GTP cyclohydrolase II structure and mechanism

Journal of Biological Chemistry

Volumn 280, Issue 44, 2005, Pages 36912-36919

  Ren, Jingshan ^a   Kotaka, Masayo ^a   Lockyer, Michael ^b   Lamb, Heather K ^c   Hawkins, Alastair R ^c   Stammers, David K ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Arrow Therapeutics   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; HYDROGEN BONDS; METABOLISM; MOLECULAR DYNAMICS; MOLECULES; PHOSPHATES;

GTP CYCLOHYDROLASE; RIBOFLAVIN BIOSYNTHESIS; RING-OPENING; ZINC ION;

ENZYMES;

2,5 DIAMINO 6 BETA RIBOSYL 4(3H) PYRIMIDINONE 5' PHOSPHATE; DIHYDRONEOPTERINE TRIPHOSPHATE; FOLIC ACID; FORMIC ACID; GUANINE; GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE II; GUANYLYL GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE II; PHOSPHONIC ACID DERIVATIVE; PYRIMIDINONE DERIVATIVE; RIBOFLAVIN; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BIOSYNTHESIS; COMPLEX FORMATION; COVALENT BOND; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; STRUCTURE ANALYSIS; VITAMIN METABOLISM;

BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GTP CYCLOHYDROLASE; GUANOSINE TRIPHOSPHATE; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; TYROSINE; ZINC;

EUKARYOTA;

EID: 27744517816     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M507725200     Document Type: Article

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