Soluble amyloid β-protein is increased in frontotemporal dementia with tau gene mutations

Journal of Alzheimer's Disease

Volumn 6, Issue 1, 2004, Pages 45-51

  Vitali, Antonella ^a   Piccini, Alessandra ^a   Borghi, Roberta ^a   Fornaro, Pantaleo ^a   Siedlak, Sandra L ^b   Smith, Mark A ^b   Gambetti, Pierluigi ^b   Ghetti, Bernardino ^c   Tabaton, Massimo ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid protein; FTDP 17; Tau pathology; Tau protein

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PYRAMIDAL NERVE CELL;

EID: 1842532341     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2004-6106     Document Type: Article

References (29)

1. D.R. Borchelt, G. Thinakaran, C.B. Eckman, M.K. Lee, F. Davenport, T. Ratovitsky, C.M. Prada, G. Kim, S. Seekins, D. Yager, H.H. Slunt, R. Wang, M. Seeger, A.I. Levey, S.E. Gandy, N.G. Copeland, N.A. Jenkins, D.L. Price, S.G. Younkin and S.S. Sisodia, Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo, Neuron 17 (1996), 1005-1013.
2. M. Citron, D. Westaway, W. Xia, G. Carlson, T. Diehl, G. Levesque, K. Johnson-Wood, M. Lee, P. Seubert, A. Davis, D. Kholodenko, R. Motter, R. Sherrington, B. Perry, H. Yao, R. Strome, I. Lieberburg, J. Rommens, S. Kim, D. Schenk, P. Fraser, P. St George Hyslop and D.J. Selkoe, Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice, Nat. Med. 3 (1997), 67-72.
3. D.R. Davis, B.H. Anderton, J.P. Brion, C.H. Reynolds and D.P. Hanger, Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures, J. Neurochem. 68 (1997), 1590-1597.
4. I. D'Souza, P. Poorkaj, M. Hong, D. Nochlin, V.M. Lee, T.D. Bird and G.D. Schellenberg, Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements, Proc. Natl. Acad. Sci. USA 96 (1999), 5598-603.
5. K. Duff, C. Eckman, C. Zehr, X. Yu, C.M. Prada, J. Pereztur, M. Hutton, L. Buee, Y. Harigaya, D. Yager, D. Morgan, M.N. Gordon, L. Holcomb, L. Refolo, B. Zenk, J. Hardy and S. Younkin, Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1, Nature 383 (1996), 710-713.
6. G. Giaccone, F. Tagliavini, G. Linoli, C. Bouras, L. Frigerio, B. Frangione and O. Bugiani, Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques, Neurosci. Lett. 97 (1989), 232-238.
7. C. Geula, C.K. Wu, D. Saroff, A. Lorenzo, M. Yuan and B.A. Yankner, Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity, Nat. Med. 4 (1998), 827-831.
8. M. Goedert, M.G. Spillantini, R.A. Crowther, S.G. Chen, P. Parchi, M. Tabaton, D.J. Lanska, W.R. Markesbery, K.C. Wilhelmsen, D.W. Dickson, R.B. Petersen and P. Gambetti, Tau gene mutation in familial progressive subcortical gliosis, Nat. Med. 5 (1999), 454-457.
9. J. Gotz, F. Chen, J. van Dorpe and R.M. Nitsch, Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils, Science 293 (2001), 1491-1495.
10. J. Hardy and D.J. Selkoe, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science 297 (2002), 353-356.
11. D.S. Knopman, A.R. Mastri, W.H. 2nd Frey, J.H. Sung and T. Rustan, Dementia lacking distinctive histologic features: a common non-Alzheimer degenerative dementia, Neurology 40 (1990), 251-256.
12. K. Islam and E. Levy, Carboxyl-terminal fragments of beta-amyloid precursor protein bind to microtubules and the associated protein tau, Am. J. Pathol. 151 (1997), 265-271.
13. V.M. Lee, M. Goedert and J.Q. Trojanowski, Neurodegenerative tauopathies, Annu. Rev. Neurosci. 24 (2001), 1121-1159.
