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Volumn 126, Issue 11, 2002, Pages 1337-1348

Laboratory issues in diagnosing abnormalities of protein C, thrombomodulin, and endothelial cell protein C receptor

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C; PROTEIN C RECEPTOR; RECEPTOR; THROMBOMODULIN; UNCLASSIFIED DRUG;

EID: 0036881537     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (65)

References (153)
  • 1
    • 0018672331 scopus 로고
    • Human plasma protein C: Isolation, characterization and activation by human thrombin
    • Kisel W. Human plasma protein C: isolation, characterization and activation by human thrombin. J Clin Invest. 1979;64:761-769.
    • (1979) J Clin Invest , vol.64 , pp. 761-769
    • Kisel, W.1
  • 2
    • 0020072618 scopus 로고
    • Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme
    • Marlar RA, Kleiss AJ, Griffin J. Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme. Blood. 1982;59:1067-1072.
    • (1982) Blood , vol.59 , pp. 1067-1072
    • Marlar, R.A.1    Kleiss, A.J.2    Griffin, J.3
  • 3
    • 0001126659 scopus 로고
    • Activation of purified prothrombin to autoprothrombin I or autoprothrombin II (platelet cofactor II) or autoprothrombin II-A
    • Mammen EF, Thomas WR, Seegers WH. Activation of purified prothrombin to autoprothrombin I or autoprothrombin II (platelet cofactor II) or autoprothrombin II-A. Thromb Diath Haemorrh. 1960;5:218-250.
    • (1960) Thromb Diath Haemorrh , vol.5 , pp. 218-250
    • Mammen, E.F.1    Thomas, W.R.2    Seegers, W.H.3
  • 4
    • 0017283234 scopus 로고
    • A new vitamin K-dependent protein: Purification from bovine plasma and preliminary characterization
    • Stenflo J. A new vitamin K-dependent protein: purification from bovine plasma and preliminary characterization. J Biol Chem. 1976;251:355-363.
    • (1976) J Biol Chem , vol.251 , pp. 355-363
    • Stenflo, J.1
  • 5
    • 0002690104 scopus 로고    scopus 로고
    • Protein C, protein S and thrombomodulin
    • Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Philadelphia, Pa: Lippincott Williams & Wilkins
    • Esmon CT, Protein C, protein S and thrombomodulin. In: Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Philadelphia, Pa: Lippincott Williams & Wilkins; 2001:335-353.
    • (2001) Hemostasis and Thrombosis: Basic Principles and Clinical Practice , pp. 335-353
    • Esmon, C.T.1
  • 6
    • 0022549729 scopus 로고
    • Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states
    • D'Angelo SV, Comp PC, Esmon CT, D'Angelo A. Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states. J Clin Invest. 1986;77:416-425.
    • (1986) J Clin Invest , vol.77 , pp. 416-425
    • D'Angelo, S.V.1    Comp, P.C.2    Esmon, C.T.3    D'Angelo, A.4
  • 7
    • 0001904524 scopus 로고    scopus 로고
    • Blood coagulation factors: Their complementary DNAs, genes, and expression
    • Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Philadelphia, Pa: Lippincott Williams & Wilkins
    • Greenberg DL, Davie EW. Blood coagulation factors: their complementary DNAs, genes, and expression. In: Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Philadelphia, Pa: Lippincott Williams & Wilkins; 2001:21-58.
    • (2001) Hemostasis and Thrombosis: Basic Principles and Clinical Practice , pp. 21-58
    • Greenberg, D.L.1    Davie, E.W.2
  • 8
    • 0020491227 scopus 로고
    • Amino acid sequence of the light chain of bovine protein C
    • Fernlund P, Stenflo J. Amino acid sequence of the light chain of bovine protein C. J Biol Chem. 1982;257:12170-12179.
    • (1982) J Biol Chem , vol.257 , pp. 12170-12179
    • Fernlund, P.1    Stenflo, J.2
  • 9
    • 0020491258 scopus 로고
    • Amino acid sequence of the heavy chain of bovine protein C
    • Stenflo J, Fernlund P. Amino acid sequence of the heavy chain of bovine protein C. J Biol Chem. 1982;247:12180-12190.
    • (1982) J Biol Chem , vol.247 , pp. 12180-12190
    • Stenflo, J.1    Fernlund, P.2
  • 10
    • 0002146847 scopus 로고
    • Native and modified recombinant human protein C: Function, secretion, and posttranslational modifications
    • Bruley DF, Drohan WN, eds. Houston, Tex: Gulf Publishing Co. Advances in Applied Biotechnology Series
    • Grinnell BW, Walls JD, Gerlitz B, et al. Native and modified recombinant human protein C: function, secretion, and posttranslational modifications. In: Bruley DF, Drohan WN, eds. Protein C and Related Anticoagulants. Houston, Tex: Gulf Publishing Co; 1991:29-63. Advances in Applied Biotechnology Series; vol 11.
    • (1991) Protein C and Related Anticoagulants , vol.11 , pp. 29-63
    • Grinnell, B.W.1    Walls, J.D.2    Gerlitz, B.3
  • 11
    • 0021240173 scopus 로고
    • Characterization of a cDNA coding for human protein C
    • Foster D, Davie EW. Characterization of a cDNA coding for human protein C. Proc Natl Acad Sci U S A. 1984;81:4766-4770.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 4766-4770
    • Foster, D.1    Davie, E.W.2
  • 14
    • 0023922605 scopus 로고
    • Assignment of the human protein C gene to chromosome region 2q14:q21 by in situ hybridization
    • Kato A, Miura O, Sumi Y, Aoki N. Assignment of the human protein C gene to chromosome region 2q14:q21 by in situ hybridization. Cytogenet Cell Genet. 1988;47:46-47.
    • (1988) Cytogenet Cell Genet , vol.47 , pp. 46-47
    • Kato, A.1    Miura, O.2    Sumi, Y.3    Aoki, N.4
  • 17
    • 0029043736 scopus 로고
    • Protein C deficiency: A database of mutations, 1995
    • Reitsma PH, Bernardi F, Doig RG, et al, for the Subcommittee on Plasma Coagulation Inhibitors of the Scientific and Standardization Committee of the ISTH. Protein C deficiency: a database of mutations, 1995. Thromb Haemost. 1995;73:876-889.
    • (1995) Thromb Haemost , vol.73 , pp. 876-889
    • Reitsma, P.H.1    Bernardi, F.2    Doig, R.G.3
  • 18
    • 0029993520 scopus 로고    scopus 로고
    • Transcriptional regulation of the gene coding for human protein C
    • Miao Ch, Ho WT, Greenberg DL, Davie EW. Transcriptional regulation of the gene coding for human protein C. J Biol Chem. 1996;271:9587-9594.
    • (1996) J Biol Chem , vol.271 , pp. 9587-9594
    • Miao, Ch.1    Ho, W.T.2    Greenberg, D.L.3    Davie, E.W.4
  • 19
    • 0028940777 scopus 로고    scopus 로고
    • Human protein C and activated protein C
    • Castellini FJ. Human protein C and activated protein C. Trends Cardiovasc Med. 1996;5:55-62.
    • (1996) Trends Cardiovasc Med , vol.5 , pp. 55-62
    • Castellini, F.J.1
  • 20
    • 0027567887 scopus 로고
    • Structure-function relationships of the thrombin-thrombomodulin interaction
    • Sadler JE, Lentz SR, Sheehan JP, Tsiang M, Wu Q. Structure-function relationships of the thrombin-thrombomodulin interaction. Haemostasis. 1993;23: 183-193.
    • (1993) Haemostasis , vol.23 , pp. 183-193
    • Sadler, J.E.1    Lentz, S.R.2    Sheehan, J.P.3    Tsiang, M.4    Wu, Q.5
  • 21
    • 0026351350 scopus 로고
    • The active site of thrombin is altered upon binding to thrombomodulin: Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation
    • Ye J, Esmon NL, Esmon CT, Johnson AE. The active site of thrombin is altered upon binding to thrombomodulin: two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation. J Biol Chem. 1991;266:23016-23021.
