RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma

Gut

Volumn 39, Issue 2, 1996, Pages 330-333

  Ladero, J M ^a,c   Agundez J A G ^b   Rodriguez Lescure A ^a   Diaz Rubio, M ^a   Benitez J ^b  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b UNIVERSITY OF EXTREMADURA   (Spain)

^c NONE   (Spain)

Author keywords

CYP2E1; Ethanol; Hepatocellular carcinoma; P4502E1; Polymorphism

Indexed keywords

CYTOCHROME P450 ISOENZYME;

ADULT; AGED; ALLELE; ARTICLE; CANCER RISK; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; LIVER CARCINOMA; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0029793680     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.39.2.330     Document Type: Article

References (32)

1. Perrot N, Nalpas B, Yang CS, Beaune PH. Modulation of cytochrome-P450 isozymes in human liver by ethanol and drug intake. Eur J Clin Invest 1989; 19: 549-55.
2. Takayashi T, Lasker JM, Rosman AS, Lieber CS. Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 1993; 17: 236-45.
3. Guengerich FP, Kin D-H, Iwasaki M. Role of human cytochrome P-450IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 1991; 4: 168-79.
4. Yang CS, Yoo J-SH, Ishizaki H, Hong J. Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanism of regulation. Drug Metabol Rev 1990; 22: 147-59.
5. Lieber CS, Garro A, Leo MA, Mak KM, Worner TM. Alcohol and cancer. Hepatology 1986; 6: 1005-19.
6. Ruiz J, Sangro B, Cuende JI, Beloqui O, Riezu-Boj JI, Herrero JI, et al. Hepatitis B and C viral infections in patients with hepatocellular carcinoma. Hepatology 1992; 16: 637-41.
7. Liang TJ, Jeffers LJ, Reddy KR, de Medina M, Parker IT, Cheinquer H, et al. Viral pathogenesis of hepatocellular carcinoma in the United States. Hepatology 1993; 18: 1326-33.
8. Tsai JF, Chang WY, Jeng JE, Ho MS, Lin ZY, Tsai JH. Hepatitis B and C virus infection as risk factors for liver cirrhosis and cirrhotic hepatocellular carcinoma: A case-control study. Liver 1994; 14: 98-102.
9. Austin H, Delzell E, Grufferman S, Levine R, Morrison AS, Stolley PD, et al. A case-control study of hepatocellular carcinoma and the hepatitis B virus, cigarette smoking, and alcohol consumption. Cancer Res 1986; 46: 962-6.
10. Hisng AW, McLaughlin JH, Hrubec Z, Blot WJ, Fraumeni JF. Cigarette smoking and liver cancer among US veterans. Cancer Causes Control 1990; 1: 217-21.
11. Tsukuma H, Hiyama T, Tanaka S, Nakao M, Yabuuchi T, Kitamura T, et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993; 328: 1797-801.
12. Lieber CS. Alcohol and the liver: 1994 update. Gastroenterology 1994; 106: 1085-105.
13. Hayashi S-I, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem 1991; 110: 559-65.
14. Kim RB, O'Shea D, Wilkinson GR. Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone: a putative measure of CYP2E1 activity. Pharmacogenetics 1994; 4: 162-5.
15. Stephens EA, Taylor JA, Kaplan N, Yang CH, Hsieh LI, Lucier GW, et al. Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, Europeans-Americans and Taiwanese. Pharmacogenetics 1994; 4: 185-92.
16. Kato S, Shields PG, Caporaso NE, Hoover RN, Trump BF, Sugimura H, et al. Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer risk. Cancer Res 1992; 52: 6712-5.
17. Persson I, johanson I, Bergling H, Dahl M-J, Seidegard J, Rylander R, et al. Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer. FEBS Letters 1993; 319: 207-11.
18. Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber SC. The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. Hepatology 1989; 10: 437-46.
19. Pequignot G, Tuyns AJ, Berta JL. Ascitic cirrhosis in relation to alcohol consumption, Int J Epidemiol 1978; 7: 113-20.
20. Sherlock S. Alcoholic liver disease. Lancet 1995; 345: 227-9.
21. Neitzel HA. A routine method for the establishment of permanent growing lymphoblastoid cell lines. Hum Genet 1986; 73: 320-2.
22. Agúndez JAG, Ledesma MC, Benitez J, Ladero JM, Rodriguez-Lescure A, Diaz-Rubio E, et al. CYP2D6 genes and risk of liver cancer. Lancet 1995; 345: 830-1.
23. Yu M-W, Gladek-Tarborough A, Chiamprasert S, Santella RM, Liaw Y-F, Chen C-J. Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and sus-ceptibility to hepatocellular carcinoma. Gastroenterology 1995; 109: 1266-73.
24. 1. Proc Natl Acad Sci USA 1990; 87: 4790-3.
25. Yang CS, Yoo J-SH, Ishizaki H, Hong J. Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation. Drug Metab Rev 1990; 22: 147-59.
26. Tsutsumi M, Matsuda Y, Takada A. Role of ethanol-inducible cytochrome P-450 2E1 in the development of hepatocellular carcinoma by the chemical carcinogen, N-nitrosodimethylamine. Hepatology 1993; 18: 1483-9.
27. Takahashi T, Lasker JM, Rosman AS, Lieber CS. Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 1993; 17: 236-45.
28. Lucas D, Ménez C, Girre C, Benhou F, Bodénez P, Joannet I, et al. Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects Pharmacogenetics 1995; 5: 298-304.
29. Vesell ES, Seaton TD, A-Rahim YI. Studies on inter-individual variations of CYP2E1 using chlorzoxazone as an in vivo probe. Pharmacogenetics 1995; 5: 53-7.
30. Ono S, Hatanaka T, Hotta H, Tsutsui M, Satoh T, Gonzalez FJ. Chlorzoxazone in metabolized by human CYP1A2 as well as by human CTP2E1. Pharmacogenetics 1995; 5: 143-50.
31. Ingelman-Sundberg M, Johanson I, Yin H, Terelius Y, Eliasson E, Clot P, et al. Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease. Alcohol 1993; 10: 447-52.
32. Carr LG, Hartleroad JY, Liang Y, Mendenhall C, Moritz T, Thomasson H. Polymorphism at the P450IIE1 locus is not associated with alcoholic liver disease in Caucasian men. Alcohol Clin Exp Res 1995; 19: 182-4.