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Volumn 9, Issue 2, 2005, Pages 89-94

Use of duplex PCR-CTPP methods for CYP2E1 RsaI/IL-2 T-330G and IL-1B C-31T/TNF-A T-1031C polymorphisms

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2E1; DNA; INTERLEUKIN 1BETA; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN 1; PRIMER DNA;

EID: 27744557551     PISSN: 10848592     EISSN: 10848592     Source Type: Journal    
DOI: 10.2165/00066982-200509020-00005     Document Type: Article
Times cited : (11)

References (40)
  • 1
    • 0033779062 scopus 로고    scopus 로고
    • Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping
    • Sep
    • Hamajima N, Saito T, Matsuo K, et al. Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping. Jpn J Cancer Res 2000 Sep; 91 (9): 865-8
    • (2000) Jpn J Cancer Res , vol.91 , Issue.9 , pp. 865-868
    • Hamajima, N.1    Saito, T.2    Matsuo, K.3
  • 2
    • 0035559450 scopus 로고    scopus 로고
    • PCR-CTPP: A new genotyping technique in the era of genetic epidemiology
    • May
    • Hamajima N. PCR-CTPP: a new genotyping technique in the era of genetic epidemiology. Expert Rev Mol Diagn 2001 May; 1 (1): 119-23
    • (2001) Expert Rev Mol Diagn , vol.1 , Issue.1 , pp. 119-123
    • Hamajima, N.1
  • 3
    • 0036107148 scopus 로고    scopus 로고
    • Competitive amplification and unspecific amplification in polymerase chain reaction with confronting two-pair primers (PCR-CTPP)
    • May
    • Hamajima N, Saito T, Matsuo K, et al. Competitive amplification and unspecific amplification in polymerase chain reaction with confronting two-pair primers (PCR-CTPP). J Mol Diagn 2002 May; 4 (2): 103-7
    • (2002) J Mol Diagn , vol.4 , Issue.2 , pp. 103-107
    • Hamajima, N.1    Saito, T.2    Matsuo, K.3
  • 4
    • 0036559414 scopus 로고    scopus 로고
    • Genotype frequencies for 50 polymorphisms for 241 Japanese non-cancer patients
    • May
    • Hamajima N, Saito T, Matsuo K, et al. Genotype frequencies for 50 polymorphisms for 241 Japanese non-cancer patients. J Epidemiol 2002 May; 12 (3): 229-36
    • (2002) J Epidemiol , vol.12 , Issue.3 , pp. 229-236
    • Hamajima, N.1    Saito, T.2    Matsuo, K.3
  • 5
    • 30344470247 scopus 로고    scopus 로고
    • A new genotyping method, PCR-CTPP
    • Sep
    • Atsuta Y, Hamajima N. A new genotyping method, PCR-CTPP [in Japanese]. Rinsho Byori 2003 Sep; 51 (9): 886-91
    • (2003) Rinsho Byori , vol.51 , Issue.9 , pp. 886-891
    • Atsuta, Y.1    Hamajima, N.2
  • 6
    • 10744231643 scopus 로고    scopus 로고
    • Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase B subunit (ADH2) and aldehyde dehydrogenase (ALDH2)
    • Sep-Oct
    • Tamakoshi A, Hamajima N, Kawase H, et al. Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase B subunit (ADH2) and aldehyde dehydrogenase (ALDH2). Alcohol 2003 Sep-Oct; 38 (5): 407-10
    • (2003) Alcohol , vol.38 , Issue.5 , pp. 407-410
    • Tamakoshi, A.1    Hamajima, N.2    Kawase, H.3
  • 7
    • 0038728807 scopus 로고    scopus 로고
    • Triplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for NQO1 C609T, GSTM1, and GSTT1 polymorphisms: The most convenient genotyping method
    • Jan-Mar
    • Kawase H, Hamajima N, Tamakoshi A, et al. Triplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for NQO1 C609T, GSTM1, and GSTT1 polymorphisms: the most convenient genotyping method. Asian Pac J Cancer Prev 2003 Jan-Mar; 4 (1): 67-70
