Insurmountable AT1 receptor antagonism: Message in a model? [2]

Trends in Pharmacological Sciences

Volumn 22, Issue 11, 2001, Pages 555-557

  Lew, Michael ^a   Christopoulos, Arthur ^a   Ziogas, James ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; INOSITOL PHOSPHATE; RADIOLIGAND; ANGIOTENSIN RECEPTOR;

COMPARATIVE STUDY; DISSOCIATION; DRUG EFFICACY; DRUG SENSITIVITY; LETTER; LIGAND BINDING; MODEL; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION; TIME; BIOLOGICAL MODEL; DRUG ANTAGONISM; DRUG POTENTIATION; KINETICS; NOTE;

KINETICS; MODELS, BIOLOGICAL; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN;

EID: 0035497744     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01826-5     Document Type: Letter

References (7)

1. 1 receptor antagonism: The need for different antagonist binding states of the receptor
2. 1 receptor antagonists
3. A two-state receptor model for the interaction between angiotensin II type 1 receptors and non-peptide antagonists
4. The kinetics of action of acetylcholine antagonists in smooth muscle
5. Non-surmountable antagonism: A general drawback of pre-steady-state measurement?
6. Non-surmountable antagonism: Transcending steady state
7. Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stoichiometry