The two-state model of antagonist-AT1 receptor interaction: An hypothesis defended but not tested

Biochemical Pharmacology

Volumn 67, Issue 3, 2004, Pages 397-399

  Lew, Michael J ^a   Ziogas, James ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST;

BINDING AFFINITY; COMPARATIVE STUDY; CORRELATION ANALYSIS; DISSOCIATION; DRUG ANTAGONISM; EXPERIMENTAL MODEL; LIGAND BINDING; MATHEMATICAL MODEL; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW;

EID: 1242286395     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.11.007     Document Type: Note

References (5)

1. 1 receptor interaction: further support by binding studies at low temperature. Biochem. Pharmacol. 65:2003;1339-1341.
2. 1 receptor antagonists. Trends Pharmacol. Sci. 21:2000;376-381.
3. Lew M.J., Christopoulos A., Ziogas J. Non-surmountable antagonism: transcending steady state. Trends Pharmacol. Sci. 22:2001;65-66.
4. 1 receptor antagonism: message in a model? Trends Pharmacol. Sci. 22:2001;555-557.
5. Vauquelin G., Morsing P., Fierens F.L.P., De Backer J.-P., Vanderheyden P.M.L. A two-state receptor model for the interaction between angiotensin II type 1 receptors and non-peptide antagonists. Biochem. Pharmacol. 61:2001;277-284.