    • (2003) Asian Pac J Cancer Prev , vol.4 , Issue.1 , pp. 67-70
    • Kawase, H.1    Hamajima, N.2    Tamakoshi, A.3
  • 8
    • 0026062622 scopus 로고
    • Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene
    • Sep
    • Hayashi S, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem 1991 Sep; 110 (3): 559-65
    • (1991) J Biochem , vol.110 , Issue.3 , pp. 559-565
    • Hayashi, S.1    Watanabe, J.2    Kawajiri, K.3
  • 9
    • 0026486899 scopus 로고
    • Cytochrome P450IIEI genetic polymorphisms, racial variation, and lung cancer risk
    • Dec
    • Kato S, Shields PG, Caporaso NE, et al. Cytochrome P450IIEI genetic polymorphisms, racial variation, and lung cancer risk. Cancer Res 1992 Dec; 52 (23): 6712-5
    • (1992) Cancer Res , vol.52 , Issue.23 , pp. 6712-6715
    • Kato, S.1    Shields, P.G.2    Caporaso, N.E.3
  • 10
    • 0031425983 scopus 로고    scopus 로고
    • Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer
    • May
    • Wu X, Shi H, Jiang H, et al. Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer. Carci-nogenesis 1997 May; 18 (5): 967-73
    • (1997) Carcinogenesis , vol.18 , Issue.5 , pp. 967-973
    • Wu, X.1    Shi, H.2    Jiang, H.3
  • 11
    • 0032211358 scopus 로고    scopus 로고
    • Association of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens
    • Nov
    • Le Marchand L, SIvaraman L, Pierce L, et al. Association of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. Cancer Res 1998 Nov; 58 (21): 4858-63
    • (1998) Cancer Res , vol.58 , Issue.21 , pp. 4858-4863
    • Le Marchand, L.1    SIvaraman, L.2    Pierce, L.3
  • 12
    • 0033860266 scopus 로고    scopus 로고
    • Role of alcohol dehydrogenase 3 and cytochrome p-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract
    • Sep
    • Bouchardy C, Hirvonen A, Coutelle C, et al. Role of alcohol dehydrogenase 3 and cytochrome p-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int J Cancer 2000 Sep; 87 (5): 734-40
    • (2000) Int J Cancer , vol.87 , Issue.5 , pp. 734-740
    • Bouchardy, C.1    Hirvonen, A.2    Coutelle, C.3
  • 13
    • 0031788098 scopus 로고    scopus 로고
    • Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferase T1, P1, and M1 and cytochrome P450 2E1
    • Nov
    • Lin DX, Tang YM, Peng Q, et al. Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferase T1, P1, and M1 and cytochrome P450 2E1. Cancer Epidemiol Biomarkers Prev 1998 Nov; 7 (11): 1013-8
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , Issue.11 , pp. 1013-1018
    • Lin, D.X.1    Tang, Y.M.2    Peng, Q.3
  • 14
    • 0034046238 scopus 로고    scopus 로고
    • Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China
    • Jun
    • Tan W, Song N, Wang GQ, et al. Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China. Cancer Epidemiol Biomarkers Prev 2000 Jun; 9 (10): 551-6
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , Issue.10 , pp. 551-556
    • Tan, W.1    Song, N.2    Wang, G.Q.3
  • 15
    • 0029080804 scopus 로고
    • Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellu-lar carcinoma
    • Yu MW, Gladek-Yarborough A, Chiamprasert S, et al. Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellu-lar carcinoma. Gastroenterology 1995; 109: 1266-73
    • (1995) Gastroenterology , vol.109 , pp. 1266-1273
    • Yu, M.W.1    Gladek-Yarborough, A.2    Chiamprasert, S.3
  • 16
    • 12444302843 scopus 로고    scopus 로고
    • CYP2E1 and NQO1 genotypes, smoking and bladder cancer
