Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: Role of Akt phosphorylation, PTB1B, PPARγ and c-Jun

Diabetologia

Volumn 48, Issue 11, 2005, Pages 2412-2421

  Fang, C X ^a   Dong, F ^a   Ren, B H ^a   Epstein, P N ^b   Ren, J ^a  

^a UNIVERSITY OF WYOMING   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Antioxidant; Insulin resistance; Intracellular Ca2+ transients; Myocyte; Shortening

Indexed keywords

ANTIOXIDANT; FURA 2; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; METALLOTHIONEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; STARCH; STRESS ACTIVATED PROTEIN KINASE; SUCROSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BODY WEIGHT; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME PHOSPHORYLATION; FEEDING BEHAVIOR; FLUORESCENCE; GLUCOSE INTOLERANCE; HEART CONTRACTION; HEART DISEASE; HEART MUSCLE CELL; HEART VENTRICLE; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; INSULIN; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; METALLOTHIONEIN; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; ONCOGENE PROTEIN V-AKT; OXIDATIVE STRESS; PHOSPHORYLATION; PPAR GAMMA; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 27744463211     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1940-y     Document Type: Article

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