Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt

Free Radical Biology and Medicine

Volumn 39, Issue 12, 2005, Pages 1549-1559

  Kaimul Ahsan, M ^a   Nakamura, Hajime ^b   Tanito, Masaki ^a   Yamada, Kenichi ^c   Utsumi, Hideo ^c   Yodoi, Junji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Diesel exhaust particles; Free radicals; Lung injury; Noninvasive L band electron spin resonance; Reactive oxygen species; Thioredoxin 1

Indexed keywords

DIESEL FUEL; HYDROXYL RADICAL; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN; SCAVENGER; THIOREDOXIN; THIOREDOXIN 1; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ELECTRON SPIN RESONANCE; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EXHAUST GAS; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY INFILTRATE; LUNG INJURY; LUNG TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL LINE; DOWN-REGULATION; FEMALE; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; HUMANS; HYDROXYL RADICAL; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PARTICLE SIZE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; THIOREDOXIN; VEHICLE EMISSIONS;

ANIMALIA; MUS MUSCULUS;

EID: 27844518302     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.07.016     Document Type: Article

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