.
5. Makita K, Falck JR, Capdevila JH. Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system. Faseb J 1996; 10:1456-63.
6. Ma YH, Schwartzman ML, Roman RJ. Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol 1994; 267(2 Pt 2):R579-89.
7. Wilson TW, Alonso-Galicia M, Roman RJ. Effects of lipid-lowering agents in the Dahl salt-sensitive rat. Hypertension 1998; 31(1 Pt 2):225-31.
8. Roman RJ, Alonso-Galicia M, Wilson TW. Renal P450 metabolites of arachidonic acid and the development of hypertension in Dahl salt-sensitive rats. Am J Hypertens 1997; 10(5 Pt 2): S63-7.
9. Omata K, Abraham NG, Escalante B, Schwartzman ML. Age-related changes in renal cytochrome P-450 arachidonic acid metabolism in spontaneously hypertensive rats. Am J Physiol Renal Physiol 1992; 262:F8-16.
10. Sacerdoti D, Abraham NG, McGiff JC, Schwartzman ML. Renal cytochrome P-450-dependent metabolism of arachidonic acid in spontaneously hypertensive rats. Biochem Pharmacol. 1988; 37:521-7.
11. Su P, Kaushal KM, Kroetz DL. Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. Am J Physiol Regul Integr Comp Physiol 1998; 275(2 Pt 2):R426-38.
12. Wang MH, Zand BA, Nasjletti A, Laniado-Schwartzman M. Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy. Am J Physiol Regul Integr Comp Physiol 2002; 282: R383-9.
13. Zhang F, Qian JQ, Wang DW. Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure. Acta Pharmacol Sin 2002; 23:497-502.
14. Wang DW, Zhang F, Qian JQ. Contribution of cytochrome P450 4a1 to the long term control of arterial blood pressure: evidence from somatic CYP 4a1 gene modidications. FASEB J 2002; 16: A486 (abstract).
15. Wang MH, Zhang F, Marji J, Zand BA, Nasjletti A, Laniado-Schwartzman M. CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR. Am J Physiol Regul Integr Comp Physiol 2001; 280:R255-261.
16. Kimura S Hardwick JP, Kozak CA, Gonzalez FJ. The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. DNA 1989; 8:503-16.
17. Xiao X, Li J, Samulski RJ. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol 1998; 72:2224-32.
18. Monahan PE, Samulski RJ. Adeno-associated virus vectors for gene therapy: more pros than cons? Mol Med Today 2000; 6: 433-40.
19. Xiao X, Li J, Samulski R. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol 1996; 70:8098-108.
20. Auricchio A, Hildinger M, O'Connor E, Gao GP, Wilson JM. Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column. Hum Gene Ther 2001; 12:71-6.
21. Wang J, Xiong W, Yang Z, et al. Human tissue kallikrein induces hypotension in transgenic mice. Hypertension 1994; 23:236-43.
22. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-54.
23. Nguyen X, Wang MH, Reddy KM, Falck JR, Schwartzman ML. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Am J Physiol Regul Integr Comp Physiol 1999; 276:R1691-700.
24. Wang MH, Wang J, Chang HH, et al. Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats. Am J Physiol Renal Physiol 2003; 285:F295-302.
25. Zou AP, Fleming JT, Falck JR, et al. 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol Regul Integr Comp Physiol 1996; 270:R228-237.
26. Lange A, Gebremedhin D, Narayanan J, Harder D. 20-Hydroxyeicosatetraenoic Acid-induced Vasoconstriction and Inhibition of Potassium Current in Cerebral Vascular Smooth Muscle Is Dependent on Activation of Protein Kinase C. J Biol Chem 1997; 272:27345-52.
27. Imig JD, Zou AP, Stec DE, et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am J Physiol Regul Integr Comp Physiol 1996; 270:R217-27.
28. Ito O, Alonso-Galicia M, Hopp KA, Roman RJ. Localization of cytochrome P-450 4A isoforms along the rat nephron. Am J Physiol Renal Physiol 1998; 274:F395-404.
29. Escalante B, Erlij D, Falck JR, McGiff JC. Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle. Science. 1991; 251:799-802.
30. Alonso-Galicia M, Frohlich B, Roman RJ. Induction of P4504A activity improves pressure-natriuresis in Dahl S rats. Hypertension 1998; 31(1 Pt 2):232-6.
31. Shatara RK, Quest DW, Wilson TW. Fenofibrate lowers blood pressure in two genetic models of hypertension. Can J Physiol Pharmacol 2000; 78:367-71.
32. Wang T, Li H, Zhao C, et al. Recombinant adeno-associated virus-mediated kallikrein gene therapy reduces hypertension and attenuates its cardiovascular injuries. Gene Ther 2004; 11:1342-50.
33. Gunzl A, Palfi Z, Bindereif A. Analysis of RNA-protein complexes by oligonucleotide-targeted RNase H digestion. Methods 2002; 26:162-9.
34. Zhao X, Imig JD. Kidney CYP450 enzymes: biological actions beyond drug metabolism. Curr Drug Metab 2003; 4:73-84.
35. Escalante BA, McGiff JC, Oyekan AO. Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule. Am J Physiol Renal Physiol 2002; 282:F144-150.
36. Carroll MA, Kemp R, Cheng MK, McGiff JC. Regulation of preglomerular microvascular 20-hydroxyeicosatetraenoic acid levels by salt depletion. Med Sci Monit 2001; 7:567-72.
37. Oyekan AO, McAward K, Conetta J, Rosenfeld L, McGiff JC. Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension. Am J Physiol Regul Integr Comp Physiol 1999; 276(3 Pt 2): R766-75.