    • (1991) J Biol Chem , vol.266 , pp. 23016-23021
    • Ye, J.1    Esmon, N.L.2    Esmon, C.T.3    Johnson, A.E.4
  • 22
    • 0027943163 scopus 로고
    • Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor
    • Fukodome K, Esmon CT. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem. 1994;269: 26486-26491.
    • (1994) J Biol Chem , vol.269 , pp. 26486-26491
    • Fukodome, K.1    Esmon, C.T.2
  • 23
    • 0035869411 scopus 로고    scopus 로고
    • Endothelial cell protein C receptor plays an important role in protein C activation in vivo
    • Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT. Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood. 2001;97:1685-1688.
    • (2001) Blood , vol.97 , pp. 1685-1688
    • Taylor F.B., Jr.1    Peer, G.T.2    Lockhart, M.S.3    Ferrell, G.4    Esmon, C.T.5
  • 24
    • 0032080409 scopus 로고    scopus 로고
    • A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state
    • Weiler-Guettler H, Christie PD, Beeler DL, et al. A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J Clin Invest. 1998;101:1983-1991.
    • (1998) J Clin Invest , vol.101 , pp. 1983-1991
    • Weiler-Guettler, H.1    Christie, P.D.2    Beeler, D.L.3
  • 26
    • 0022475245 scopus 로고
    • Purification of a protein C activator from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix)
    • Klein JD, Walker FJ. Purification of a protein C activator from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix). Biochemistry. 1986;25:4175-4179.
    • (1986) Biochemistry , vol.25 , pp. 4175-4179
    • Klein, J.D.1    Walker, F.J.2
  • 27
    • 0029895009 scopus 로고    scopus 로고
    • TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascade through the thrombin-thrombomodulin complex
    • Bajzar L, Morser J, Nesheim M. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascade through the thrombin-thrombomodulin complex. J Biol Chem. 1996;271:16603-16608.
    • (1996) J Biol Chem , vol.271 , pp. 16603-16608
    • Bajzar, L.1    Morser, J.2    Nesheim, M.3
  • 28
    • 0027972573 scopus 로고
    • Phosphatidylethanolamine incorporation intovesicles selectively enhances factor Va inactivation by activated protein C
    • Smirnov MD, Esmon CT. Phosphatidylethanolamine incorporation intovesicles selectively enhances factor Va inactivation by activated protein C. J Biol Chem. 1994;269:816-819.
    • (1994) J Biol Chem , vol.269 , pp. 816-819
    • Smirnov, M.D.1    Esmon, C.T.2
  • 29
    • 0026687609 scopus 로고
    • Role of individual gamma-carboxyglutamic acid residue of activated human protein C in defining its in vitro anticoagulant activity
    • Zhang L, Jhingan A, Castellino FJ. Role of individual gamma-carboxyglutamic acid residue of activated human protein C in defining its in vitro anticoagulant activity. Blood. 1992;80:942-952.
    • (1992) Blood , vol.80 , pp. 942-952
    • Zhang, L.1    Jhingan, A.2    Castellino, F.J.3
  • 30
    • 0027968913 scopus 로고
    • The binding energy of human coagulation protein C to acidic phospholipid vesicles contains a major contribution from leucine 5 in the gamma-carboxyglutamic acid domain
    • Zhang L, Castellin FJ. The binding energy of human coagulation protein C to acidic phospholipid vesicles contains a major contribution from leucine 5 in the gamma-carboxyglutamic acid domain. J Biol Chem. 1994;269:3590-3595.
    • (1994) J Biol Chem , vol.269 , pp. 3590-3595
    • Zhang, L.1    Castellin, F.J.2
  • 31
    • 0022000553 scopus 로고
    • Protein S is required for bovine platelets to support activated protein C binding and activity
    • Harris KW, Esmon CT. Protein S is required for bovine platelets to support activated protein C binding and activity. J Biol Chem. 1985;260:2007-2010.
    • (1985) J Biol Chem , vol.260 , pp. 2007-2010
    • Harris, K.W.1    Esmon, C.T.2
  • 32
    • 0028110027 scopus 로고
    • The mechanism of inactivation of human factor V and human factor Va by activated protein C
    • Kalafatis M, Rand MD, Mann KG. The mechanism of inactivation of human factor V and human factor Va by activated protein C. J Biol Chem. 1994;269: 31869-31880.
    • (1994) J Biol Chem , vol.269 , pp. 31869-31880
    • Kalafatis, M.1    Rand, M.D.2    Mann, K.G.3
  • 33
    • 0025888388 scopus 로고
    • Activated protein C-catalyzed inactivation of human factor VIII and factor Villa
    • Fay PJ, Smudzin TM, Walker FJ. Activated protein C-catalyzed inactivation of human factor VIII and factor Villa. J Biol Chem. 1991;266:20139-20145.
    • (1991) J Biol Chem , vol.266 , pp. 20139-20145
    • Fay, P.J.1    Smudzin, T.M.2    Walker, F.J.3
  • 34
    • 0033709870 scopus 로고    scopus 로고
    • Three dimensional model of coagulation factor Va bound to activated protein C
    • Pellequer JL, Gale AJ, Getzhoff ED, Griffin JH. Three dimensional model of coagulation factor Va bound to activated protein C. Thromb Haemost. 2000; 84:849-857.
    • (2000) Thromb Haemost , vol.84 , pp. 849-857
    • Pellequer, J.L.1    Gale, A.J.2    Getzhoff, E.D.3    Griffin, J.H.4
  • 35
    • 0030608856 scopus 로고    scopus 로고
    • The effect of Arg306-Ala and Arg506-Gn substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S
    • Egan JO, Kalafatis M, Mann KG. The effect of Arg306-Ala and Arg506-Gn substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S. Protein Sci. 1997;6:2016-2027.
    • (1997) Protein Sci , vol.6 , pp. 2016-2027
    • Egan, J.O.1    Kalafatis, M.2    Mann, K.G.3
  • 36
    • 0030843304 scopus 로고    scopus 로고
    • Activated protein C cleavage of factor Va leads to dissociation of the A2 domaim
    • Mann KG, Hockin MF, Begin KJ, Kalafatis M. Activated protein C cleavage of factor Va leads to dissociation of the A2 domaim. J Biol Chem. 1997;272: 20678-20683.
    • (1997) J Biol Chem , vol.272 , pp. 20678-20683
    • Mann, K.G.1    Hockin, M.F.2    Begin, K.J.3    Kalafatis, M.4
  • 37
    • 0031888019 scopus 로고    scopus 로고
    • Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: Implications for the APC resistance test
    • Amano K, Michnick DA, Moussalli M, Kaufman RJ. Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test. Thromb Haemost. 1998;79:557-563.
    • (1998) Thromb Haemost , vol.79 , pp. 557-563
    • Amano, K.1    Michnick, D.A.2    Moussalli, M.3    Kaufman, R.J.4
  • 38
    • 0028290275 scopus 로고
    • Factor protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa
    • Shen L, Dahlback B. Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa. J Biol Chem. 1994;269:18735-18738.
    • (1994) J Biol Chem , vol.269 , pp. 18735-18738
    • Shen, L.1    Dahlback B. V2
  • 39
    • 0027273931 scopus 로고
    • Activation of protein C and its distribution between its inhibitors, protein C inhibitor, α1-antitrypsin and α2-macroglobulin, in patients with disseminated intravascular coagulation
    • Scully MF, Toh CH, Hoogendoorn H, et al. Activation of protein C and its distribution between its inhibitors, protein C inhibitor, α1-antitrypsin and α2-macroglobulin, in patients with disseminated intravascular coagulation. Thromb Haemost. 1993;69:448-453.
