Biochemistry: A thiolate-ligated nonheme oxoiron(IV) complex relevant to cytochrome P450

Science

Volumn 310, Issue 5750, 2005, Pages 1000-1002

  Bukowski, Michael R ^a,e   Koehntop, Kevin D ^a,f   Stubna, Audria ^b   Bominaar, Emile L ^b   Halfen, Jason A ^c   Münck, Eckard ^b   Nam, Wonwoo ^d   Que Jr , Lawrence ^a  

^a University of Minnesota   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN EAU CLAIRE   (United States)

^d Ewha Womans University   (South Korea)

^e PENNSYLVANIA STATE UNIVERSITY   (United States)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; CHARACTERIZATION; IRON COMPOUNDS; OXIDATION; OXYGEN;

CYTOCHROME; REACTIVITY; THIOLATE;

BIOCHEMISTRY;

CYTOCHROME P450; HYDROGEN; IRON COMPLEX; ISOPENICILLIN N SYNTHETASE; LIGAND; NITRIC OXIDE SYNTHASE; OXIDIZING AGENT; OXYGEN; REDUCING AGENT; THIOL DERIVATIVE; (FEIV(O)(TMCS))+; IRON; SULFUR;

BIOCHEMISTRY;

ABSORPTION SPECTROSCOPY; ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL INTERACTION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; DENSITY FUNCTIONAL THEORY; ELECTRON TRANSPORT; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; GEOMETRY; HYDROGEN BOND; INFRARED SPECTROSCOPY; MAGNETIC FIELD; MOLECULAR STABILITY; MOSSBAUER SPECTROSCOPY; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS; TEMPERATURE DEPENDENCE; CHEMISTRY; METABOLISM; OXIDATION REDUCTION REACTION; PHYSICAL CHEMISTRY; SPECTROSCOPY; TEMPERATURE; X RAY;

CATALYSIS; CHEMISTRY, PHYSICAL; CYTOCHROME P-450 ENZYME SYSTEM; HYDROGEN; IRON; LIGANDS; MOLECULAR STRUCTURE; OXIDANTS; OXIDATION-REDUCTION; OXYGEN; SPECTROSCOPY, MOSSBAUER; SPECTRUM ANALYSIS; SULFHYDRYL COMPOUNDS; SULFUR; TEMPERATURE; X-RAYS;

EID: 27744591940     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1119092     Document Type: Article

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27. This work was supported by NIH grants CM-33162 to L.Q., EB-001475 to E.M., and a predoctoral traineeship to K.D.K. under training grant T32 CM-08700; by NSF grant CHE-0243951 to J.A.H. and graduate research fellowship to A.S.; and by the Ministry of Science and Technology of Korea through the Creative Research Initiative Program to W.N. J.A.H. acknowledges the support of NSF/Research Site for Educators in Chemistry grant CHE-0113894 during his sabbatical at the University of Minnesota. X-ray absorption spectroscopy data were collected on beam line 7-3 at the Stanford Synchrotron Radiation Laboratory, which is supported by the U.S. Department of Energy and the NIH Research Resource program.