New cohorts of naive T cells exacerbate ongoing allergy but can be suppressed by regulatory T cells

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 60, Issue 12, 2005, Pages 1530-1536

  Hauet Broere, F ^a,b,c   Unger, W W J ^a,d   Van Berkel, L A ^a,e   Garssen, J ^b   Hoijer, M A ^b   Kraal, G ^a   Samsom, Janneke N ^a,e  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NUMICO RESEARCH   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Mucosa; Naive T cells; Regulatory T cells; Suppression; Tolerance

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE EXACERBATION; IMMUNOLOGICAL TOLERANCE; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; HYPERSENSITIVITY; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MUCOUS MEMBRANE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 27844583430     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2005.00925.x     Document Type: Article

References (26)

1. Faria AM, Weiner HL. Oral tolerance: mechanisms and therapeutic applications. Adv Immunol 1999;73:153-264.
2. Mayer L, Shao L. Therapeutic potential of oral tolerance. Nat Rev Immunol 2004;4:407-419.
3. Husby S, Mestecky J, Moldoveanu Z, Holland S, Elson CO. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. J Immunol 1994;152:4663-4670.
4. Kraus TA, Toy L, Chan L, Childs J, Mayer L. Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology 2004;126:1771-1778.
5. Patriarca G, Nucera E, Roncallo C, Pollastrini E, Bartolozzi F, De Pasquale T et al. Oral desensitizing treatment in food allergy: clinical and immunological results. Aliment Pharmacol Ther 2003;17:459-465.
6. Ngan J, Kind LS. Suppressor T cells for IgE and IgG in Peyer's patches of mice made tolerant by the oral administration of ovalbumin. J Immunol 1978;120:861-865.
7. Hauet-Broere F, Unger WW, Garssen J, Hoijer MA, Kraal G, Samsom JN. Functional CD25- and CD25+ mucosal regulatory T cells are induced in gut-draining lymphoid tissue within 48 h after oral antigen application. Eur J Immunol 2003;33:2801-2810.
8. Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4+ CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy. J Exp Med 2004;199:1679-1688.
9. van Halteren AG, van der Cammen MJ, Biewenga J, Savelkoul HF, Kraal G. IgE and mast cell response on intestinal allergen exposure: a murine model to study the onset of food allergy. J Allergy Clin Immunol 1997;99:94-99.
10. Badovinac VP, Messingham KA, Hamilton SE, Harty JT. Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host. J Immunol 2003;170:4933-4942.
11. Akbar AN, Salmon M, Janossy G. The synergy between naive and memory T cells during activation. Immunol Today 1991;12:184-188.
12. Kearney ER, Pape KA, Loh DY, Jenkins MK. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1994;1:327-339.
13. Unger WW, Hauet-Broere F, Jansen W, van Berkel LA, Kraal G, Samsom JN. Early events in peripheral regulatory T cell induction via the nasal mucosa. J Immunol 2003;171:4592-4603.
14. Lambrecht BN, Pauwels RA, Fazekas De St Groth B. Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model. J Immunol 2000;164:2937-2946.
15. Deenick EK, Gett AV, Hodgkin PD. Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival. J Immunol 2003;170:4963-4972.
16. Banyer JL, Halliday DC, Thomson SA, Hamilton NH. Combinations of IFN-gamma and IL-4 induce distinct profiles of dendritic cell-associated immunoregulatory properties. Genes Immun 2003;4:427-440.
17. Unger WW, Jansen W, Wolvers DA, van Halteren AG, Kraal G, Samsom JN. Nasal tolerance induces antigen-specific CD4+ CD25- regulatory T cells that can transfer their regulatory capacity to naive CD4+ T cells. Int Immunol 2003;15:731-739.
18. Lanzavecchia A, Sallusto F. Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science 2000;290:92-97.
19. Hug A, Korporal M, Schroder I, Haas J, Glatz K, Storch-Hagenlocher B et al. Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis. J Immunol 2003;171:432-437.
20. Wagner UG, Koetz K, Weyand CM, Goronzy JJ. Perturbation of the T cell repertoire in rheumatoid arthritis. Proc Natl Acad Sci U S A 1998;95:14447-14452.
21. Berzins SP, Uldrich AP, Sutherland JS, Gill J, Miller JF, Godfrey DI et al. Thymic regeneration: teaching an old immune system new tricks. Trends Mol Med 2002;8:469-476.
22. Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002;195:603-616.
23. Chen Y, Inobe J, Weiner HL. Inductive events in oral tolerance in the TCR transgenic adoptive transfer model. Cell Immunol 1997;178:62-68.
24. Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH. Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 2002;196:255-260.
25. Mason D, Powrie F. Control of immune pathology by regulatory T cells. Curr Opin Immunol 1998;10:649-655.
26. Akdis CA, Blaser K, Akdis M. Genes of tolerance. Allergy 2004;59:897-913.