    • (1993) Thromb Haemost , vol.69 , pp. 448-453
    • Scully, M.F.1    Toh, C.H.2    Hoogendoorn, H.3
  • 40
    • 0019789514 scopus 로고
    • Deficiency of protein C in congenital thrombotic disease
    • Griffin JH, Evatt B, Zimmerman TS, et al. Deficiency of protein C in congenital thrombotic disease. J Clin Invest. 1981;68:1370-1373.
    • (1981) J Clin Invest , vol.68 , pp. 1370-1373
    • Griffin, J.H.1    Evatt, B.2    Zimmerman, T.S.3
  • 41
    • 0028805704 scopus 로고
    • Two mutations in the promoter region of the human protein C gene: Both cause type I protein C deficiency by disruption of two HNF-3 binding sites
    • Spek CA, Greengard JS, Griffin JH, Bertina RM, Reitsma PH. Two mutations in the promoter region of the human protein C gene: both cause type I protein C deficiency by disruption of two HNF-3 binding sites. J Biol Chem. 1995;270: 24216-24221.
    • (1995) J Biol Chem , vol.270 , pp. 24216-24221
    • Spek, C.A.1    Greengard, J.S.2    Griffin, J.H.3    Bertina, R.M.4    Reitsma, P.H.5
  • 42
    • 0002695076 scopus 로고    scopus 로고
    • Hereditary and acquired thrombophilic syndromes
    • Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Philadelphia, Pa: Lippincott Williams & Wilkins
    • Marder VJ, Matei DE. Hereditary and acquired thrombophilic syndromes. In: Colman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Philadelphia, Pa: Lippincott Williams & Wilkins; 2001:1243-1275.
    • (2001) Hemostasis and Thrombosis: Basic Principles and Clinical Practice , pp. 1243-1275
    • Marder, V.J.1    Matei, D.E.2
  • 43
    • 0020636470 scopus 로고
    • Protein C and the development of skin necrosis during anticoagulant therapy
    • Broekmans AW, Bertina RM, Loelinger EA, et al. Protein C and the development of skin necrosis during anticoagulant therapy. Thromb Haemost. 1983; 49:251.
    • (1983) Thromb Haemost , vol.49 , pp. 251
    • Broekmans, A.W.1    Bertina, R.M.2    Loelinger, E.A.3
  • 44
    • 0024507770 scopus 로고
    • The clinical spectrum of heterozygous protein C deficiency in a large New England kindred
    • Bovill EG, Bauer KA, Dickerman JD, Callas P, West B. The clinical spectrum of heterozygous protein C deficiency in a large New England kindred. Blood. 1989;73:712-717.
    • (1989) Blood , vol.73 , pp. 712-717
    • Bovill, E.G.1    Bauer, K.A.2    Dickerman, J.D.3    Callas, P.4    West, B.5
  • 45
    • 0027465837 scopus 로고
    • Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect
    • Allaart CF, Poort SR, Rosendaal FR, Reitsma PH, Bertina RM, Briet E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet. 1993;341:134-138.
    • (1993) Lancet , vol.341 , pp. 134-138
    • Allaart, C.F.1    Poort, S.R.2    Rosendaal, F.R.3    Reitsma, P.H.4    Bertina, R.M.5    Briet, E.6
  • 46
    • 0021101168 scopus 로고
    • Congenital protein C deficiency and venous thromboembolism: A study of three Dutch families
    • Broekmans AW, Veltkamp JJ, Bertina RM. Congenital protein C deficiency and venous thromboembolism: a study of three Dutch families. N Engl J Med. 1983a;309:340-344.
    • (1983) N Engl J Med , vol.309 , pp. 340-344
    • Broekmans, A.W.1    Veltkamp, J.J.2    Bertina, R.M.3
  • 47
    • 0027272981 scopus 로고
    • The clinical expression of hereditary protein C and protein S deficiency: A relation to clinical thrombotic risk factors and to levels of protein C and protein S?
    • Henkins CMA, Van der Meer J, Hillege JL, Van der Schaaf W, Bom VJJ, Halie MR. The clinical expression of hereditary protein C and protein S deficiency: a relation to clinical thrombotic risk factors and to levels of protein C and protein S? Blood Coagul Fibrinolysis. 1993;4:555-562.
    • (1993) Blood Coagul Fibrinolysis , vol.4 , pp. 555-562
    • Henkins, C.M.A.1    Van der Meer, J.2    Hillege, J.L.3    Van der Schaaf, W.4    Bom, V.J.J.5    Halie, M.R.6
  • 48
    • 0023233223 scopus 로고
    • Absence of thrombosis in subjects with heterozygous protein C deficiency
    • Miletich J, Sherman L, Broze G Jr. Absence of thrombosis in subjects with heterozygous protein C deficiency. N Engl J Med. 1987;317:991-996.
    • (1987) N Engl J Med , vol.317 , pp. 991-996
    • Miletich, J.1    Sherman, L.2    Broze G., Jr.3
  • 51
    • 0023626864 scopus 로고
    • An international collaborative study on the performance of protein C antigen assays
    • Bettina RM. An international collaborative study on the performance of protein C antigen assays. Thromb Haemost. 1987;57:112-117.
    • (1987) Thromb Haemost , vol.57 , pp. 112-117
    • Bettina, R.M.1
  • 52
    • 0013425781 scopus 로고
    • Factor V (FV) Leiden mutation (APC-resistance) increases the risk for venous thromboembolism in patients with a gene defect of the protein C (PC) or protein S (PS) gene [abstract]
    • Pabinger I, Mustafa S, Rintelen C, et al. Factor V (FV) Leiden mutation (APC-resistance) increases the risk for venous thromboembolism in patients with a gene defect of the protein C (PC) or protein S (PS) gene [abstract]. Thromb Haemost. 1995;72:1361.
    • (1995) Thromb Haemost , vol.72 , pp. 1361
    • Pabinger, I.1    Mustafa, S.2    Rintelen, C.3
  • 53
    • 0029743426 scopus 로고    scopus 로고
    • Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis
    • Brenner B, Zivelin A, Lanir N, et al. Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis. Blood. 1996;88:877-880.
    • (1996) Blood , vol.88 , pp. 877-880
    • Brenner, B.1    Zivelin, A.2    Lanir, N.3
  • 54
    • 0028000665 scopus 로고
    • Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families
    • Koeleman BPC, Reitsma PH, Allaart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood. 1994;84:1031-1035.
    • (1994) Blood , vol.84 , pp. 1031-1035
    • Koeleman, B.P.C.1    Reitsma, P.H.2    Allaart, C.F.3    Bertina, R.M.4
  • 55
    • 0000662461 scopus 로고    scopus 로고
    • Incidence of venous thromboembolism in families with inherited thrombophilia
    • Simoni P, Sanson BJ, Prandoni P, et al. Incidence of venous thromboembolism in families with inherited thrombophilia. Thromb Haemost. 1999;81:198-202.
    • (1999) Thromb Haemost , vol.81 , pp. 198-202
    • Simoni, P.1    Sanson, B.J.2    Prandoni, P.3
  • 56
    • 0034061809 scopus 로고    scopus 로고
    • The G20210A prothrombin polymorphism is not associated with increased thromboembolic risk in large protein C deficient kindred
    • Bovill EG, Hasstedt SJ, Callas PW, et al. The G20210A prothrombin polymorphism is not associated with increased thromboembolic risk in large protein C deficient kindred. Thromb Haemost. 2000;83:366-370.
    • (2000) Thromb Haemost , vol.83 , pp. 366-370
    • Bovill, E.G.1    Hasstedt, S.J.2    Callas, P.W.3
  • 58
    • 0025942524 scopus 로고
    • Inherited protein C deficiency and nonhemorrhagic arterial stroke in young adults
    • Camerlingo M, Finazzi G, Casto L, et al. Inherited protein C deficiency and nonhemorrhagic arterial stroke in young adults. Neurology. 1991;41:1371-1373.
