Proteasome inhibition induces selective motor neuron death in organotypic slice cultures

Journal of Neuroscience Research

Volumn 82, Issue 4, 2005, Pages 443-451

  Tsuji, Sachiko ^a   Kikuchi, Seiji ^a   Shinpo, Kazuyoshi ^b   Tashiro, Jun ^a   Kishimoto, Riichiro ^a   Yabe, Ichiro ^a   Yamagishi, Shoichi ^c   Takeuchi, Masayoshi ^d   Sasaki, Hidenao ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Nishimaruyama Hospital   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d HOKURIKU UNIVERSITY   (Japan)

Author keywords

Amyotrophic lateral sclerosis; Calcium; Motor neuron; Proteasome

Indexed keywords

BUFFER; CALCIUM BINDING PROTEIN; CALCIUM CHELATING AGENT; CALCIUM ION; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; LACTACYSTIN; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FOLLOW UP; INTRACELLULAR SPACE; NERVE CELL DEGENERATION; NERVE CELL LESION; NERVE CELL NECROSIS; NEURITE; NEUROFILAMENT; NEUROTOXICITY; NEWBORN; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SPINAL CORD MOTONEURON; TISSUE CULTURE;

ACETYLCYSTEINE; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; CELL COUNT; CELL DEATH; CELL SURVIVAL; CHELATING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EGTAZIC ACID; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MOTOR NEURONS; NEURITES; NEUROFILAMENT PROTEINS; ORGAN CULTURE TECHNIQUES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TIME FACTORS;

EID: 27644594653     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20665     Document Type: Article

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