New synthetic approach to the bicyclo[3.1.0]hexane ring system from(+)-(1R,4R)-4-(Benzyloxymethyl)-4-(hydroxymethyl)cyclopent-2-enol

Bulletin of the Korean Chemical Society

Volumn 26, Issue 10, 2005, Pages 1503-1504

  Kim, Soon Ai ^a   Jacobson, Kenneth A ^b   Hak, Sung Kim ^a  

^a Wonkwang University   (South Korea)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Adenosine receptor agonists; Antagonists; Bicyclo 3.1.0 hexane; Northern nucleoside

Indexed keywords

EID: 27844586428     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2005.26.10.1503     Document Type: Article

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18. 3) δ 7.26-7.40 (m, 5H), 4.57 (s, 2H), 4.50 (AB quartet, 2H, J = 4.5 Hz), 4.29 (d, 1H, J = 9.2Hz), 4.13 (d, 1H, J = 9.2Hz), 4.11 (m, 1H), 3.66 (d, 1H, J = 9.2 Hz), 3.57 (d, 1H, J = 9.2 Hz), 2.98 (s, 3H), 2.06 (dd, 1H, J = 6.4, 14.7 Hz), 1.69 (d, 1H, J = 14.7 Hz), 1.42 (s, 3H), 1.26 (s, 3H).
19. 3) δ 7.18-7.37 (m, 5H), 4.57 (d, 1H, J = 4.5 Hz), 4.47 (AB quartet, 2H, J = 11.1 Hz), 4.40 (d, 1H, J = 10.0 Hz), 4.40 (m, 1H), 4.29 (d, 1H, J = 10.0 Hz), 3.66 (d, 1H, J = 9.0 Hz), 3.44 (d, 1H, J = 9.0 Hz), 2.57 (s, 3H), 2.44 (d, 1H, J = 17.5 Hz), 2.22 (d, 1H, J = 17.5 Hz), 1.42 (s, 3H), 1.32 (s, 3H).
20. Kojima, K.; Amemiya, S.; Saito, S. Chem. Pharm. Bull. 1987, 35, 948.
21. 3) δ 204.85, 137.83, 128.61 (two carbons on phenyl ring), 128.00, 127.86 (two carbons on phenyl ring), 114.80, 79.53, 73.25, 71.06, 36.52, 36.15, 25.75, 24.20, 16.64.