    • (1991) Neurology , vol.41 , pp. 1371-1373
    • Camerlingo, M.1    Finazzi, G.2    Casto, L.3
  • 59
    • 0033560660 scopus 로고    scopus 로고
    • Analysis of 45 episodes of arterial occlusive disease in Japanese patients with congenital protein C deficiency
    • Sakata T, Kario K, Katayama Y, et al. Analysis of 45 episodes of arterial occlusive disease in Japanese patients with congenital protein C deficiency. Thromb Res. 1999;94:69-78.
    • (1999) Thromb Res , vol.94 , pp. 69-78
    • Sakata, T.1    Kario, K.2    Katayama, Y.3
  • 60
    • 0000581205 scopus 로고
    • Hereditary protein C deficiency
    • Bertina RM, ed. Edinburgh, Scotland: Churchill Livingstone
    • Broekmans AW, Conard J. Hereditary protein C deficiency. In: Bertina RM, ed. Protein C and Related Proteins. Edinburgh, Scotland: Churchill Livingstone; 1988:160-181.
    • (1988) Protein C and Related Proteins , pp. 160-181
    • Broekmans, A.W.1    Conard, J.2
  • 62
    • 0023090918 scopus 로고
    • Decline of protein C and S and factors II, VII, IX and X during the initiation of warfarin therapy
    • Weiss P, Soff GA, Halkin H, Seligsohn U. Decline of protein C and S and factors II, VII, IX and X during the initiation of warfarin therapy. Thromb Res Suppl. 1987;45:783-790.
    • (1987) Thromb Res Suppl , vol.45 , pp. 783-790
    • Weiss, P.1    Soff, G.A.2    Halkin, H.3    Seligsohn, U.4
  • 63
    • 0030951829 scopus 로고    scopus 로고
    • Laboratory evaluation and clinical characteristics of 2132 consecutive unselected patients with venous thromboembolism: Results of the Spanish Multicentric Study on Thrombophilia (EMET Study)
    • Mateo J, Oliver A, Borrell M, Sala N, Fontcuberta J, and the EMET group. Laboratory evaluation and clinical characteristics of 2132 consecutive unselected patients with venous thromboembolism: results of the Spanish Multicentric Study on Thrombophilia (EMET Study). Thromb Haemost. 1997;77:444-451.
    • (1997) Thromb Haemost , vol.77 , pp. 444-451
    • Mateo, J.1    Oliver, A.2    Borrell, M.3    Sala, N.4    Fontcuberta, J.5
  • 65
    • 0023818347 scopus 로고
    • The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis
    • Gladson CL, Scharrer I, Hach V, Beck KH, Griffin JH. The frequency of type I heterozygous protein S and protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost. 1988;59:18-22.
    • (1988) Thromb Haemost , vol.59 , pp. 18-22
    • Gladson, C.L.1    Scharrer, I.2    Hach, V.3    Beck, K.H.4    Griffin, J.H.5
  • 66
    • 0024441258 scopus 로고
    • Elevated plasminogen activator inhibit (PAI), a cause of thrombophilia? A study in 203 patients with familial or sporadic thrombophilia
    • Engesser L, Brommer EJP, Kluft C, Briet E. Elevated plasminogen activator inhibit (PAI), a cause of thrombophilia? A study in 203 patients with familial or sporadic thrombophilia. Thromb Haemost. 1989;62:673-680.
    • (1989) Thromb Haemost , vol.62 , pp. 673-680
    • Engesser, L.1    Brommer, E.J.P.2    Kluft, C.3    Briet, E.4
  • 67
    • 0003111160 scopus 로고
    • Incidence of defective tPA release in 158 unrelated young patients with venous thrombosis in comparison to PC-, PS-, ATIII-, fibrinogen-, and plasminogen deficiency
    • Scharrer I, Hach-Wunderle V, Heyland H, Kuhn C. Incidence of defective tPA release in 158 unrelated young patients with venous thrombosis in comparison to PC-, PS-, ATIII-, fibrinogen-, and plasminogen deficiency. Thromb Haemost. 1987;58:72.
    • (1987) Thromb Haemost , vol.58 , pp. 72
    • Scharrer, I.1    Hach-Wunderle, V.2    Heyland, H.3    Kuhn, C.4
  • 68
    • 0024563172 scopus 로고
    • The relative frequency of hereditary thrombotic disorders among 107 patients with thrombophilia in Israel
    • Ben Tal O, Zivelin A, Seligsohn U. The relative frequency of hereditary thrombotic disorders among 107 patients with thrombophilia in Israel. Thromb Haemost. 1989;61:50-54.
    • (1989) Thromb Haemost , vol.61 , pp. 50-54
    • Ben Tal, O.1    Zivelin, A.2    Seligsohn, U.3
  • 69
    • 0026749276 scopus 로고
    • Deep vein thrombosis: Prevalence of etiologic factors and results of management in 100 consecutive patients
    • Bick RL, Jakway J, Baker WF. Deep vein thrombosis: prevalence of etiologic factors and results of management in 100 consecutive patients. Semin Thromb Hemost. 1992;18:267-274.
    • (1992) Semin Thromb Hemost , vol.18 , pp. 267-274
    • Bick, R.L.1    Jakway, J.2    Baker, W.F.3
  • 70
    • 0025855781 scopus 로고
    • Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis
    • Taberno MD, Tomia JF, Alberea I, Orfao A, Lopez-Borrasca A, Vicente V. Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis. Am J Hematol. 1991;36:249-254.
    • (1991) Am J Hematol , vol.36 , pp. 249-254
    • Taberno, M.D.1    Tomia, J.F.2    Alberea, I.3    Orfao, A.4    Lopez-Borrasca, A.5    Vicente, V.6
  • 71
    • 0027049831 scopus 로고
    • Congenital thrombophilia among patients with venous thromboembolism
    • Melissari E, Monte G, Lindo VS, et al. Congenital thrombophilia among patients with venous thromboembolism. Blood Coagul Fibrinolysis. 1992;3:749-758.
    • (1992) Blood Coagul Fibrinolysis , vol.3 , pp. 749-758
    • Melissari, E.1    Monte, G.2    Lindo, V.S.3
  • 72
    • 0026695880 scopus 로고
    • Thromboembolic disease: Critical evaluation of laboratory investigation
    • Malm J, Laurell M, Nilsson IM, Dahlback B. Thromboembolic disease: critical evaluation of laboratory investigation. Thromb Haemost. 1992;68:7-13.
    • (1992) Thromb Haemost , vol.68 , pp. 7-13
    • Malm, J.1    Laurell, M.2    Nilsson, I.M.3    Dahlback, B.4
  • 73
    • 0026465569 scopus 로고
    • Hereditary deficiency of antithrombin III, protein C and protein S: Prevalence in patients with a history of venous thrombosis and criteria for rational patient screening
    • Pabinger I, Brucker S, Kyrle PA, et al. Hereditary deficiency of antithrombin III, protein C and protein S: prevalence in patients with a history of venous thrombosis and criteria for rational patient screening. Blood Coagul Fibrinolysis. 1992; 3:547-553.
    • (1992) Blood Coagul Fibrinolysis , vol.3 , pp. 547-553
    • Pabinger, I.1    Brucker, S.2    Kyrle, P.A.3
  • 74
    • 0035082014 scopus 로고    scopus 로고
    • Frequency of natural coagulation inhibitor (antithrombin III, protein C and protein S) deficiencies in Japanese patients with spontaneous deep vein thrombosis
    • Suehisa E, Nomura T, Kawasaki T, Kanakura Y. Frequency of natural coagulation inhibitor (antithrombin III, protein C and protein S) deficiencies in Japanese patients with spontaneous deep vein thrombosis. Blood Coagul Fibrinolysis. 2001;12:95-99.
