Combined treatment potentiates the developmental toxicity of ibuprofen and acetazolamide in rats

Drug and Chemical Toxicology

Volumn 28, Issue 4, 2005, Pages 409-421

  Cappon, Gregg D ^a,b   Fleeman, T L ^a   Cook, J C ^a   Hurtt, M E ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

Author keywords

Acetazolamide; Ibuprofen teratology; Rat

Indexed keywords

ACETAZOLAMIDE; ACETYLSALICYLIC ACID; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; DIAPHRAGM HERNIA; DRUG POTENTIATION; FEMALE; FETOTOXICITY; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; HEART VENTRICLE SEPTUM DEFECT; NONHUMAN; PREGNANCY; PRENATAL DRUG EXPOSURE; RAT; SKELETON MALFORMATION; TERATOGENESIS;

ABNORMALITIES, DRUG-INDUCED; ACETAZOLAMIDE; ANIMALS; ANIMALS, NEWBORN; BIRTH WEIGHT; BODY WEIGHT; CARBONIC ANHYDRASE INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG SYNERGISM; EATING; FEMALE; FETAL DEVELOPMENT; HEART SEPTAL DEFECTS, VENTRICULAR; HERNIA, DIAPHRAGMATIC; IBUPROFEN; MALE; MATERNAL EXPOSURE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 27644588511     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540500262805     Document Type: Article

References (35)

