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Volumn 9, Issue 6, 2005, Pages 594-602

Riboswitches and the role of noncoding RNAs in bacterial metabolic control

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; BACTERIAL RNA; CIS ACTING ELEMENT; COBAMAMIDE; COCARBOXYLASE; FLAVINE MONONUCLEOTIDE; GLUCOSAMINE 6 PHOSPHATE; GLUCOSAMINE DERIVATIVE; GLYCINE; GUANINE; LYSINE; MESSENGER RNA; S ADENOSYLMETHIONINE; TRANS ACTING FACTOR; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

EID: 27744519876     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2005.09.016     Document Type: Review
Times cited : (103)

References (47)
  • 1
    • 17444403921 scopus 로고    scopus 로고
    • Metabolic monitoring by bacterial mRNAs
    • W.C. Winkler Metabolic monitoring by bacterial mRNAs Arch Microbiol 183 2005 151 159
    • (2005) Arch Microbiol , vol.183 , pp. 151-159
    • Winkler, W.C.1
  • 2
    • 4344682527 scopus 로고    scopus 로고
    • The small RNA regulators of Escherichia coli: Roles and mechanisms
    • S. Gottesman The small RNA regulators of Escherichia coli: roles and mechanisms Annu Rev Microbiol 58 2004 303 328
    • (2004) Annu Rev Microbiol , vol.58 , pp. 303-328
    • Gottesman, S.1
  • 4
    • 0347418195 scopus 로고    scopus 로고
    • Riboswitches: The oldest mechanism for the regulation of gene expression?
    • A.G. Vitreschak, D.A. Rodionov, A.A. Mironov, and M.S. Gelfand Riboswitches: the oldest mechanism for the regulation of gene expression? Trends Genet 20 2004 44 50
    • (2004) Trends Genet , vol.20 , pp. 44-50
    • Vitreschak, A.G.1    Rodionov, D.A.2    Mironov, A.A.3    Gelfand, M.S.4
  • 5
    • 0017232521 scopus 로고
    • Coenzymes as fossils of an earlier metabolic state
    • HB. White III Coenzymes as fossils of an earlier metabolic state J Mol Evol 7 1976 101 104
    • (1976) J Mol Evol , vol.7 , pp. 101-104
    • White III, H.B.1
  • 6
    • 9244225713 scopus 로고    scopus 로고
    • Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine
    • R.T. Batey, S.D. Gilbert, and R.K. Montange Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine Nature 432 2004 411 415 Crystallographic structure of the B. subtilis xpt riboswitch bound to hypoxanthine. These data confirm structural elements predicted by comparative sequence analyses and help explain the roles of conserved nucleotides in building the aptamer structure. Furthermore, they demonstrate how ligand-induced stabilization of a binding pocket can influence formation of an anti-terminator element.
    • (2004) Nature , vol.432 , pp. 411-415
    • Batey, R.T.1    Gilbert, S.D.2    Montange, R.K.3
  • 7
    • 10644250950 scopus 로고    scopus 로고
    • Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs
    • A. Serganov, Y.R. Yuan, O. Pikovskaya, A. Polonskaia, L. Malinina, A.T. Phan, C. Hobartner, R. Micura, R.R. Breaker, and D.J. Patel Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs Chem Biol 11 2004 1729 1741 Crystallographic structures of adenine and guanine-sensing aptamers reveal that recognition of the two nucleobases is identical except for a specificity-determining pyrimidine that pairs with the Watson-Crick face of the purine ligand.
    • (2004) Chem Biol , vol.11 , pp. 1729-1741
    • Serganov, A.1    Yuan, Y.R.2    Pikovskaya, O.3    Polonskaia, A.4    Malinina, L.5    Phan, A.T.6    Hobartner, C.7    Micura, R.8    Breaker, R.R.9    Patel, D.J.10
  • 8
    • 15944382675 scopus 로고    scopus 로고
    • The speed of RNA transcription and metabolite binding kinetics operate an FMN riboswitch
    • ••], an RNAP pause site was found to be adjacent to sequences required for formation of terminator and anti-terminator helices.
