Crystal structures of the wild-type, P1A mutant, and inactivated malonate semialdehyde decarboxylase: A structural basis for the decarboxylase and hydratase activities

Biochemistry

Volumn 44, Issue 45, 2005, Pages 14818-14827

  Almrud, Jeffrey J ^a   Poelarends, Gerrit J ^a,b   Johnson Jr , William H ^a   Serrano, Hector ^a   Hackert, Marvin L ^a   Whitman, Christian P ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; CATALYSIS; CRYSTAL STRUCTURE; UNSATURATED COMPOUNDS;

HYDRATASE ACTIVITY; MALONATE SEMIALDEHYDE DECARBOXYLASE (MSAD); TAUTOMERASE;

ENZYME KINETICS;

1,3 DICHLOROPROPENE; 2 OXO 3 PENTYNOATE; 3 CHLOROACRYLIC ACID DEHALOGENASE; 3 CHLOROPROPIOLATE; 3 OXOPROPANOATE; ACETALDEHYDE; ACETOPYRUVATE; ACRYLIC ACID DERIVATIVE; ALKYNE DERIVATIVE; ARGININE; ASPARTIC ACID; BACTERIAL ENZYME; CARBOXYLIC ACID; CARBOXYLYASE; ENZYME; ENZYME INHIBITOR; HYDROLYASE; MALONATE SEMIALDEHYDE; MALONATE SEMIALDEHYDE DEHYDROGENASE; MALONIC ACID DERIVATIVE; MUTANT PROTEIN; OXIDOREDUCTASE; PROLINE; PROPIONIC ACID DERIVATIVE; PROPYLENE; PYRUVIC ACID DERIVATIVE; TAUTOMERASE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME STRUCTURE; GEOMETRY; MICHAEL ADDITION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN FAMILY; PSEUDOMONAS; PSEUDOMONAS PAVONACEAE 170; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ARGININE; BINDING SITES; CARBOXY-LYASES; CRYSTALLOGRAPHY, X-RAY; HYDRO-LYASES; ISOMERASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROLINE; PSEUDOMONAS;

BACTERIA (MICROORGANISMS); PSEUDOMONAS; PSEUDOMONAS PAVONACEAE;

EID: 27744608878     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051383m     Document Type: Article

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