Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL)

Journal of Bacteriology

Volumn 185, Issue 17, 2003, Pages 5200-5209

  Johansen, Lars Engholm ^a   Nygaard, Per ^b   Lassen, Catharina ^b   Agersø, Yvonne ^a   Saxild, Hans H ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUOROADENINE; CARRIER PROTEIN; GUANINE; HYPOXANTHINE; HYPOXANTHINE GUANINE TRANSPORTER; PURINE NUCLEOSIDE; PURINE NUCLEOSIDE TRANSPORTER; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIUM CULTURE; BACTERIUM ISOLATE; BACTERIUM MUTANT; CONTROLLED STUDY; CULTURE MEDIUM; GENE CONTROL; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE STRUCTURE; GENETIC CODE; GENETIC TRANSCRIPTION; GLYA GENE; GUAC GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUPG GENE; OPERON; PBUE GENE; PBUG GENE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PURINE SYNTHESIS; REGULON; SEQUENCE ANALYSIS; TANDEM REPEAT; TRANSCRIPTION TERMINATION; XPT PBUX GENE; YDHL GENE;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; GENE EXPRESSION REGULATION, BACTERIAL; GUANINE; HYPOXANTHINES; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; OPERON; PURINES; REGULON; SEQUENCE ANALYSIS, DNA;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0042890402     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.185.17.5200-5209.2003     Document Type: Article

References (33)