    • (2005) Mol Cell , vol.18 , pp. 49-60
    • Wickiser, J.K.1    Winkler, W.C.2    Breaker, R.R.3    Crothers, D.M.4
  • 9
    • 2342511433 scopus 로고    scopus 로고
    • New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control
    • J.E. Barrick, K.A. Corbino, W.C. Winkler, A. Nahvi, M. Mandal, J. Collins, M. Lee, A. Roth, N. Sudarsan, and I. Jona New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control Proc Natl Acad Sci USA 101 2004 6421 6426 A bioinformatics-aided identification of novel noncoding RNAs that are highly conserved in bacteria. This manuscript nearly doubled the total number of likely riboswitches.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6421-6426
    • Barrick, J.E.1    Corbino, K.A.2    Winkler, W.C.3    Nahvi, A.4    Mandal, M.5    Collins, J.6    Lee, M.7    Roth, A.8    Sudarsan, N.9    Jona, I.10
  • 10
    • 23144463910 scopus 로고    scopus 로고
    • RibEx: A web server for locating riboswitches and other conserved bacterial regulatory elements
    • C. Abreu-Goodger, and E. Merino RibEx: a web server for locating riboswitches and other conserved bacterial regulatory elements Nucleic Acids Res 33 2005 W690 W692
    • (2005) Nucleic Acids Res , vol.33
    • Abreu-Goodger, C.1    Merino, E.2
  • 11
    • 1642586299 scopus 로고    scopus 로고
    • Control of gene expression by a natural metabolite-responsive ribozyme
    • W.C. Winkler, A. Nahvi, A. Roth, J.A. Collins, and R.R. Breaker Control of gene expression by a natural metabolite-responsive ribozyme Nature 428 2004 281 286 Biochemical demonstration that the GlcN6P-sensing riboswitch is a self-cleaving ribozyme. It is the first ribozyme discovered in over a decade and is likely to serve as a good model for ribozyme-mediated control of gene expression.
    • (2004) Nature , vol.428 , pp. 281-286
    • Winkler, W.C.1    Nahvi, A.2    Roth, A.3    Collins, J.A.4    Breaker, R.R.5
  • 12
    • 0842334528 scopus 로고    scopus 로고
    • Adenine riboswitches and gene activation by disruption of a transcription terminator
    • M. Mandal, and R.R. Breaker Adenine riboswitches and gene activation by disruption of a transcription terminator Nat Struct Mol Biol 11 2004 29 35
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 29-35
    • Mandal, M.1    Breaker, R.R.2
  • 13
    • 0346366823 scopus 로고    scopus 로고
    • Thiamine-regulated gene expression of Aspergillus oryzae thiA requires splicing of the intron containing a riboswitch-like domain in the 5′-UTR
    • T. Kubodera, M. Watanabe, K. Yoshiuchi, N. Yamashita, A. Nishimura, S. Nakai, K. Gomi, and H. Hanamoto Thiamine-regulated gene expression of Aspergillus oryzae thiA requires splicing of the intron containing a riboswitch-like domain in the 5′-UTR FEBS Lett 555 2003 516 520
    • (2003) FEBS Lett , vol.555 , pp. 516-520
    • Kubodera, T.1    Watanabe, M.2    Yoshiuchi, K.3    Yamashita, N.4    Nishimura, A.5    Nakai, S.6    Gomi, K.7    Hanamoto, H.8
  • 14
    • 17844379221 scopus 로고    scopus 로고
    • 6S RNA is a widespread regulator of eubacterial RNA polymerase that resembles an open promoter
    • J.E. Barrick, N. Sudarsan, Z. Weinberg, W.L. Ruzzo, and R.R. Breaker 6S RNA is a widespread regulator of eubacterial RNA polymerase that resembles an open promoter RNA 11 2005 774 784
    • (2005) RNA , vol.11 , pp. 774-784
    • Barrick, J.E.1    Sudarsan, N.2    Weinberg, Z.3    Ruzzo, W.L.4    Breaker, R.R.5
  • 15
    • 18344371528 scopus 로고    scopus 로고
    • A highly conserved 6S RNA structure is required for regulation of transcription
    • A.E. Trotochaud, and K.M. Wassarman A highly conserved 6S RNA structure is required for regulation of transcription Nat Struct Mol Biol 12 2005 313 319
