Biosynthesis of vitamin B2. An essential zinc ion at the catalytic site of GTP cyclohydrolase II

European Journal of Biochemistry

Volumn 269, Issue 21, 2002, Pages 5264-5270

  Kaiser, Johannes ^a   Schramek, Nicholas ^a   Eberhardt, Sabine ^a   Püttmer, Stefanie ^a   Schuster, Michael ^a   Bacher, Adelbert ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Formate; GTP cyclohydrolase; Imidazole ring; Pyrophosphate; Zinc ion

Indexed keywords

2 AMINO 5 FORMYLAMINO 6 RIBOSYLAMINO 4(3H) PYRIMIDINONE 5' TRIPHOSPHATE; 2,5 DIAMINO 6 RIBOSYLAMINO 4(3H) PYRIMIDONE 5' PHOSPHATE; CYANOCOBALAMIN; CYSTEINE; FORMIC ACID; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE II; GUANOSINE TRIPHOSPHATE DERIVATIVE; MUTANT PROTEIN; PROTEIN SUBUNIT; PYROPHOSPHATE; RIBOFLAVIN; SERINE; UNCLASSIFIED DRUG; ZINC ION; DEOXYGUANOSINE PHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; ZINC;

AMINO ACID SUBSTITUTION; ARTICLE; BIOSYNTHESIS; CATALYSIS; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; AMINO ACID SEQUENCE; CHEMISTRY; ENZYME ACTIVE SITE; ESCHERICHIA COLI; GENETICS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROPHOTOMETRY;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; DEOXYGUANINE NUCLEOTIDES; DIPHOSPHATES; ESCHERICHIA COLI; GTP CYCLOHYDROLASE; GUANOSINE TRIPHOSPHATE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RIBOFLAVIN; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 0036832419     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03239.x     Document Type: Article

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