    • (2001) Blood Coagul Fibrinolysis , vol.12 , pp. 95-99
    • Suehisa, E.1    Nomura, T.2    Kawasaki, T.3    Kanakura, Y.4
  • 75
    • 0025241268 scopus 로고
    • Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis
    • Heijboer H, Brandjes DPM, Buller HR, Sturk A, ten Cate LW. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med. 1990;323:1512-1516.
    • (1990) N Engl J Med , vol.323 , pp. 1512-1516
    • Heijboer, H.1    Brandjes, D.P.M.2    Buller, H.R.3    Sturk, A.4    Ten Cate, L.W.5
  • 76
    • 0029033740 scopus 로고
    • Protein C deficiency in a controlled series of unselected outpatients: An infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study)
    • Koster T, Rosendaal FR, Briet E, et al. Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study). Blood. 1995;85:2756-2761.
    • (1995) Blood , vol.85 , pp. 2756-2761
    • Koster, T.1    Rosendaal, F.R.2    Briet, E.3
  • 77
    • 0028851046 scopus 로고
    • Prevalence of protein C deficiency in the healthy population
    • Tait RC, Walker ID, Reitsma PH, et al. Prevalence of protein C deficiency in the healthy population. Thromb Haemost. 1995;73:87-93.
    • (1995) Thromb Haemost , vol.73 , pp. 87-93
    • Tait, R.C.1    Walker, I.D.2    Reitsma, P.H.3
  • 78
    • 0028272987 scopus 로고
    • The risk of thromboembolism in asymptomatic patients with protein C and protein S deficiency: A prospective cohort study
    • Pabinger I, Kyrle PA, Heistinger M, et al. The risk of thromboembolism in asymptomatic patients with protein C and protein S deficiency: a prospective cohort study. Thromb Haemost. 1994;71:441-445.
    • (1994) Thromb Haemost , vol.71 , pp. 441-445
    • Pabinger, I.1    Kyrle, P.A.2    Heistinger, M.3
  • 79
    • 0024603102 scopus 로고
    • Diagnosis and treatment of homozygous protein C deficiency: Report of the Working Party on Homozygous Protein C Deficiency of the Subcommittee on Protein C and Protein S
    • International Committee on Thrombosis and Haemostasis
    • Marlar RA, Montgomery RR, Broekmans AW, and the Working Party. Diagnosis and treatment of homozygous protein C deficiency: report of the Working Party on Homozygous Protein C Deficiency of the Subcommittee on Protein C and Protein S, International Committee on Thrombosis and Haemostasis. J Pediatr. 1989;114:528-534.
    • (1989) J Pediatr , vol.114 , pp. 528-534
    • Marlar, R.A.1    Montgomery, R.R.2    Broekmans, A.W.3
  • 81
    • 0021124825 scopus 로고
    • Severe inherited "homozygous" protein C deficiency in a newborn infant
    • Estelles A, Garcia-Plaza I, Dasi A, et al. Severe inherited "homozygous" protein C deficiency in a newborn infant. Thromb Haemost. 1984;52:53-56.
    • (1984) Thromb Haemost , vol.52 , pp. 53-56
    • Estelles, A.1    Garcia-Plaza, I.2    Dasi, A.3
  • 82
    • 0021930913 scopus 로고
    • Neonatal purpura fulminans: A genetic disorder related to the absence of protein C in blood
    • Marciniak E, Wilson HD, Marlar RA. Neonatal purpura fulminans: a genetic disorder related to the absence of protein C in blood. Blood. 1985;65:15-20.
    • (1985) Blood , vol.65 , pp. 15-20
    • Marciniak, E.1    Wilson, H.D.2    Marlar, R.A.3
  • 83
    • 0021343348 scopus 로고
    • Homozygous protein C deficiency manifested by massive thrombosis in the newborn
    • Seligsohn U, Berger A, Abend M, et al. Homozygous protein C deficiency manifested by massive thrombosis in the newborn. N Engl J Med. 1984;310:559-562.
    • (1984) N Engl J Med , vol.310 , pp. 559-562
    • Seligsohn, U.1    Berger, A.2    Abend, M.3
  • 84
    • 0021086761 scopus 로고
    • Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant
    • Branson HE, Marble R, Katz J, Griffin JH. Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant. Lancet. 1983;2:1165-1168.
    • (1983) Lancet , vol.2 , pp. 1165-1168
    • Branson, H.E.1    Marble, R.2    Katz, J.3    Griffin, J.H.4
  • 85
    • 0022360202 scopus 로고
    • Protein C in thromboembolic disease
    • Marlar RA. Protein C in thromboembolic disease. Semin Thromb Hemost. 1985;11:387-393.
    • (1985) Semin Thromb Hemost , vol.11 , pp. 387-393
    • Marlar, R.A.1
  • 86
    • 0025285282 scopus 로고
    • Diagnosis of protein C deficiency in patients on oral anticoagulant treatment: Comparison of three different functional protein C assays
    • Pabinger I, Kyrle PA, Speiser W, Stoffels U, Jung M, Lechner K. Diagnosis of protein C deficiency in patients on oral anticoagulant treatment: comparison of three different functional protein C assays. Thromb Haemost. 1990;63:407-412.
    • (1990) Thromb Haemost , vol.63 , pp. 407-412
    • Pabinger, I.1    Kyrle, P.A.2    Speiser, W.3    Stoffels, U.4    Jung, M.5    Lechner, K.6
  • 87
  • 88
    • 0021320040 scopus 로고
    • Liver dysfunction rather than intravascular coagulation as the main cause of low protein C and antithrombin III in acute leukemia
    • Rodeghiero F, Mannucci PM, Vigano S, et al. Liver dysfunction rather than intravascular coagulation as the main cause of low protein C and antithrombin III in acute leukemia. Blood. 1984;63:965-969.
    • (1984) Blood , vol.63 , pp. 965-969
    • Rodeghiero, F.1    Mannucci, P.M.2    Vigano, S.3
  • 89
    • 0021863658 scopus 로고
    • Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation
    • Marlar RA, Endres-Brooks J, Miller C. Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation. Blood. 1985b;66:59-63.
    • (1985) Blood , vol.66 , pp. 59-63
    • Marlar, R.A.1    Endres-Brooks, J.2    Miller, C.3
  • 90
    • 0019977178 scopus 로고
    • Deficiencies of protein C, an inhibitor of blood coagulation
    • Mannucci PM, Vigano S. Deficiencies of protein C, an inhibitor of blood coagulation. Lancet. 1982;2:463-467.
    • (1982) Lancet , vol.2 , pp. 463-467
    • Mannucci, P.M.1    Vigano, S.2
  • 91
    • 0022617457 scopus 로고
    • Decrease and rapid recovery of protein C after plasma exchange
    • Mannucci PM, D'Angelo A, Vigano S, et al. Decrease and rapid recovery of protein C after plasma exchange. Transfusion. 1986;26:156-158.
    • (1986) Transfusion , vol.26 , pp. 156-158
    • Mannucci, P.M.1    D'Angelo, A.2    Vigano, S.3
  • 92
    • 0024583612 scopus 로고
    • Acquired protein C deficiency in patients with breast cancer receiving cyclophosphamide, methotrexate, and 5-fluorouracil
    • Feffer SE, Carmosino LS, Fox RL. Acquired protein C deficiency in patients with breast cancer receiving cyclophosphamide, methotrexate, and 5-fluorouracil. Cancer. 1989;63:1303-1307.
    • (1989) Cancer , vol.63 , pp. 1303-1307
    • Feffer, S.E.1    Carmosino, L.S.2    Fox, R.L.3
  • 93
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699-709.