14. C.A. Lemere, J.K. Blusztajn, H. Yamaguchi, T. Wisniewski, T.C. Saido and D.J. Selkoe, Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation, Neurobiol. Dis. 3 (1996), 16-32.
15. J. Lewis, D.W. Dickson, W.L. Lin, L. Chisholm, A. Corral, G. Jones, S.H. Yen, N. Sahara, L. Skipper, D. Yager, C. Eckman, J. Hardy, M. Hutton and E. McGowan, Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP, Science 293 (2001), 1487-1491.
16. M.P. Mattson, B. Cheng, D. Davis, K. Bryant, I. Lieberburg and R.E. Rydel, beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity, J. Neurosci. 12 (1992), 376-389.
17. S.S. Mirra, J.R. Murrell, M. Gearing, M.G. Spillantini, M. Goedert, R.A. Crowther, A.I. Levey, R. Jones, J. Green, J.M. Shoffner, B.H. Wainer, M.L. Schmidt, J.Q. Trojanowski and B. Ghetti, Tau pathology in a family with dementia and a P301L mutation in tau, J. Neuropathol. Exp. Neurol. 58 (1999), 335-345.
18. S.M. Rosso, W. Kamphorst, R. Ravid and J.C. van Swieten, Coexistent tau and amyloid pathology in hereditary frontotemporal dementia with tau mutations, Ann. N. Y. Acad. Sci. 920 (2000), 115-119.
19. C. Russo, T.C. Saido, L.M. DeBusk, M. Tabaton, P. Gambetti and J.K. Teller, Heterogeneity of water-soluble amyloid β-peptide in Alzheimer's disease and Down's syndrome brains, FEBS Lett 409 (1997), 411-416.
20. Y. Saito, K. Suzuki, E. Nanba, T. Yamamoto, K. Ohno and S. Murayama, Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity, Ann. Neurol. 52 (2002), 351-355.
21. D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T.D. Bird, J. Hardy, M. Hutton, W. Kukull, E. Larson, E. Levy-Lahad, M. Viitanen, E. Peskind, P. Poorkaj, G. Schellenberg, R. Tanzi, W. Wasco, L. Lannfelt, D.J. Selkoe and S. Younkin, Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease, Nat. Med. 2 (1996), 864-870.
22. D.J. Selkoe, T. Yamazaki, M. Citron, M.B. Podlisny, E.H. Koo, D.B. Teplow and C. Haass, The role of APP processing and trafficking pathways in the formation of amyloid beta-protein, Ann. N. Y. Acad. Sci. 777 (1996), 57-64.
23. R.W. Shin, G.T. Bramblett, V.M. Lee and J.Q. Trojanowski, Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin, Proc. Natl. Acad. Sci. USA 90 (1993), 6825-6628.
24. M.A. Smith, S.L. Siedlak, P.L. Richey, P. Mulvihill, J. Ghiso, B. Frangione, F. Tagliavini, G. Giaccone, O. Bugiani, D. Prapromik, et al., Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease, Nat. Med. 1 (1995), 365-369.
25. M.G. Spillantini, R.A. Crowther, W. Kamphorst, P. Heutink and van J.C. Swieten, Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau, Am. J. Pathol. 153 (1998), 1359-1363.
26. K. Stamer, R. Vogel, E. Thies, E. Mandelkow and E.M. Mandelkow, Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress, J. Cell. Biol. 156 (2002), 1051-1063.
27. M. Tabaton, S. Cammarata, G. Mancardi, V. Manetto, L. Autilio-Gambetti, G. Perry and P. Gambetti, Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles, Proc. Natl. Acad. Sci. USA 88 (1991), 2098-2102.
28. J.K. Teller, C. Russo, L.M. DeBusk, G. Angelini, D. Zaccheo, F. Dagna-Bricarelli, P. Scartezzini, S. Bertolini, D.M. Mann, M. Tabaton and P. Gambetti, Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome, Nat. Med. 2 (1996), 93-95.
29. S.A. Waschuk, E.A. Elton, A.A. Darabie, P.E. Fraser and J.A. McLaurin, Cellular membrane composition defines A beta-lipid interactions, J. Biol. Chem. 276 (2001), 33561-33568.