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 313-319
    • Trotochaud, A.E.1    Wassarman, K.M.2
  • 16
    • 17144365857 scopus 로고    scopus 로고
    • Experimetnal RNomics in Aquifex aeolicus: Identification of small non-coding RNAs and the putative 6S RNA homolog
    • D.K. Willkomm, J. Minnerup, A. Huttenhofer, and R.K. Hartmann Experimetnal RNomics in Aquifex aeolicus: identification of small non-coding RNAs and the putative 6S RNA homolog Nucleic Acids Res 33 2005 1949 1960
    • (2005) Nucleic Acids Res , vol.33 , pp. 1949-1960
    • Willkomm, D.K.1    Minnerup, J.2    Huttenhofer, A.3    Hartmann, R.K.4
  • 17
    • 5044234799 scopus 로고    scopus 로고
    • A glycine-dependent riboswitch that uses cooperative binding to control gene expression
    • M. Mandal, M. Lee, J.E. Barrick, Z. Weinberg, G.M. Emilsson, W.L. Ruzzo, and R.R. Breaker A glycine-dependent riboswitch that uses cooperative binding to control gene expression Science 306 2004 275 279 A glycine-responsive riboswitch, identified through bioinformatics-assisted methodology, is shown to bind two molecules of glycine in a cooperative fashion, providing an explanation for its 'digital-like' control of gene expression.
    • (2004) Science , vol.306 , pp. 275-279
    • Mandal, M.1    Lee, M.2    Barrick, J.E.3    Weinberg, Z.4    Emilsson, G.M.5    Ruzzo, W.L.6    Breaker, R.R.7
  • 18
    • 0038136962 scopus 로고    scopus 로고
    • Metabolite-binding RNA domains are present in the genes of eukaryotes
    • N. Sudarsan, J.E. Barrick, and R.R. Breaker Metabolite-binding RNA domains are present in the genes of eukaryotes RNA 9 2003 644 647
    • (2003) RNA , vol.9 , pp. 644-647
    • Sudarsan, N.1    Barrick, J.E.2    Breaker, R.R.3
  • 19
    • 0142075327 scopus 로고    scopus 로고
    • Genetic control by metabolite-binding riboswitches
    • W.C. Winkler, and R.R. Breaker Genetic control by metabolite-binding riboswitches ChemBioChem 4 2003 1024 1032
    • (2003) ChemBioChem , vol.4 , pp. 1024-1032
    • Winkler, W.C.1    Breaker, R.R.2
  • 21
    • 0346687595 scopus 로고    scopus 로고
    • The riboswitch control of bacterial metabolism
    • E. Nudler, and A.S. Mironov The riboswitch control of bacterial metabolism Trends Biochem Sci 29 2004 11 17
    • (2004) Trends Biochem Sci , vol.29 , pp. 11-17
    • Nudler, E.1    Mironov, A.S.2
  • 22
    • 1842558364 scopus 로고    scopus 로고
    • Regulation of gene expression by effectors that bind to RNA
    • F.J. Grundy, and T.M. Henkin Regulation of gene expression by effectors that bind to RNA Curr Opin Microbiol 7 2004 126 131
    • (2004) Curr Opin Microbiol , vol.7 , pp. 126-131
    • Grundy, F.J.1    Henkin, T.M.2
  • 23
    • 0042320361 scopus 로고    scopus 로고
    • An mRNA structure that controls gene expression by binding S-adenosylmethionine
    • W.C. Winkler, A. Nahvi, N. Sudarsan, J.E. Barrick, and R.R. Breaker An mRNA structure that controls gene expression by binding S-adenosylmethionine Nat Struct Biol 10 2003 701 707
    • (2003) Nat Struct Biol , vol.10 , pp. 701-707
    • Winkler, W.C.1    Nahvi, A.2    Sudarsan, N.3    Barrick, J.E.4    Breaker, R.R.5
  • 24
    • 0036753365 scopus 로고    scopus 로고
    • Genetic control by a metabolite binding mRNA
    • A. Nahvi, N. Sudarsan, M.S. Ebert, X. Zou, K.L. Brown, and R.R. Breaker Genetic control by a metabolite binding mRNA Chem Biol 9 2002 1043 1049 The initial publication providing biochemical evidence for metabolite-sensing riboswitches. In-line probing is established as a method for studying ligand-induced conformational changes.