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 94
    • 0022111559 scopus 로고
    • Plasma concentration of the natural anticoagulants protein C and protein S in patients with proteinurea
    • Cosio FG, Harker C, Batard MA, et al. Plasma concentration of the natural anticoagulants protein C and protein S in patients with proteinurea. J Lab Clin Med. 1985;106:218-222.
    • (1985) J Lab Clin Med , vol.106 , pp. 218-222
    • Cosio, F.G.1    Harker, C.2    Batard, M.A.3
  • 96
    • 0023484707 scopus 로고
    • A fatal thrombotic disorder associated with an acquired inhibitor of protein C
    • Mitchell CA, Rowell JA, Hau L, et al. A fatal thrombotic disorder associated with an acquired inhibitor of protein C. N Engl J Med. 1987;317:1638-1642.
    • (1987) N Engl J Med , vol.317 , pp. 1638-1642
    • Mitchell, C.A.1    Rowell, J.A.2    Hau, L.3
  • 97
    • 0023179188 scopus 로고
    • Development of the human coagulation system in the full term infant
    • Andrew M, Paes B, Milner R, et al. Development of the human coagulation system in the full term infant. Blood. 1987;70:165-172.
    • (1987) Blood , vol.70 , pp. 165-172
    • Andrew, M.1    Paes, B.2    Milner, R.3
  • 99
    • 0021702965 scopus 로고
    • Protein C is not an acute phase reactant and is often high in ischemic heart disease and diabetes
    • Vigano S, Mannucci PM, D'Angelo A, et al. Protein C is not an acute phase reactant and is often high in ischemic heart disease and diabetes. Thromb Haemost. 1984;52:263-266.
    • (1984) Thromb Haemost , vol.52 , pp. 263-266
    • Vigano, S.1    Mannucci, P.M.2    D'Angelo, A.3
  • 100
    • 0021634130 scopus 로고
    • Protein C antigen during pregnancy, delivery and puerperium
    • Mannucci PM, Vigano S, Bottassco B, et al. Protein C antigen during pregnancy, delivery and puerperium. Thromb Haemost. 1984;52:217.
    • (1984) Thromb Haemost , vol.52 , pp. 217
    • Mannucci, P.M.1    Vigano, S.2    Bottassco, B.3
  • 101
    • 0021891705 scopus 로고
    • Effects of oral contraceptives and obesity on protein C antigen
    • Meade TW, Stirling Y, Wilkes H, Mannucci PM. Effects of oral contraceptives and obesity on protein C antigen. Thromb Haemost. 1985;53:198-199.
    • (1985) Thromb Haemost , vol.53 , pp. 198-199
    • Meade, T.W.1    Stirling, Y.2    Wilkes, H.3    Mannucci, P.M.4
  • 102
    • 0030746620 scopus 로고    scopus 로고
    • Thrombomodulin gene variations and thromboembolic disease
    • Ohlin AK, Norlund L, Marlar RA. Thrombomodulin gene variations and thromboembolic disease. Thromb Haemost. 1997;78:396-400.
    • (1997) Thromb Haemost , vol.78 , pp. 396-400
    • Ohlin, A.K.1    Norlund, L.2    Marlar, R.A.3
  • 103
    • 0031056791 scopus 로고    scopus 로고
    • A common thrombomodulin amino acid dimorphism is associated with myocardial infarction
    • Norlund L, Holm J, Zoller B, Ohlin AK. A common thrombomodulin amino acid dimorphism is associated with myocardial infarction. Thromb Haemost. 1997;77:248-251.
    • (1997) Thromb Haemost , vol.77 , pp. 248-251
    • Norlund, L.1    Holm, J.2    Zoller, B.3    Ohlin, A.K.4
  • 105
    • 0032893645 scopus 로고    scopus 로고
    • Mutations in promoter region of thrombomodulin and venous thromboembolic disease
    • Le Flem L, Picard V, Emmerich J, et al. Mutations in promoter region of thrombomodulin and venous thromboembolic disease. Arterioscler Thromb Vasc Biol. 1999;19;1098-1104.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 1098-1104
    • Le Flem, L.1    Picard, V.2    Emmerich, J.3
  • 106
    • 0035572892 scopus 로고    scopus 로고
    • Characterization of a mouse model for thrombomodulin deficiency
    • Weiler H, Lindner V, Kerlin B, et al. Characterization of a mouse model for thrombomodulin deficiency. Arterioscler Thromb Vasc Biol. 2001;21:1531-1537.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1531-1537
    • Weiler, H.1    Lindner, V.2    Kerlin, B.3
  • 107
    • 0027943163 scopus 로고
    • Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor
    • Fukudome K, Esmon DT. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem. 1994a;269: 26486-26491.
    • (1994) J Biol Chem , vol.269 , pp. 26486-26491
    • Fukudome, K.1    Esmon, D.T.2
  • 108
    • 0000020081 scopus 로고    scopus 로고
    • A 23bp insertion in the endothelial protein C receptor (EPCR) gene in patients with myocardial infarction and deep venous thrombosis
    • Merat G, Biguzzi F, Oganesyan N, et al. A 23bp insertion in the endothelial protein C receptor (EPCR) gene in patients with myocardial infarction and deep venous thrombosis [abstract]. Thromb Haemost. 1999;(suppl):507.
    • (1999) Thromb Haemost , Issue.SUPPL. , pp. 507
    • Merat, G.1    Biguzzi, F.2    Oganesyan, N.3
  • 109
    • 0034774749 scopus 로고    scopus 로고
    • A 23bp insertion in the endothelial cell protein C receptor (EPCR) gene impairs EPCR function
    • Biguzzi E, Merati G, Liaw PC, et al. A 23bp insertion in the endothelial cell protein C receptor (EPCR) gene impairs EPCR function. Thromb Haemost. 2001;86:945-948.
    • (2001) Thromb Haemost , vol.86 , pp. 945-948
    • Biguzzi, E.1    Merati, G.2    Liaw, P.C.3
  • 110
    • 0013328822 scopus 로고
    • Assay of protein C by an immuno-enzymatic method (ELISA)
    • Amiral J. Assay of protein C by an immuno-enzymatic method (ELISA). Am Clin Prod Rev. 1984;3:34-35.
    • (1984) Am Clin Prod Rev , vol.3 , pp. 34-35
    • Amiral, J.1
  • 111
    • 0021739739 scopus 로고
    • A new method for the estimation of protein C by ELISA
    • Boyer C, Rothschild C, Wolf M, et al. A new method for the estimation of protein C by ELISA. Thromb Haemost. 1984;36:579-589.
    • (1984) Thromb Haemost , vol.36 , pp. 579-589
    • Boyer, C.1    Rothschild, C.2    Wolf, M.3
  • 113
    • 0021924404 scopus 로고
    • A radioimmunoassay for protein C
    • Ikeda K, Stenflo J. A radioimmunoassay for protein C. Thromb Res. 1985; 39:297-306.
    • (1985) Thromb Res , vol.39 , pp. 297-306
    • Ikeda, K.1    Stenflo, J.2
  • 114
    • 0024374154 scopus 로고
    • Clinical evaluation of protein C: A comparative review of antigenic and functional assays
    • Marlar RA, Adcock DM. Clinical evaluation of protein C: a comparative review of antigenic and functional assays. Hum Pathol. 1989b;20:1040-1047.
    • (1989) Hum Pathol , vol.20 , pp. 1040-1047
    • Marlar, R.A.1    Adcock, D.M.2
  • 115
    • 0023626864 scopus 로고
    • An international collaborative study on the performance of protein C antigen assays
    • Bertina RM. An international collaborative study on the performance of protein C antigen assays. Thromb Haemost. 1987;57:112-117.
