Protein C Sapporo (protein C Glu 25 → Lys): A heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor

Thrombosis and Haemostasis

Volumn 94, Issue 5, 2005, Pages 942-950

  Nakabayashi, Toru ^a   Mizukami, Kazuhiro ^a   Naitoh, Sumiyoshi ^a   Takeda, Mika ^a   Shikamoto, Yasuo ^b   Nakagawa, Takafumi ^b   Kaneko, Hiroki ^c   Tarumi, Takashi ^a   Mizoguchi, Itaru ^a   Mizuno, Hiroshi ^b   Ieko, Masahiro ^a   Koike, Takao ^d  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b NEC CORPORATION   (Japan)

^c NIHON UNIVERSITY   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

EPCR (endothelial protein C receptor); Gla domain ( carboxyglutamic acid domain); Protein C deficiency; Protein C Sapporo; Type IIb deficiency

Indexed keywords

4 CARBOXYGLUTAMIC ACID; ALANINE; AMINO ACID; ANTIGEN; ENDOTHELIAL PROTEIN C RECEPTOR; GLUTAMINE; GLYCINE; LYSINE; MEMBRANE PHOSPHOLIPID; NUCLEOTIDE; PROTEIN C; PROTEIN C SAPPORO; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; WATER;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BIOASSAY; CASE REPORT; COMPLEX FORMATION; EXON; FEMALE; GENE SEQUENCE; HETEROZYGOSITY; HUMAN; HUMAN CELL; JAPAN; MALE; MISSENSE MUTATION; MOLECULAR DYNAMICS; MOTHER; PHENOTYPE; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROGENY; PROTEIN C DEFICIENCY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECURRENT DISEASE; SEQUENCE ANALYSIS; SIMULATION; THROMBOEMBOLISM;

ADULT; ANTIGENS; ANTIGENS, CD; BLOOD COAGULATION FACTORS; FAMILY HEALTH; FEMALE; GLYCOPROTEINS; HETEROZYGOTE; HUMANS; HYDROPHOBICITY; MALE; MUTATION, MISSENSE; PEDIGREE; PROTEIN C; PROTEIN C DEFICIENCY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RESTRICTION MAPPING; THROMBOSIS;

EID: 27844434709     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH05-05-0326     Document Type: Article

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