    • (2002) Chem Biol , vol.9 , pp. 1043-1049
    • Nahvi, A.1    Sudarsan, N.2    Ebert, M.S.3    Zou, X.4    Brown, K.L.5    Breaker, R.R.6
  • 25
    • 0037453069 scopus 로고    scopus 로고
    • Transcription termination control of the S box system: Direct measurements of S-adenosylmethionine by the leader RNA
    • B.A. McDaniel, F.J. Grundy, I. Artsimovitch, and T.M. Henkin Transcription termination control of the S box system: direct measurements of S-adenosylmethionine by the leader RNA Proc Natl Acad Sci USA 100 2003 3083 3088
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3083-3088
    • McDaniel, B.A.1    Grundy, F.J.2    Artsimovitch, I.3    Henkin, T.M.4
  • 28
    • 0037206833 scopus 로고    scopus 로고
    • Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression
    • W. Winkler, A. Nahvi, and R.R. Breaker Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression Nature 419 2002 952 956
    • (2002) Nature , vol.419 , pp. 952-956
    • Winkler, W.1    Nahvi, A.2    Breaker, R.R.3
  • 30
    • 3242881589 scopus 로고    scopus 로고
    • Riboswitch finder - A tool for identification of riboswitch RNAs
    • P. Bengert, and T. Dandekar Riboswitch finder - a tool for identification of riboswitch RNAs Nucleic Acids Res 32 2004 W154 W159
    • (2004) Nucleic Acids Res , vol.32
    • Bengert, P.1    Dandekar, T.2
  • 31
    • 2242446202 scopus 로고    scopus 로고
    • Comparative genomics of thiamin biosynthesis in prokaryotes. New genes and regulatory mechanisms
    • ••,34 ], demonstrates how identification of cis-acting regulatory elements can assist in prediction of gene function for uncharacterized downstream genes. TPP-sensing riboswitches are used to predict missing transport and biosynthesis enzymes.
    • (2002) J Biol Chem , vol.277 , pp. 48949-48959
    • Rodionov, D.A.1    Vitreschak, A.G.2    Mironov, A.A.3    Gelfand, M.S.4
  • 33
    • 3042639887 scopus 로고    scopus 로고
    • Comparative genomics of the methionine metabolism in Gram-positive bacteria: A variety of regulatory systems
    • D.A. Rodionov, A.G. Vitreschak, A.A. Mironov, and M.S. Gelfand Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems Nucleic Acids Res 32 2004 3340 3353 Cis-acting regulatory elements are used to assist in prediction of gene function. Interestingly, certain lineages of bacteria are found to use tRNA-sensing RNAs for regulation of genes that are regulated by SAM-sensing RNAs in other lineages.
