Serum concentrations of 7α-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans

Hepatology

Volumn 24, Issue 1, 1996, Pages 123-126

  Sauter, Gerd ^a   Berr, Frieder ^a,b   Beuers, Ulrich ^a   Fischer, Sven ^a   Paumgartner, Gustav ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLEST 4 EN 3 ONE; 7 ALPHA HYDROXY 4 CHOLESTEN 3 ONE; 7 ALPHA-HYDROXY-4-CHOLESTEN-3-ONE; BILE ACID; BILIRUBIN; BIOLOGICAL MARKER; CARBON; DEUTERIUM;

ADULT; ARTICLE; BILE ACID SYNTHESIS; CHOLESTASIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GALLSTONE; GAS CHROMATOGRAPHY; HUMAN; ISOTOPE DILUTION ASSAY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; BILIARY CIRRHOSIS; BIOSYNTHESIS; BLOOD; BODY MASS; BODY WEIGHT; CHOLELITHIASIS; LIVER FUNCTION TEST; MASS FRAGMENTOGRAPHY; METABOLISM; MIDDLE AGED; PATHOLOGY; SCLEROSING CHOLANGITIS;

ADULT; BILE ACIDS AND SALTS; BILIRUBIN; BIOLOGICAL MARKERS; BODY MASS INDEX; BODY WEIGHT; CARBON ISOTOPES; CHOLANGITIS, SCLEROSING; CHOLELITHIASIS; CHOLESTASIS; CHOLESTENONES; DEUTERIUM; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LIVER CIRRHOSIS, BILIARY; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; RADIOISOTOPE DILUTION TECHNIQUE;

EID: 0029666109     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v24.pm0008707250     Document Type: Article

References (28)

1. Javitt NB. Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. FASEB J 1994;8:1308-1311.
2. Axelson M, Sjövall J. Potential bile acid precursors in plasma - possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man. J Steroid Biochem 1990;36:631-640.
3. Danielsson H, Einarsson K, Johansson G. Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurocholic acid. Eur J Biochem 1967;2:44-49.
4. Shefer S, Hauser S, Bekersky I, Mosbach EH. Biochemical site of regulation of bile acid biosynthesis in the rat. J Lipid Res 1970;11:404-411.
5. Ness GC, Pendleton LC, Li YC, Chiang JY. Effect of thyroid hormone on hepatic cholesterol 7α-hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats. Biochem Biophys Res Commun 1990; 172:1150-1156.
6. Davis RA, Highsmith WE, Malone-McNeal M, Archambault-Schexnayder J, Kuan J-C. Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids. J Biol Chem 1983;258:4079-4082.
7. Shefer S, Nguyen LB, Salen G, Ness GC, Chowdhary IR, Lerner S, Batta AK, et al. Differing effects of cholesterol and taurocholate on steady hepatic HMG-CoA reductase and cholesterol 7α-hydroxylase activities and mRNA levels in the rat. J Lipid Res 1992;33:1193-1199.
8. Heuman DM, Hylemon PB, Vlahcevic ZR. Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat. J Lipid Res 1989;30:1161-1171.
9. Chiang JY, Stroup D. Identification and characterization of a putative bile acid-responsive element in cholesterol 7α-hydroxylase gene promoter. J Biol Chem 1994;269:17502-17507.
10. Martin KO, Budai K, Javitt NB. Cholesterol and 27-hyroxycholesterol 7α-hydroxylation: evidence for two different enzymes. J Lipid Res 1993;34: 581-588.
11. 3H. J Clin Invest 1972;51:112-117.
12. Princen HMG, Meijer P, Wolthers BG, Vonk RJ, Kuipers F. Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis. Biochem J 1991;275:501-505.
13. Sauter G, Fischer S, Pahernik S, Koebe H-G, Paumgartner G. Formation of cholic acid and chenodeoxycholic acid from 7α-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. Biochim Biophys Acta 1996; 1300:25-29.
14. Oda H, Yamashita H, Kosahara K, Kuroki S, Nakamaya F. Esterified and total 7α-hydroxycholesterol in human plasma by gas chromatography-mass spectrometry as indices of cholesterol and bile acid biosynthesis. J Lipid Res 1990;31:2209-2218.
15. Yoshida T, Honda A, Tanaka N, Matsuzaki Y, He B, Osuga T. Simultaneous determination of mevalonate and 7α-hydroxycholesterol in human plasma by gas chromatography-mass spectrometry as indices of cholesterol and bile acid biosynthesis. J Chromatogr B Biomed Appl 1993;613: 185-193.
16. Hahn C, Reichel C, von Bergmann K. Serum concentration of 7α-hydroxycholesterol as an indicator of bile acid synthesis in humans. J Lipid Res 1995;36:2059-2066.
17. Okamoto S, Fukushima K, Higashijima H, Makino I, Kishinaka M, Oda H, Yamashita H, et al. Serum 7α-hydroxycholesterol reflects hepatic bile acid synthesis in patients with obstructive jaundice after external biliary drainage. HEPATOLOGY 1994;20:95-100.
18. Axelson M, Aly A, Sjövall J. Level of 7α-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis. FEBS Lett 1988;239:324-328.
19. Eusufzai S, Axelson M, Angelin B, Einarsson K. Serum 7α-hydroxy-4-cholesten-3-one concentrations in the evaluation of bile acid malabsorption in patients with diarrhea: correlation to SeHCAT test. Gut 1993;34:698-701.
20. Axelson M, Björkhem I, Reihnér E, Einarsson K. The plasma level of 7α-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7α-hydroxylase in man. FEBS Lett 1991;284:216-218.
21. Yoshida T, Honda A, Tanaka N, Matsuzaki Y, Shoda J, He B, Osuga T, et al. Determination of 7α-hydroxy-4-cholesten-3-one level in plasma using isotope-dilution mass spectrometry and monitoring its circadian rhythm in humans as an index of bile acid biosynthesis. J Chromatogr 1994;655: 179-187.
22. 13C-labeled bile acids. J Lipid Res 1984;25:1313-1319.
23. Setchell KDR, Matsui A. Serum bile acid analysis. Clin Chim Acta 1982; 127:1-17.
24. Swell L, Gustafsson J, Schwartz CC, Halloran LG, Danielsson H, Vlahcevic ZR. An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man. J Lipid Res 1980;21:455-466.
25. Hofmann AF, Hoffman NE. Measurement of bile acid kinetics by isotope dilution in man. Gastroenterology 1974;67:314-323.
26. Macdonald I, Bokkenheuser VD, Winter J, McLernon AM, Mosbach EH. Degradation of steroids in the human gut. J Lipid Res 1983;23:675.
27. Hylemon PB. Metabolism of bile acids in the intestinal microflora. In: Danielsson H, Sjövall J, eds. Sterols and bile acids. Amsterdam: Elsevier, 1985:331-343.
28. Hylemon PB. Biochemistry and genetics of intestinal bile salt metabolism. In: Paumgartner G, Stiehl A, Gerok W, eds. Bile acids as therapeutic agents. From basic science to clinical practice. Dordrecht, Boston, London: Kluwer Academic Publishers, 1991:1-11.