Androgen receptor and TGFbeta1/Smad signaling are mutually inhibitory in prostate cancer

European Urology

Volumn 48, Issue 6, 2005, Pages 1051-1058

  Van Der Poel, H G ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Androgen receptor; Prostate cancer; Smad; TGFbeta1

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; LUCIFERASE; MYC PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; ASSAY; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; CYTOCHEMISTRY; FLOW CYTOMETRY; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RECEPTOR GENE; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STAINING; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

APOPTOSIS; DIHYDROTESTOSTERONE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; MALE; NEOPLASMS, HORMONE-DEPENDENT; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 27844610897     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2005.09.006     Document Type: Article

References (21)

1. M.E. Taplin, B. Rajeshkumar, S. Halabi, C.P. Werner, B.A. Woda, and J. Picus Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663 J Clin Oncol 21 2003 2673 2678
2. M.J. Linja, K.J. Savinainen, O.R. Saramaki, T.L. Tammela, R.L. Vessella, and T. Visakorpi Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer Cancer Res 61 2001 3550 3555
3. C.D. Chen, D.S. Welsbie, C. Tran, S.H. Baek, R. Chen, and R. Vessella Molecular determinants of resistance to antiandrogen therapy Nat Med 10 2004 33 39
4. D. Danielpour Functions and regulation of transforming growth factor-beta (TGF-beta) in the prostate Eur J Cancer 41 2005 846 857
5. M.W. Kattan, S.F. Shariat, B. Andrews, K. Zhu, E. Canto, and K. Matsumoto The addition of interleukin-6 soluble receptor and transforming growth factor beta1 improves a preoperative nomogram for predicting biochemical progression in patients with clinically localized prostate cancer J Clin Oncol 21 2003 3573 3579
6. H.G. van der Poel Mammalian target of rapamycin and 3- phosphatidylinositol 3-kinase pathway inhibition enhances growth inhibition of transforming growth factor-beta1 in prostate cancer cells J Urol 172 2004 1333 1337
7. J.E. Chipuk, S.C. Cornelius, N.J. Pultz, J.S. Jorgensen, M.J. Bonham, and S.J. Kim The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3 J Biol Chem 277 2002 1240 1248
8. H.Y. Kang, K.E. Huang, S.Y. Chang, W.L. Ma, W.J. Lin, and C. Chang Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4 J Biol Chem 277 2002 43749 43756
9. K. Ellwood-Yen, T.G. Graeber, J. Wongvipat, M.L. Iruela-Arispe, J. Zhang, and R. Matusik Myc-driven murine prostate cancer shares molecular features with human prostate tumors Cancer Cell 4 2003 223 238
10. D. Bernard, A. Pourtier-Manzanedo, J. Gil, and D.H. Beach Myc confers androgen-independent prostate cancer cell growth J Clin Invest 112 2003 1724 1731
11. Y. Guo, and N. Kyprianou Overexpression of transforming growth factor (TGF) beta1 type II receptor restores TGF-beta1 sensitivity and signaling in human prostate cancer cells Cell Growth Differ 9 1998 185 193
12. A.O. Brinkmann, P.W. Faber, H.C. van Rooij, G.G. Kuiper, C. Ris, and P. Klaassen The human androgen receptor: domain structure, genomic organization and regulation of expression J Steroid Biochem 34 1989 307 310
13. S.A. Hayes, M. Zarnegar, M. Sharma, F. Yang, D.M. Peehl, and P. ten Dijke SMAD3 represses androgen receptor-mediated transcription Cancer Res 61 2001 2112 2118
14. H.L. Adler, M.A. McCurdy, M.W. Kattan, T.L. Timme, P.T. Scardino, and T.C. Thompson Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma J Urol 161 1999 182 187
15. S.F. Shariat, A. Menesses-Diaz, I.Y. Kim, M. Muramoto, T.M. Wheeler, and K.M. Slawin Tissue expression of transforming growth factor-beta1 and its receptors: correlation with pathologic features and biochemical progression in patients undergoing radical prostatectomy Urology 63 2004 1191 1197
16. I.Y. Kim, H.J. Ahn, D.J. Zelner, J.W. Shaw, S. Lang, and M. Kato Loss of expression of transforming growth factor beta type I and type II receptors correlates with tumor grade in human prostate cancer tissues Clin Cancer Res 2 1996 1255 1261
17. M.E. McMenamin, P. Soung, S. Perera, I. Kaplan, M. Loda, and W.R. Sellers Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage Cancer Res 59 1999 4291 4296
18. P. Wikstrom, P. Westin, P. Stattin, J.E. Damber, and A. Bergh Early castration-induced upregulation of transforming growth factor beta1 and its receptors is associated with tumor cell apoptosis and a major decline in serum prostate-specific antigen in prostate cancer patients Prostate 38 1999 268 277
19. J.P. Frederick, N.T. Liberati, D.S. Waddell, Y. Shi, and X.F. Wang Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element Mol Cell Biol 24 2004 2546 2559
20. C.S. Foster, A. Falconer, A.R. Dodson, A.R. Norman, N. Dennis, and A. Fletcher Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome Oncogene 23 2004 5871 5879
21. K. Tomari, T. Kumagai, T. Shimizu, and K. Takeda Bone morphogenetic protein-2 induces hypophosphorylation of Rb protein and repression of E2F in androgen-treated LNCaP human prostate cancer cells Int J Mol Med 15 2005 253 258