    • (2004) Nucleic Acids Res , vol.32 , pp. 3340-3353
    • Rodionov, D.A.1    Vitreschak, A.G.2    Mironov, A.A.3    Gelfand, M.S.4
  • 34
    • 0037100667 scopus 로고    scopus 로고
    • Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation
    • A.G. Vitreschak, D.A. Rodionov, A.A. Mironov, and M.S. Gelfand Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation Nucleic Acids Res 30 2002 3141 3151
    • (2002) Nucleic Acids Res , vol.30 , pp. 3141-3151
    • Vitreschak, A.G.1    Rodionov, D.A.2    Mironov, A.A.3    Gelfand, M.S.4
  • 35
    • 0042890402 scopus 로고    scopus 로고
    • Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL)
    • L.E. Johansen, P. Nygaard, C. Lassen, Y. Agerso, and H.H. Saxild Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL) J Bacteriol 185 2003 5200 5209
    • (2003) J Bacteriol , vol.185 , pp. 5200-5209
    • Johansen, L.E.1    Nygaard, P.2    Lassen, C.3    Agerso, Y.4    Saxild, H.H.5
  • 36
    • 0038210214 scopus 로고    scopus 로고
    • Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria
    • M. Mandal, B. Boese, J.E. Barrick, W.C. Winkler, and R.R. Breaker Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria Cell 113 2003 577 586
    • (2003) Cell , vol.113 , pp. 577-586
    • Mandal, M.1    Boese, B.2    Barrick, J.E.3    Winkler, W.C.4    Breaker, R.R.5
  • 37
    • 13444271576 scopus 로고    scopus 로고
    • An intermolecular base triple as the basis of ligand specificity and affinity in the guanine- and adenine-sensing riboswitch RNAs
    • J. Noeske, C. Richter, M.A. Grundl, H.R. Nasiri, H. Schwalbe, and J. Wohnert An intermolecular base triple as the basis of ligand specificity and affinity in the guanine- and adenine-sensing riboswitch RNAs Proc Natl Acad Sci USA 102 2005 1372 1377
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1372-1377
    • Noeske, J.1    Richter, C.2    Grundl, M.A.3    Nasiri, H.R.4    Schwalbe, H.5    Wohnert, J.6
  • 38
    • 0037143667 scopus 로고    scopus 로고
    • NusA-stimulated RNA polymerase pausing and termination participates in the Bacillus subtilis trp operon attenuation mechanism in vitro
    • A.V. Yakhnin, and P. Babitzke NusA-stimulated RNA polymerase pausing and termination participates in the Bacillus subtilis trp operon attenuation mechanism in vitro Proc Natl Acad Sci USA 99 2002 11067 11072 Careful demonstration of NusA-induced, hairpin-dependent pause signals that appear to be functionally involved in TRAP attenuation. The observation of a pause site adjacent to anti-terminator and terminator sequence elements led to similar observations with other mechanisms, and may be a common feature in transcription attenuation systems.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11067-11072
    • Yakhnin, A.V.1    Babitzke, P.2
  • 39
    • 0042060984 scopus 로고    scopus 로고
    • Transcriptional pausing in the Bacillus subtilis pyr operon in vitro: A role in transcriptional attenuation?
    • H. Zhang, and R.L. Switzer Transcriptional pausing in the Bacillus subtilis pyr operon in vitro: a role in transcriptional attenuation? J Bacteriol 185 2003 4764 4771
    • (2003) J Bacteriol , vol.185 , pp. 4764-4771
    • Zhang, H.1    Switzer, R.L.2
  • 40
    • 12344255940 scopus 로고    scopus 로고
    • Monitoring uncharged tRNA during transcription of the Bacillus subtilis glyQS gene
    • F.J. Grundy, M.R. Yousef, and T.M. Henkin Monitoring uncharged tRNA during transcription of the Bacillus subtilis glyQS gene J Mol Biol 346 2005 73 81 These data demonstrate that T box RNAs (tRNA-sensing regulatory RNAs) can form productive interactions with tRNA effectors all the way up to the commitment step of formation of the terminator helix. Additionally, folding of the T box RNA into its functional form does not require the presence of the tRNA effector.
