Transcriptional regulation of the rat Mrp3 gene promoter by the specificity protein (Sp) family members and CCAAT/enhancer binding proteins

Journal of Biomedical Science

Volumn 12, Issue 5, 2005, Pages 741-761

  Tzeng, Shwu Jen ^a   Chang, Wen Chang ^a   Huang, Jin Ding ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

C EBP ; C EBP ; C EBP ; Rat Mrp3 regulation; Sp1; Sp3

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; CIS ACTING ELEMENT; MULTIDRUG RESISTANCE PROTEIN 3; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

ANIMAL CELL; ARTICLE; ASSAY; BINDING SITE; DROSOPHILA; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HEPATOMA CELL; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; TRANSLATION INITIATION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; LIVER; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PLASMIDS; PROMOTER REGIONS (GENETICS); RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR;

ANIMALIA;

EID: 27744517996     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/s11373-005-9002-5     Document Type: Article

References (36)

1. Keppler D., Jedlitschky G. and Leier I., Transport function and substrate specificity of multidrug resistance protein. Meth. Enzymol. 292: 607-616, 1998.
2. Ishikawa T., Allikimets R., Dean M., Higgins C., Ling V. and Wain H.M., New nomenclature of human ABC transporter genes. Xenobio. Metabol. Dispos. 15: 8-19, 2000.
3. Keppler D., Kamisako T., Leier I., Cui Y., Nies A.T., Tsujii H. and König J., Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family. Adv. Enzyme Regul. 40: 339-349, 2000.
4. Heid C.A., Stevens J., Livak K.J. and Williams P.M., Real time quantitative PCR. Genome Res. 6: 986-994, 1996.
5. Hirohashi T., Suzuki H., Ito K., Ogawa K., Kume K., Shimizu T. and Sugiyama Y., Hepatic expression of multidrug resistance-associated protein- like proteins maintained in Eisai hyperbilirubinemic rats. Mol. Pharmacol. 53: 1068-1075, 1998.
6. Kauffmann H.M., Keppler D., Kartenbeck J. and Schrenk D., Induction of cMRP/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes. Hepatology 26: 980-985, 1997.
7. König J., Rost D., Cui Y. and Keppler D., Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 29: 1156-1163, 1999.
8. Soroka C.J., Lee J.L., Azzaroli F. and Boyer J.L., Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 33: 783-791, 2001.
9. Hirohashi T., Suzuki H., Takikawa H. and Sugiyama Y., ATP dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J. Biol. Chem. 275: 2905-2910, 2000.
10. Inokuchi A., Hinoshita E., Iwamoto Y., Kohno K., Kuwano M. and Uchiumi T., Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. J. Biol. Chem. 276: 46822-46829, 2001.
11. Maglich J.M., Stoltz C.M., Goodwin B., Hawkins-Brown D., Moore J.T. and Kliewer S.A., Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol. Pharmacol. 62: 638-646, 2002.
12. Staudinger J.L., Madan A., Carol K.M. and Parkinson A., Regulation of drug transporter gene expression by nuclear receptors. Drug Metab. Dispos. 31: 523-527, 2003.
13. Xiong H., Yoshinari K., Brouwer K.L. and Negishi M., Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbitol. Drug Metab. Dispos. 30: 918-923, 2002.
14. Cherrington N.J., Hartley D.P., Li N., Johnson D.R. and Klaassen C.D., Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J. Pharmacol. Exp. Ther. 300: 97-104, 2002.
15. Slitt A.L., Cherrington N.J., Maher J.M. and Klaassen C.D., Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug Metab. Dispos. 31: 1176-1186, 2003.
16. Ogawa K., Suzuki H., Hirohashi T., Ishikawa T., Meier P.J., Hirose K., Akizawa T., Yoshioka M. and Sugiyama Y., Characterization of inducible nature of MRP3 in rat liver. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G438-46, 2000.
17. Hartmann G., Cheung A.K. and Piquette-Miller M., Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J. Pharmacol. Exp. Ther. 303: 273-81, 2002.