    • (1987) Thromb Haemost , vol.57 , pp. 112-117
    • Bertina, R.M.1
  • 116
    • 0023615863 scopus 로고
    • Multicenter comparison of five functional and two immunological assays for protein C
    • Mannucci PM, Boyer C, Tripodi A, et al. Multicenter comparison of five functional and two immunological assays for protein C. Thromb Haemost. 1987; 57:44-48.
    • (1987) Thromb Haemost , vol.57 , pp. 44-48
    • Mannucci, P.M.1    Boyer, C.2    Tripodi, A.3
  • 119
    • 0023875680 scopus 로고
    • Standardization of protein C in plasma: Establishment of an international standard
    • Hubbard AR. Standardization of protein C in plasma: establishment of an international standard. Thromb Haemost. 1988;59:464-467.
    • (1988) Thromb Haemost , vol.59 , pp. 464-467
    • Hubbard, A.R.1
  • 122
    • 0026739904 scopus 로고
    • Hereditary protein C deficiency: Laboratory values in transmitters and guidelines for the diagnostic procedure: Report on a study of the SSC Subcommittee on Protein C and Protein S
    • Pabinger I, Allaart CF, Hermans J, et al. Hereditary protein C deficiency: laboratory values in transmitters and guidelines for the diagnostic procedure: report on a study of the SSC Subcommittee on Protein C and Protein S. Thromb Haemost. 1992b;68:470-474.
    • (1992) Thromb Haemost , vol.68 , pp. 470-474
    • Pabinger, I.1    Allaart, C.F.2    Hermans, J.3
  • 123
    • 0002153516 scopus 로고    scopus 로고
    • The hypercoagulable state
    • Ratnoff OD, Forbes CD, eds. Philadelphia, Pa: Saunders
    • Bauer K. The hypercoagulable state. In: Ratnoff OD, Forbes CD, eds. Disorders of Hemostasis. 3rd ed. Philadelphia, Pa: Saunders; 1996:228-258.
    • (1996) Disorders of Hemostasis. 3rd Ed. , pp. 228-258
    • Bauer, K.1
  • 124
    • 0021021318 scopus 로고
    • A functional assay for protein C in human plasma
    • Francis RB, Patch MJ. A functional assay for protein C in human plasma. Thromb Res. 1983;32:605-613.
    • (1983) Thromb Res , vol.32 , pp. 605-613
    • Francis, R.B.1    Patch, M.J.2
  • 125
    • 0022506820 scopus 로고
    • Fast functional protein C assay using Protac, a novel protein C activator
    • Martinoli JL, Stocker K. Fast functional protein C assay using Protac, a novel protein C activator. Thromb Res. 1986;43:253-264.
    • (1986) Thromb Res , vol.43 , pp. 253-264
    • Martinoli, J.L.1    Stocker, K.2
  • 126
    • 0022893118 scopus 로고
    • Assay of protein C in human plasma: Comparison of amidolytic, coagulation and immunochemical assays
    • Espana F, Estelles A, Aznar J, Gilabert J. Assay of protein C in human plasma: comparison of amidolytic, coagulation and immunochemical assays. Thromb Res. 1986;44:771-782.
    • (1986) Thromb Res , vol.44 , pp. 771-782
    • Espana, F.1    Estelles, A.2    Aznar, J.3    Gilabert, J.4
  • 127
    • 0026569338 scopus 로고
    • A novel functional assay of protein C in human plasma and its comparison with amidolytic and anticoagulant assays
    • Guglielmone HA, Vides MA. A novel functional assay of protein C in human plasma and its comparison with amidolytic and anticoagulant assays. Thromb Haemost. 1992;67:46-49.
    • (1992) Thromb Haemost , vol.67 , pp. 46-49
    • Guglielmone, H.A.1    Vides, M.A.2
  • 128
    • 0023228592 scopus 로고
    • Rapid amidolytic assay of protein C in whole plasma using an activator from the venom of Agkistrodon contortrix
    • Francis RB, Seyfert U. Rapid amidolytic assay of protein C in whole plasma using an activator from the venom of Agkistrodon contortrix. Am J Clin Pathol. 1986;87:619-625.
    • (1986) Am J Clin Pathol , vol.87 , pp. 619-625
    • Francis, R.B.1    Seyfert, U.2
  • 129
    • 0024598266 scopus 로고
    • Functional assays for protein C activity and protein C inhibitor activity in plasma
    • Geiger M, White TM, Griffin JH. Functional assays for protein C activity and protein C inhibitor activity in plasma. Thromb Haemost. 1989;61:86-92.
    • (1989) Thromb Haemost , vol.61 , pp. 86-92
    • Geiger, M.1    White, T.M.2    Griffin, J.H.3
  • 130
    • 0024348331 scopus 로고
    • A simple, automated functional assay for protein C
    • Walker PA, Bauer KA, McDonagh J. A simple, automated functional assay for protein C. Am J Clin Pathol. 1989;92:210-213.
    • (1989) Am J Clin Pathol , vol.92 , pp. 210-213
    • Walker, P.A.1    Bauer, K.A.2    McDonagh, J.3
  • 131
    • 0025200407 scopus 로고
    • Quantitative and functional assays compared for determination of zymogen and activated human protein C
    • Richards SM, Olson T, Keyes LD. Quantitative and functional assays compared for determination of zymogen and activated human protein C. Clin Chem. 1990;36:1892-1896.
    • (1990) Clin Chem , vol.36 , pp. 1892-1896
    • Richards, S.M.1    Olson, T.2    Keyes, L.D.3
  • 132
    • 0025279023 scopus 로고
    • Hereditary dysfunctional protein C molecules (Type II): Assay characterization and proposed classification
    • Marlar RA, Adcock DM, Madden RM. Hereditary dysfunctional protein C molecules (Type II): assay characterization and proposed classification. Thromb Haemost. 1990;63:375-379.
    • (1990) Thromb Haemost , vol.63 , pp. 375-379
    • Marlar, R.A.1    Adcock, D.M.2    Madden, R.M.3
  • 133
    • 18844467682 scopus 로고
    • Spuriously low levels of protein C with Protac activation clotting assay
    • De Moerloose P, Reber G, Bouvier C. Spuriously low levels of protein C with Protac activation clotting assay. Thromb Haemost. 1988;59:543.
    • (1988) Thromb Haemost , vol.59 , pp. 543
    • De Moerloose, P.1    Reber, G.2    Bouvier, C.3
  • 134
    • 0022585649 scopus 로고
    • A simplified PTT-based protein C activity assay using thrombin-thrombomodulin complex
    • Francis RB. A simplified PTT-based protein C activity assay using thrombin-thrombomodulin complex. Thromb Res Suppl. 1986;41:337-344.
    • (1986) Thromb Res Suppl , vol.41 , pp. 337-344
    • Francis, R.B.1
  • 135
    • 0022549729 scopus 로고
    • Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states
    • Vigano D'Angelo S, Comp PC, Esmon CT, et al. Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states. J Clin Invest. 1986;77:416-425.
    • (1986) J Clin Invest , vol.77 , pp. 416-425
    • Vigano D'Angelo, S.1    Comp, P.C.2    Esmon, C.T.3
  • 136
    • 0025847637 scopus 로고
    • Lack of agreement of chromogenic and clotting assays for factor X and protein C in warfarinised plasma
    • Han P, Fung KP, Rahdakrishnan U. Lack of agreement of chromogenic and clotting assays for factor X and protein C in warfarinised plasma. Thromb Haemost. 1991;65:360-363.
    • (1991) Thromb Haemost , vol.65 , pp. 360-363
    • Han, P.1    Fung, K.P.2    Rahdakrishnan, U.3
  • 138
    • 0027446268 scopus 로고
    • Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C
    • Dahlback B, Cadsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A. 1993;90:1004-1008.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 1004-1008
    • Dahlback, B.1    Cadsson, M.2    Svensson, P.J.3
  • 139
    • 0029018856 scopus 로고
    • The PCAT: A simple screening assay for assessing the functionality of the protein C anticoagulant pathway
    • Krauss M, Noah M, Fichenscher K. The PCAT: a simple screening assay for assessing the functionality of the protein C anticoagulant pathway. Thromb Res. 1995;79:217-222.