    • (2005) J Mol Biol , vol.346 , pp. 73-81
    • Grundy, F.J.1    Yousef, M.R.2    Henkin, T.M.3
  • 41
    • 3843118724 scopus 로고    scopus 로고
    • Kinetic analysis of tRNA-directed transcription antitermination of the Bacillus subtilis glyQS gene in vitro
    • F.J. Grundy, and T.M. Henkin Kinetic analysis of tRNA-directed transcription antitermination of the Bacillus subtilis glyQS gene in vitro J Bacteriol 186 2004 5392 5399
    • (2004) J Bacteriol , vol.186 , pp. 5392-5399
    • Grundy, F.J.1    Henkin, T.M.2
  • 42
    • 0142152455 scopus 로고    scopus 로고
    • A transcriptional pause synchronizes translation with transcription in the tryptophanase operon leader region
    • F. Gong, and C. Yanofsky A transcriptional pause synchronizes translation with transcription in the tryptophanase operon leader region J Bacteriol 185 2003 6472 6476
    • (2003) J Bacteriol , vol.185 , pp. 6472-6476
    • Gong, F.1    Yanofsky, C.2
  • 43
    • 9644270488 scopus 로고    scopus 로고
    • Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination
    • A. Teixeira, A. Tahiri-Alaoui, S. West, B. Thomas, A. Ramadass, I. Martianov, M. Dye, W. James, N.J. Proudfoot, and A. Akoulitchev Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination Nature 432 2004 526 530 A conserved self-cleaving ribozyme is found to be required for transcription termination of β-globin transcripts. The self-cleaving reaction appears to generate products with 3′ -hydroxy and 5′ -phosphate ends. Kinetics of cleavage appear to be complex and it remains to be determined whether the ribozyme is responsive to any intracellular signals.
    • (2004) Nature , vol.432 , pp. 526-530
    • Teixeira, A.1    Tahiri-Alaoui, A.2    West, S.3    Thomas, B.4    Ramadass, A.5    Martianov, I.6    Dye, M.7    James, W.8    Proudfoot, N.J.9    Akoulitchev, A.10
  • 45
    • 3042808647 scopus 로고    scopus 로고
    • A protein-dependent riboswitch controlling ptsGHI operon expression in Bacillus subtilis: RNA structure rather than sequence provides interaction specificity
    • O. Schilling, I. Langbein, M. Müller, M.H. Schmalisch, and J. Stülke A protein-dependent riboswitch controlling ptsGHI operon expression in Bacillus subtilis: RNA structure rather than sequence provides interaction specificity Nucleic Acids Res 32 2004 2853 2864
    • (2004) Nucleic Acids Res , vol.32 , pp. 2853-2864
    • Schilling, O.1    Langbein, I.2    Müller, M.3    Schmalisch, M.H.4    Stülke, J.5
  • 46
    • 0037031594 scopus 로고    scopus 로고
    • An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes
    • J. Johansson, P. Mandin, A. Renzoni, C. Chiaruttini, M. Springer, and P. Cossart An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes Cell 110 2002 551 561
    • (2002) Cell , vol.110 , pp. 551-561
    • Johansson, J.1    Mandin, P.2    Renzoni, A.3    Chiaruttini, C.4    Springer, M.5    Cossart, P.6
  • 47
    • 0038187589 scopus 로고    scopus 로고
    • Small noncoding RNAs, coordinators of adaptation processes in Escherichia coli: The RpoS paradigm
    • F. Repoila, N. Majdalani, and S. Gottesman Small noncoding RNAs, coordinators of adaptation processes in Escherichia coli: the RpoS paradigm Mol Microbiol 48 2003 855 861
    • (2003) Mol Microbiol , vol.48 , pp. 855-861
    • Repoila, F.1    Majdalani, N.2    Gottesman, S.3


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