18. Cherrington N.J., Slitt A.L., Li N. and Klaassen C.D., Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metabo. Dispo. 32: 734-741, 2003.
19. Tzeng S.-J. and Huang J., Transcriptional regulation of the rat Mrp3 promoter in intestine cells. Biochem. Biophys. Res. Commun. 291: 270-277, 2002.
20. Hagen G., Dennig J., Priess A., Beato M. and Suske G., Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. J. Biol. Chem. 270: 24989-24994, 1995.
21. Kauffmann H.M. and Schrenk D., Sequence analysis and functional characterization of the 5′-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem. Biophys. Res. Commun. 245: 325-331, 1998.
22. Tanaka T., Uchiumi T., Hinoshita E., Inokuchi A., Toh S., Wada M., Takano H., Kohno K. and Kuwano M., The human multidrug resistance protein 2 gene: functional characterization of the 5′-flanking region and expression in hepatic cells. Hepatology 30: 1507-1512, 1999.
23. Takada T., Suzuki H. and Sugiyama Y., Characterization of 5′-flanking region of human MRP3. Biochem. Biophys. Res. Commun. 270: 728-732, 2000.
24. Kurz E.U., Cole S.P. and Deeley R.G., Identification of DNA-protein interactions in the 5′ flanking and 5′ untranslated regions of the human multidrug resistance protein (MRP1) gene: evaluation of a putative antioxidant response element/AP-1 binding site. Biochem. Biophys. Res. Commun. 285: 981-990, 2001.
25. Gidoni D., Kodanaka J.T., Barrere-Saldana H., Takajashi K., Chambon P. and Tjian R., Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. Science (Washington, DC) 230: 511-517, 1985.
26. Kuo C.F., Xanthopoulos K.G. and Darnell J.E., Fetal and adult localization of C/EBP: evidence for combinational action of transcription factors in cell-specific gene expression. Development 109: 473-481, 1990.
27. Lee Y.-H., Yano M., Liu S.-Y, Matsunaga E., Johnson P.F. and Gonzalez F.J., A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBPβ and a Sp1 factor. Mol. Cell Biol. 14: 1383-1394, 1994.
28. Lee Y.-H., Williams S.C., Baer M., Sterneck E., Gonzalez F.J. and Johnson P.F., The ability of C/EBPβ but not C/EBPα to synergize with an Sp1 protein is specified by the leucine zipper and activation domain. Mol. Cell Biol. 17: 2038-2047, 1997.
29. Liu Y.W., Tseng H.P., Chen L.C., Chen B.K. and Chang W.C., Functional cooperation of Simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophage. J. Immunol. 171: 821-828, 2003.
30. Kim S.J., Onwuta U.S., Lee Y.I., Li R., Botchan M.R. and Robbins P.D., The retinoblastoma gene product regulates Sp1-mediated transcription. Mol. Cell Biol. 12: 2455-2463, 1992.
31. Yang C.R., Wilson-Van Pattern C., Planchon S.M., Wuerzberger-Davis S.M., Davis T.W., Cuthill S., Miyamoto S. and Boothman D.A., Coordinate modulation of Sp1, NK-kB, and p53 in confluent human malignant melanoma cells after ionizing radiation. FASEB J. 14: 379 390, 2000.
32. Lee Y.I., Lee S., Lee Y., Bong Y.S., Hyun S.W., Yoo Y.D., Kim S.J., Kim Y.W. and Poo H.R., The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4. Oncogene 16: 2367-2380, 1998.
33. Mahoney C.W., Shuman J., McKnight S.L., Chen H. and Huang K., Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding. J. Biol. Chem. 267: 19396-19403, 1992.
34. Osada S., Yamamoto H., Nishihara T. and Imagawa M., DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family. J. Biol. Chem. 271: 3891-3896, 1996.
35. Bohan A., Chen W., Season L.A., Held M.A. and Boyer J.L., Tumor necrosis factor α-dependent up-regulation of Lrh-1 and Mrp3 (Abcc3) reduces liver injury in obstructive cholestasis. J. Biol. Chem. 278: 36688-36698, 2003.
36. Yin M., Yang S.Q., Lin H.Z., Lane M.D., Chatterjee S. and Diehl A.M., Tumor necrosis factor α promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. J. Biol. Chem. 271: 17974-17978, 1996.