Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes in cell proliferation and detachment

Journal of Steroid Biochemistry and Molecular Biology

Volumn 97, Issue 3, 2005, Pages 278-288

  Pawlak, K J ^a   Zhang, G ^a   Wiebe, J P ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

3 Dihydroprogesterone; 3 HP; 5 Dihydroprogesterone; 5 P; Breast cancer; Cell adhesion; Cell proliferation; MCF 10A cells; MCF 7 cells; Membrane receptor; Progesterone metabolites; Receptor regulation

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; CYCLOHEXIMIDE; DACTINOMYCIN; ESTRADIOL; MEMBRANE RECEPTOR; PROGESTERONE; 3 HYDROXYPREGN 4 EN 20 ONE; 3-HYDROXYPREGN-4-EN-20-ONE; 5ALPHA PREGNANE 3,20 DIONE; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; ESTRADIOL RECEPTOR; PROGESTERONE RECEPTOR;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL COUNT; CELL MEMBRANE; CELL PROLIFERATION; CELL TYPE; DOSE RESPONSE; DOWN REGULATION; HORMONE ACTION; HORMONE BINDING; HUMAN; HUMAN CELL; METASTASIS; RECEPTOR AFFINITY; TRANSCRIPTION INITIATION; TRANSLATION INITIATION; UPREGULATION; BREAST TUMOR; CELL ADHESION; CELL FRACTIONATION; CHEMISTRY; DRUG EFFECT; FEMALE; METABOLISM; TUMOR CELL LINE;

MINK CELL FOCUS-FORMING VIRUS;

20-ALPHA-DIHYDROPROGESTERONE; 5-ALPHA-DIHYDROPROGESTERONE; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL ADHESION; CELL FRACTIONATION; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CYCLOHEXIMIDE; DACTINOMYCIN; DOWN-REGULATION; ESTRADIOL; FEMALE; HUMANS; PROGESTERONE; RECEPTORS, ESTRADIOL; RECEPTORS, PROGESTERONE; UP-REGULATION;

EID: 27744558272     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.05.014     Document Type: Article

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