    • Jun
    • Choi JY, Lee KM, Cho SH, et al. CYP2E1 and NQO1 genotypes, smoking and bladder cancer. Pharmacogenetics 2003 Jun; 13 (6): 349-55
    • (2003) Pharmacogenetics , vol.13 , Issue.6 , pp. 349-355
    • Choi, J.Y.1    Lee, K.M.2    Cho, S.H.3
  • 17
    • 0030728722 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1: Environmental factors and risk of oral cancer
    • Nov
    • Hung HC, Chuang J, Chien YC, et al. Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1: environmental factors and risk of oral cancer. Cancer Epidemiol Biomarkers Prev 1997 Nov; 6 (11): 901-5
    • (1997) Cancer Epidemiol Biomarkers Prev , vol.6 , Issue.11 , pp. 901-905
    • Hung, H.C.1    Chuang, J.2    Chien, Y.C.3
  • 18
    • 0030749790 scopus 로고    scopus 로고
    • CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan
    • Aug
    • Hildesheim A, Anderson LM, Chen CJ, et al. CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst 1997 Aug; 89 (16): 1207-12
    • (1997) J Natl Cancer Inst , vol.89 , Issue.16 , pp. 1207-1212
    • Hildesheim, A.1    Anderson, L.M.2    Chen, C.J.3
  • 19
    • 0029793680 scopus 로고    scopus 로고
    • RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma
    • Aug
    • Ladero JM, Agundez JA, Rodriguez-Lescure A, et al. RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma. Gut 1996 Aug, 3
    • (1996) Gut , pp. 3
    • Ladero, J.M.1    Agundez, J.A.2    Rodriguez-Lescure, A.3
  • 20
    • 15444355381 scopus 로고    scopus 로고
    • Polymorphism in cytochrome P 450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: Studies in upper aerodigestive tract cancers
    • Mattias C, Bockmuhl U, Jahnke V, et al. Polymorphism in cytochrome P 450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. Pharmacogenetics 1998; 8: 91-100
    • (1998) Pharmacogenetics , vol.8 , pp. 91-100
    • Mattias, C.1    Bockmuhl, U.2    Jahnke, V.3
  • 21
    • 0030967278 scopus 로고    scopus 로고
    • CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus
    • Apr
    • Morita S, Yano M, Shiozaki H, et al. CYP1A1, CYP2E1 and GSTM1 polymorph-isms are not associated with susceptibility to squamous-cell carcinoma of the esophagus. Int J Cancer 1997 Apr; 71 (2): 192-5
    • (1997) Int J Cancer , vol.71 , Issue.2 , pp. 192-195
    • Morita, S.1    Yano, M.2    Shiozaki, H.3
  • 22
    • 15544381297 scopus 로고
    • Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease
    • Kato S, Onda M, Matsukura N, et al. Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease. Pharmacogenetics 1995; 5: S141-4
    • (1995) Pharmacogenetics , vol.5
    • Kato, S.1    Onda, M.2    Matsukura, N.3
  • 23
    • 18544408734 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: Case control studies of Japanese Brazilians and non-Japanese Brazilians
    • Jul
    • Nishimoto I, Hanaoka T, Sugimura H, et al. Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: case control studies of Japanese Brazilians and non-Japanese Brazilians. Cancer Epidemiol Biomarkers Prev 2000 Jul; 9 (7): 675-80
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , Issue.7 , pp. 675-680
    • Nishimoto, I.1    Hanaoka, T.2    Sugimura, H.3
  • 24
    • 0036165470 scopus 로고    scopus 로고
    • Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese
    • Jan
    • Gao C, Takezaki T, Wu J, et al. Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese. Cancer Epidemiol Biomarkers Prev 2002 Jan; 11 (1): 29-34