    • (1995) Thromb Res , vol.79 , pp. 217-222
    • Krauss, M.1    Noah, M.2    Fichenscher, K.3
  • 140
    • 0029990105 scopus 로고    scopus 로고
    • Anticoagulant response to Agkistrodon contortrix venom (ACV) test: A new global test to screen for defects in the anticoagulant protein C pathway
    • Robert A, Eschwege V, Hameg H, Drouet L, Aillaud MF. Anticoagulant response to Agkistrodon contortrix venom (ACV) test: a new global test to screen for defects in the anticoagulant protein C pathway. Thromb Haemost. 1996;75: 562-565.
    • (1996) Thromb Haemost , vol.75 , pp. 562-565
    • Robert, A.1    Eschwege, V.2    Hameg, H.3    Drouet, L.4    Aillaud, M.F.5
  • 141
    • 0030609944 scopus 로고    scopus 로고
    • Proc Global: The first functional screening assay for the complete protein C pathway
    • Dati F, Hafner G, Erbes H, et al. Proc Global: the first functional screening assay for the complete protein C pathway. Clin Chemistry. 1997;43:1719-1723.
    • (1997) Clin Chemistry , vol.43 , pp. 1719-1723
    • Dati, F.1    Hafner, G.2    Erbes, H.3
  • 142
    • 0031656642 scopus 로고    scopus 로고
    • A protein C pathway (PCP) screening test for the detection of APC resistance and protein C or S deficiencies
    • Haas FJLM, van Sterkenburg-Kamp BM, Scheepers HAMM. A protein C pathway (PCP) screening test for the detection of APC resistance and protein C or S deficiencies. Semin Thromb Hemost. 1998;24:355-362.
    • (1998) Semin Thromb Hemost , vol.24 , pp. 355-362
    • Haas, F.J.L.M.1    Van Sterkenburg-Kamp, B.M.2    Scheepers, H.A.M.M.3
  • 143
    • 0032999389 scopus 로고    scopus 로고
    • Evaluation of a new screening assay, protein C pathway (PCP) test, for identification of defects in the protein C pathway
    • Neuwald C, Heinschink A, Muller MM. Evaluation of a new screening assay, protein C pathway (PCP) test, for identification of defects in the protein C pathway. Thromb Haemost. 1999;81:992-994.
    • (1999) Thromb Haemost , vol.81 , pp. 992-994
    • Neuwald, C.1    Heinschink, A.2    Muller, M.M.3
  • 144
    • 0030862638 scopus 로고    scopus 로고
    • Evaluation of a new screening assay Proc Global for identification of defects in the protein C/protein S anticoagulation pathway
    • Ruzicka K, Kapiotis S, Quehenberger P, et al. Evaluation of a new screening assay Proc Global for identification of defects in the protein C/protein S anticoagulation pathway. Thromb Res. 1997;87:501-510.
    • (1997) Thromb Res , vol.87 , pp. 501-510
    • Ruzicka, K.1    Kapiotis, S.2    Quehenberger, P.3
  • 145
    • 0034014597 scopus 로고    scopus 로고
    • Screening for risk factors for thrombosis using a new generation of assays developed to evaluate the functionality of the protein C anticoagulant pathway
    • Toulon P, Perez P. Screening for risk factors for thrombosis using a new generation of assays developed to evaluate the functionality of the protein C anticoagulant pathway. Hematol Oncol Clin North Am. 2000;14:379-389.
    • (2000) Hematol Oncol Clin North Am , vol.14 , pp. 379-389
    • Toulon, P.1    Perez, P.2
  • 146
    • 0033866504 scopus 로고    scopus 로고
    • Screening for abnormalities of the protein C anticoagulant pathway using the Proc Global assay: Results of a European multicenter evaluation
    • Toulon P, Halbmayer WM, Hafner G, et al. Screening for abnormalities of the protein C anticoagulant pathway using the Proc Global assay: results of a European multicenter evaluation. Blood Coagul Fibrinolysis. 2000;11:447-453.
    • (2000) Blood Coagul Fibrinolysis , vol.11 , pp. 447-453
    • Toulon, P.1    Halbmayer, W.M.2    Hafner, G.3
  • 147
    • 0032213122 scopus 로고    scopus 로고
    • A modified functional global test to measure protein C, protein S activities and the activated protein C-resistance phenotype
    • Gemmati D, Serino ML, Scapoli GL. A modified functional global test to measure protein C, protein S activities and the activated protein C-resistance phenotype. Thromb Res. 1998;92:141-148.
    • (1998) Thromb Res , vol.92 , pp. 141-148
    • Gemmati, D.1    Serino, M.L.2    Scapoli, G.L.3
  • 148
    • 0031710556 scopus 로고    scopus 로고
    • The anticoagulant potential of the protein C system in hereditary and acquired thrombophilia: Pathomechanisms and new tools for assessing its clinical relevance
    • Krauss M. The anticoagulant potential of the protein C system in hereditary and acquired thrombophilia: pathomechanisms and new tools for assessing its clinical relevance. Semin Thromb Hemost. 1998;24:337-354.
    • (1998) Semin Thromb Hemost , vol.24 , pp. 337-354
    • Krauss, M.1
  • 150
    • 0036881556 scopus 로고    scopus 로고
    • Laboratory evaluation of hypercoagulability with venous or arterial thrombosis: Venous thromboembolism, myocardial infarction, stroke, and other conditions
    • Van Cott EM, Laposata M, Prins MH. Laboratory evaluation of hypercoagulability with venous or arterial thrombosis: venous thromboembolism, myocardial infarction, stroke, and other conditions. Arch Pathol Lab Med. 2001;126:1281-1295.
    • (2001) Arch Pathol Lab Med , vol.126 , pp. 1281-1295
    • Van Cott, E.M.1    Laposata, M.2    Prins, M.H.3
  • 151
    • 0033933677 scopus 로고    scopus 로고
    • A randomized cross-over study on the effects of levonorgestrel and desogestrel-containing oral contraceptives on the anticoagulant pathways
    • Tans G, Cuivers J, Middledorp S, et al. A randomized cross-over study on the effects of levonorgestrel and desogestrel-containing oral contraceptives on the anticoagulant pathways. Thromb Haemost. 2000;84:15-21.
    • (2000) Thromb Haemost , vol.84 , pp. 15-21
    • Tans, G.1    Cuivers, J.2    Middledorp, S.3
  • 152
    • 0031984036 scopus 로고    scopus 로고
    • Third generation oral contraceptives and heritable thrombophilia as risk factors of non-fatal venous thromboembolism
    • Anderson BS, Olsen J, Nielsen GL, et al. Third generation oral contraceptives and heritable thrombophilia as risk factors of non-fatal venous thromboembolism. Thromb Haemost. 1998;79:28-31.
    • (1998) Thromb Haemost , vol.79 , pp. 28-31
    • Anderson, B.S.1    Olsen, J.2    Nielsen, G.L.3
  • 153
    • 0021359471 scopus 로고
    • The use of functional and immunologic assay for plasma protein C in the study of the heterogeneity of congenital protein C deficiency
    • Bertina RM, Broekmans AW, Van es Krommenhoek C, Van Wijn Arden A. The use of functional and immunologic assay for plasma protein C in the study of the heterogeneity of congenital protein C deficiency. Thromb Haemost. 1984; 51:1-5.
    • (1984) Thromb Haemost , vol.51 , pp. 1-5
    • Bertina, R.M.1    Broekmans, A.W.2    Van es Krommenhoek, C.3    Van Wijn Arden, A.4


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