Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene

Annals of the New York Academy of Sciences

Volumn 1037, Issue , 2004, Pages 193-198

  Nakayama, Maki ^a   Moriyama, Hiroaki ^a   Abiru, Norio ^a   Babu, Sunanda R ^a   Sikora, Kamila ^a   Li, Marcella ^a   Miao, Dongmei ^a   Hutton, John C ^a   Elliott, John F ^b   Eisenbarth, George S ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Autoimmunity; Diabetes; Insulin; Insulin gene

Indexed keywords

ALANINE; EPITOPE; GENE PRODUCT; INSULIN; INSULIN B; PREPROINSULIN; PRIMER DNA; TYROSINE; UNCLASSIFIED DRUG;

ADOLESCENT; AMINO ACID SUBSTITUTION; ANIMAL MODEL; CONFERENCE PAPER; FEMALE; FOUNDER EFFECT; GENETIC CROSS; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; KNOCKOUT GENE; KNOCKOUT MOUSE; MALE; MOUSE; NATIVE INSULIN NEGATIVE NOD MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN MODIFICATION; T LYMPHOCYTE; TRANSGENE; TRANSGENIC MOUSE;

EID: 20044390925     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1337.031     Document Type: Conference Paper

References (7)

1. DANIEL, D., R.G. GILL, N. SCHLOOT, et al. 1995. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur. J. Immunol. 25: 1056-1062.
2. WONG, F.S., J. KARTTUNEN, C. DUMONT, et al. 1999. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat. Med. 5: 1026-1031.
3. MORIYAMA, H., N. ABIRU, J. PARONEN, et al. 2003. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the NOD mouse. Proc. Natl. Acad. Sci. USA 100: 10376-10381.
4. ALLEVA, D.G., A. GAUR, L. JIN, et al. 2002. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 51: 2126-2134.
5. PARONEN, J., H. MORIYAMA, N. ABIRU, et al. 2003. Establishing insulin 1 and insulin 2 knockout congenic strains on NOD genetic background. Ann. N.Y. Acad. Sci. 1005: 205-210.
6. EISENBARTH, G.S. & J. JASINSKI. 2004. Disease prevention with islet autoantigens. Endocrinol. Metab. Clin. North Am. 33: 59-74.
7. MORIYAMA, H., L. WEN, N. ABIRU, et al. 2002. Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc. Natl. Acad. Sci. USA 99: 5539-5544.