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , Issue.1 , pp. 29-34
    • Gao, C.1    Takezaki, T.2    Wu, J.3
  • 25
    • 0027401426 scopus 로고
    • Genetic polymorphism of cytochrome P4502E1 in a Swedish population: Relationship to incidence of lung cancer
    • Mar
    • Persson I, Johansson I, Bergling H, et al. Genetic polymorphism of cytochrome P4502E1 in a Swedish population: relationship to incidence of lung cancer. FEBS Lett 1993 Mar; 319 (3): 207-11
    • (1993) FEBS Lett , vol.319 , Issue.3 , pp. 207-211
    • Persson, I.1    Johansson, I.2    Bergling, H.3
  • 26
    • 0027302424 scopus 로고
    • The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population
    • Jan
    • Hirvonen A, Husgafvel-Pursiainen K, Anttila S, et al. The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population. Carcinogenesis 1993 Jan; 14 (1): 85-8
    • (1993) Carcinogenesis , vol.14 , Issue.1 , pp. 85-88
    • Hirvonen, A.1    Husgafvel-Pursiainen, K.2    Anttila, S.3
  • 27
    • 0028944689 scopus 로고
    • An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population
    • Mar
    • Watanabe J, Yang J-P, Eguchi H, et al. An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population. Jpn J Cancer Res 1995 Mar; 86 (3): 245-8
    • (1995) Jpn J Cancer Res , vol.86 , Issue.3 , pp. 245-248
    • Watanabe, J.1    Yang, J.-P.2    Eguchi, H.3
  • 28
    • 0029879495 scopus 로고    scopus 로고
    • Lung cancer risk in relation to the CYP2E1 RsaI genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California
    • Apr
    • London SJ, Daly AK, Cooper J, et al. Lung cancer risk in relation to the CYP2E1 RsaI genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California. Pharmacogenetics 1996 Apr; 6 (2): 151-8
    • (1996) Pharmacogenetics , vol.6 , Issue.2 , pp. 151-158
    • London, S.J.1    Daly, A.K.2    Cooper, J.3
  • 29
    • 0029833473 scopus 로고    scopus 로고
    • Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients
    • Sep
    • Anwar WA, Abdel-Rahman SZ, El-Zein RA, et al. Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients. Carcinogenesis 1996 Sep; 17 (9): 1923-9
    • (1996) Carcinogenesis , vol.17 , Issue.9 , pp. 1923-1929
    • Anwar, W.A.1    Abdel-Rahman, S.Z.2    El-Zein, R.A.3
  • 30
    • 0037371329 scopus 로고    scopus 로고
    • Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells
    • Mar
    • Hakkola J, Hu Y. Ingelman-Sundberg M. Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells. J Pharmacol Exp Ther 2003 Mar; 304 (3): 1048-54
    • (2003) J Pharmacol Exp Ther , vol.304 , Issue.3 , pp. 1048-1054
    • Hakkola, J.1    Hu, Y.2    Ingelman-Sundberg, M.3
  • 31
    • 0033561594 scopus 로고    scopus 로고
    • Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy
    • Apr
    • Elkahwaji J, Robin MA, Berson A, et al. Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. Biochem Pharmacol 1999 Apr; 57 (8): 951-4
    • (1999) Biochem Pharmacol , vol.57 , Issue.8 , pp. 951-954
    • Elkahwaji, J.1    Robin, M.A.2    Berson, A.3
  • 32
    • 0029808476 scopus 로고    scopus 로고
    • Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury
    • Nov
    • Tindberg N, Baldwin HA, Cross AJ, et al. Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury. Mol Pharmacol 1996 Nov; 50 (5): 1065-72
    • (1996) Mol Pharmacol , vol.50 , Issue.5 , pp. 1065-1072
    • Tindberg, N.1    Baldwin, H.A.2    Cross, A.J.3
  • 33