1. Arnvig, K., B. Hove-Jensen, and R. L. Switzer. 1990. Purification and properties of phosphoribosyl-diphosphate synthetase from Bacillus subtilis. Eur. J. Biochem. 192:195-200.
2. Bonner, E. R., J. N. D'Elia, B. K. Billips, and R. L. Switzer. 2001. Molecular recognition of pyr mRNA by the Bacillus subtilis attenuation regulatory protein PyrR. Nucleic Acids Res. 29:4851.
3. Christiansen, L. C., S. Schou, P. Nygaard, and H. H. Saxild. 1997. Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism. J. Bacteriol. 179:2540-2550.
4. Ebbole, D. J., and H. Zalkin. 1987. Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide biosynthesis. J. Biol. Chem. 262:8274-8287.
5. Ebbole, D. J., and H. Zalkin. 1988. Characterization of the Bacillus subtilis pur operon: new insights into gene regulation, p. 51-55. In J. A. Hoch (ed.), Genetics and biotechnology of bacilli, vol. 2. Academic Press Inc., New York, N.Y.
6. Ebbole, D. J., and H. Zalkin. 1988. Detection of pur operon-attenuated mRNA and accumulated degradation intermediates in Bacillus subtilis. J. Biol. Chem. 263:10894-10902.
7. Ghim, S.-Y., and R. L. Switzer. 1996. Characterization of cis-acting mutations in the first attenuator region of the Bacillus subtilis pyr operon that are defective in pyrimidine-mediated regulation of expression. J. Bacteriol. 178:2351-2355.
8. Grundy, F. J., W. C. Winkler, and T. M. Henkin. 2002. tRNA-mediated transcription antitermination in vitro: codon-anticodon pairing independent of the ribosome. Proc. Natl. Acad. Sci. USA 99:11121.
9. Ishii, K., and I. Shiio. 1970. Regulation of purine ribonucleotide synthesis by end product inhibition. III. Effect of purine nucleotides on succino-AMP synthetase of Bacillus subtilis. J. Biochem. 68:171-176.
10. Jochimsen, B., P. Nygaard, and T. Vestergaard. 1975. Location on the chromosome of Escherichia coli of genes governing purine metabolism. Mol. Gen. Genet. 143:85-91.
11. Kuninaka, A. 1986. Nucleic acids, nucleotides, and related compounds, p. 71-114. In H. J. Rehm and G. Reed (ed.), Bio/technology. VCH Verlagsgesellschaft, Weinheim, Germany.
12. Kunst, F., N. Ogasawara, I. Moszer, A. M. Albertini, G. Alloni, V. Azevedo, M. G. Bertero, P. Bessieres, A. Bolotin, S. Borchert, R. Borriss, L. Boursier, A. Brans, M. Braun, S. C. Brignell, S. Bron, S. Broulliet, C. V. Bruschi, B. Caldwell, V. Capuano, N. M. Carter, S. K. Choi, J. J. Codani, I. F. Connerton, A. Danchin, et al. 1997. The complete genome sequence of the Gram-positive bacterium Bacillus subtilis. Nature 390:249-256.
13. Lu, Y., R. J. Turner, and R. L. Switzer. 1996. Function of RNA secondary structures in transcriptional attenuation of the Bacillus subtilis pyr operon. Proc. Natl. Acad. Sci. USA 93:14462-14467.
14. McDaniel, B. A., F. J. Grundy, I. Artsimovitch, and T. M. Henkin. 2003. Transcription termination control of the S box system: direct measurement of S-adenosylmethionine by the leader RNA. Proc. Natl. Acad. Sci. USA 100:3083-3088.
15. Meyer, E., and R. L. Switzer. 1979. Regulation of n-glutamine phosphoribosylpyrophosphate amidotransferase activity by end products. J. Biol. Chem. 254:5397-5402.
16. Mironov, A. S., I. Gusarov, R. Rafikov, L. E. Lopez, K. Shatalin, R. A. Kreneva, D. A. Perumov, and E. Nudler. 2002. Sensing small molecules by nascent RNA. A mechanism to control transcription in bacteria. Cell 111:747-756.
17. Nygaard, P. 1983. Utilization of preformed purine bases and nucleosides, p. 27-93. In A. Munch-Petersen (ed.), Metabolism of nucleotides, nucleosides and nucleobases in microorganisms. Academic Press, London, United Kingdom.
18. Nygaard, P. 1993. Purine and pyrimidine salvage pathways, p. 359-378. In A. L. Sonenshein, J. A. Hoch, and R. Losick (ed.), Bacillus subtilis and other gram-positive bacteria. American Society for Microbiology, Washington, D.C.
19. Nygaard, P., P. Duckert, and H. H. Saxild. 1996. Role of adenine deaminase in purine salvage and nitrogen metabolism and characterization of the ade gene in Bacillus subtilis. J. Bacteriol. 178:846-853.
20. Perkins, J. B., A. Sloma, T. Hermann, K. Theriault, E. Zachgo, T. Erdenberger, N. Hannett, N. P. Chatterjee, V. Williams II, G. A. Rufo, Jr., R. Hatch, and J. Pero. 1999. Genetic engineering of Bacillus subtilis for the commercial production of riboflavin. J. Ind. Microbiol.Bio/technol. 22:8-18.
21. Savacool, H. K., and R. L. Switzer. 2002. Characterization of the interaction of Bacillus subtilis PyrR with pyr mRNA by site-directed mutagenesis of the protein. J. Bacteriol. 184:2521-2528.
22. Saxild, H. H., L. N. Andersen, and K. Hammer. 1996. dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded DeoR repressor protein. J. Bacteriol. 178:424-434.
23. Saxild, H. H., K. Brunstedt, K. I. Nielsen, H. Jarmer, and P. Nygaard. 2001. Definition of the Bacillus subtilis PurR operator using genetic and bioinformatic tools and expansion of the PurR regulon with glyA, guaC, pbuG, xpt-pbuX, yqhZ-folD, and pbuO. J. Bacteriol. 183:6175-6183.
24. Saxild, H. H., J. H. Jacobsen, and P. Nygaard. 1995. Functional analysis of the Bacillus subtilis purT gene encoding formate-dependent glycinamide ribonucleotide transformylase. Microbiology 141:2211-2218.
25. Saxild, H. H., and P. Nygaard. 1987. Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs. J. Bacteriol. 169:2977-2983.
26. Saxild, H. H., and P. Nygaard. 1991. Regulation of levels of purine biosynthetic enzymes in Bacillus subtilis: effects of changing nucleotide pools. J. Gen. Microbiol. 137:2387-2394.
27. Shin, B. S., A. Stein, and H. Zalkin. 1997. Interaction of Bacillus subtilis purine repressor with DNA. J. Bacteriol. 179:7394-7402.
28. Vagner, V., E. Dervyn, and D. Ehrlich. 1998. A vector for systematic gene inactivation in Bacillus subtilis. Microbiology 144:3097-3104.
29. Weng, M., P. L. Nagy, and H. Zalkin. 1995. Identification of the Bacillus subtilis pur operon repressor. Proc. Natl. Acad. Sci. USA 92:7455-7459.
30. Winkler, W., A. Nahvi, and R. R. Breaker. 2002. Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression. Nature 419:952-959.
31. Winkler, W. C., S. Cohen-Chalamish, and R. R. Breaker. 2002. An mRNA structure that controls gene expression by binding FMN. Proc. Natl. Acad. Sci. USA 99:15908.
32. Wu, T. W., and K. G. Scrimgeour. 1973. Properties of inosinic acid dehydrogenase from Bacillis subtilis. II. Kinetic properties. Can. J. Biochem. 51:1391-1398.
33. Zeng, X., and H. H. Saxild. 1999. Identification and characterization of a DeoR-specific operator sequence essential for induction of dra-nupC-pdp operon expression in Bacillus subtilis. J. Bacteriol. 181:1719-1727.