    • 0028851831 scopus 로고
    • The interleukin-2 receptor down regulates the expression of cytochrome P450 in cultured rat hepatocytes
    • Nov
    • Tinel M, Robin MA, Doostzadeh J, et al. The interleukin-2 receptor down regulates the expression of cytochrome P450 in cultured rat hepatocytes. Gastroenterology 1995 Nov; 109 (5): 1589-99
    • (1995) Gastroenterology , vol.109 , Issue.5 , pp. 1589-1599
    • Tinel, M.1    Robin, M.A.2    Doostzadeh, J.3
  • 34
    • 0034307196 scopus 로고    scopus 로고
    • Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2
    • Oct
    • Peng HM, Coon MJ. Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2. Arch Biochem Biophys 2000 Oct; 382 (1): 129-37
    • (2000) Arch Biochem Biophys , vol.382 , Issue.1 , pp. 129-137
    • Peng, H.M.1    Coon, M.J.2
  • 35
    • 0029979369 scopus 로고    scopus 로고
    • Biologic basis for interleukin-1 in disease
    • Dianarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87: 2095-147
    • (1996) Blood , vol.87 , pp. 2095-2147
    • Dianarello, C.A.1
  • 36
    • 0034704880 scopus 로고    scopus 로고
    • Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    • published erratum appears in Nature 2001 Jul; 412 (6842): 99. Mar
    • El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer [published erratum appears in Nature 2001 Jul; 412 (6842): 99]. Nature 2000 Mar; 404 (6776): 398-402
    • (2000) Nature , vol.404 , Issue.6776 , pp. 398-402
    • El-Omar, E.M.1    Carrington, M.2    Chow, W.H.3
  • 37
    • 0035003571 scopus 로고    scopus 로고
    • Interleukin 1 polymorphisms, lifestyle factors, and Helicobacter pylori infection
    • Apr
    • Hamajima N, Matsuo K, Saito T, et al. Interleukin 1 polymorphisms, lifestyle factors, and Helicobacter pylori infection. Jpn J Cancer Res 2001 Apr; 92 (4): 383-9
    • (2001) Jpn J Cancer Res , vol.92 , Issue.4 , pp. 383-389
    • Hamajima, N.1    Matsuo, K.2    Saito, T.3
  • 38
    • 0035801718 scopus 로고    scopus 로고
    • Allelic expression and interleukin-2 polymorphisms in multiple sclerosis
    • Sep
    • Matesanz F, Fedetz M, Collado-Romero M, et al. Allelic expression and interleukin-2 polymorphisms in multiple sclerosis. J Neuroimmunol 2001 Sep; 119 (1): 101-5
    • (2001) J Neuroimmunol , vol.119 , Issue.1 , pp. 101-105
    • Matesanz, F.1    Fedetz, M.2    Collado-Romero, M.3
  • 39
    • 0036634761 scopus 로고    scopus 로고
    • Investigation of an IL-2 polymorphism in patients with different levels of chronic periodontitis
    • Jul
    • Scarel-Caminaga RM, Trevilatto PC, Souza AP, et al. Investigation of an IL-2 polymorphism in patients with different levels of chronic periodontitis. J Clin Periodontol 2002 Jul; 29 (7): 587-91
    • (2002) J Clin Periodontol , vol.29 , Issue.7 , pp. 587-591
    • Scarel-Caminaga, R.M.1    Trevilatto, P.C.2    Souza, A.P.3
  • 40
    • 0034048010 scopus 로고    scopus 로고
    • A polymorphism of the 5′ flanking region of tumour necrosis factor α gene is associated with thyroid-associated ophthalmopathy in Japanese
    • Jun
    • Kamizono S, Hiromatsu Y, Seki N, et al. A polymorphism of the 5' flanking region of tumour necrosis factor a gene is associated with thyroid-associated ophthalmopathy in Japanese. Clin Endocrinol 2000 Jun; 52 (6): 759-64
    • (2000) Clin Endocrinol , vol.52 , Issue.6 , pp. 759-764
    • Kamizono, S.1    Hiromatsu, Y.2    Seki, N.3


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