1. Ariyuki, F. (1987). Growth retardation induced in rat fetuses by maternal fasting and massive doses of ergocalciferol. J. Nutr. 117:2915-2923.
2. Bird, I. M., Zhang, L., Magness, R. R. (2003). Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284(2):R245-R258.
3. Boura, A. L., Walters, W. A., Read, M. A., Leitch, I. M. (1994). Autacoids and control of human placental blood flow. Clin. Exp. Pharmacol. Physiol. 21(10): 737-748.
4. Cappon, G. D., Cook, J. C., Hurtt, M. E. (2003). The relationship between cyclooxygenase (COX) 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res., B 68:47-56.
5. Chahoud, I., Ligensa, A., Dietzel, L., Faqi, A. S. (1999). Correlation between maternal toxicity and embryo/fetal effects. Reprod. Toxicol. 13(5):375-381.
6. Cook, J. C., Jacobson, C. F., Gao, F., Tassinari, M. S., Hurtt, M. E., DeSesso, J. M. (2002). Analysis of nonsteroidal anti-inflammatory drug (NSAID) literature for potential developmental toxicity in rats and rabbits. Birth Defects Res., B 68:5-26.
7. De-Carvalho, R. R., Delgado, I. F., Souza, C. A. M., Chahoud, I., Paumgartten, F. J. R. (1994). Embryotoxicity of methanol in well-nourished and malnourished rats. Braz. J. Med. Biol. Res. 27:2915-2923.
8. DeSesso, J. M. (1997). Comparative embryology. In: Hood, R. D., ed. Handbook of Developmental Toxicology. New York: CRC Press, pp. 111-174.
9. Gant, N. F., Whalley, P. J., Everett, R. B., Worley, R. J., MacDonald, P. C. (1987). Control of vascular reactivity in pregnancy. Am. J. Kidney Dis. 9(4):303-307.
10. Gupta, U., Cook, J. C., Tassinari, M. S., Hurtt, M. E. (2003). Comparison of developmental toxicology of aspirin (ASA) in rats using selected dosing paradigms. Birth Defects Res., B 68:27-37.
11. Habermehl, D. A., Janowiak, M. A., Vagnoni, K. E., Bird, I. M., Magness, R. R. (2000). Endothelial vasodilator production by uterine and systemic arteries. IV. Cyclooxygenase isoform expression during the ovarian cycle and pregnancy in sheep. Biol. Reprod. 62(3):781-788.
12. Hannah, R. S., Moore, K. L. (1971). Effects of fasting and insulin on skeletal development in rats. Teratology 4:135-140.
13. Kavlock, R. J., Logsdon, T., Gray, J. A. (1993). Fetal development in the rat following disruption of maternal renal function during pregnancy. Teratology 48(3):247-258.
14. Khera, K. S. (1985). Maternal toxicity: a possible etiological factor in embryo-fetal deaths and malformations of rodent-rabbit species. Teratology 31:129-153.
15. Kimmel, C. A., Wilson, J. G., Schumacher, H. J. (1971). Studies on metabolism and identification of the causative agent in aspirin teratogenesis in rats. Teratology 4(1):15-24.
16. Kimura, T., Yoshida, Y., Toda, N. (1992). Mechanisms of relaxation induced by prostaglandins in isolated canine uterine arteries. Am. J. Obstet. Gynecol. 167(5):1409-1416.
17. Kivilaakso, E. (1982). Inhibition of gastric mucosal carbonic anhydrase by taurocholic acid and other ulcerogenic agents. Am. J. Surg. 144(5):554-557.
18. Kuhn, D. C., Stuart, M. J. (1987). Cyclooxygenase inhibition reduces placental transfer: reversal by carbacyclin. Am. J. Obstet. Gynecol. 157(1):194-198.
19. Maren, T. H. (1965). Forelimb deformity in rats: association with acetazolamide. Science 150(692):79.
20. Maren, T. H., Wynns, G. C., Wistrand, P. J. (1993). Chemical properties of carbonic anhydrase IV, the membrane-bound enzyme. Mol. Pharmacol. 44(4): 901-905.
21. Matsumoto, T., Kanamaru, K., Sugiyama, Y., Murata, Y. (1992). Endothelium-derived relaxation of the pregnant and nonpregnant canine uterine artery. J. Reprod. Med. 37(6):529-533.
22. Ritter, E. J., Scott, W. J., Wilson, J. G., Mathinos, P. R., Randall, J. L. (1982). Potentiative interactions between caffeine and various teratogenic agents. Teratology 25(1):95-100.
23. Schardein, J. L. (1987). Approaches to defining the relationship of maternal and developmental toxicity. Teratog. Carcinog. Mutagen. 7:255-272.
24. Scott, W. J. Jr. (1970). Effects of intrauterine administration of acetazolamide in rats. Teratology 3(3):261-267.
25. Scott, W. J., Hirsch, K. S., DeSesso, J. M., Wilson, J. G. (1981). Comparative studies on acetazolamide teratogenesis in pregnant rats, rabbits, and rhesus monkeys. Teratology 24(1):37-42.
26. Solomon, H. M., Wier, P. J., Fish, C. J., Hart, T. K., Johnson, C. M., Posobiec, L. M., Gowan, C. C., Maleeff, B. E., Kerns, W. D. (1997). Spontaneous and induced alterations in the cardiac membranous ventricular septum of fetal, weanling, and adult rats. Teratology 55:185-194.
27. Streck, R. A., Kumpf, S. W., Ozolins, T. R., Stedman, D. B. (2002). Rat embryos express transcripts fo cyclooxygenase-1 and carbonic anhydrase-4, but not cyclooxygenase-2, during organogenesis. Birth Defects Res., B 68:57-69.
28. Stuckhardt, J. L., Poppe, S. M. (1984). Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing. Teratog. Carcinog. Mutagen. 4:181-188.
29. Ugen, K. E., Scott, W. J. Jr. (1985). Potentiation of acetazolamide induced ectrodactyly in Wistar rats by vasoactive agents and physical clamping of the uterus. Teratology 31(2):273-278.
30. Ugen, K. E., Scott, W. J. Jr. (1986). Acetazolamide teratogenesis in Wistar rats: potentiation and antagonism by adrenergic agents. Teratology 34(2):195-200.
31. Ugen, K. E., Scott, W. J. Jr. (1987). Reduction of uterine blood flow by phenylephrine, an alpha-adrenergic agonist, in the day 11 pregnant rat: relationship to potentiation of acetazolamide teratogenesis. Teratology 36(1):133-141.
32. Vane, J. R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat., New Biol. 231(25):232-235.
33. Vane, J. R., Bakhle, Y. S., Botting, R. M. (1998). Cyclooxygenases 1 and 2. Annu. Rev. Pharmacol. Toxicol. 38:97-120.
34. Wilson, J. G., Maren, T. H., Takano, K., Ellison, A. (1968). Teratogenic action of carbonic anhydrase inhibitors in the rat. Teratology 1(1):51-60.
35. Wise, L. D., Beck, S. L., Beltrame, D., Beyer, B., Chahoud, I., Clark, R. L., Clark, R., Druga, A. M., Feuston, M. E., Guittin, P., Henwood, S. M., Kimmel, C. A., Lindstorm, P., Palmer, A. K., Petrere, J. A., Solomon, H. M., Yasuda, M., York, R. G. (1997). Terminology of developmental anomalies in common laboratory mammals (version 1). Teratology 55:249-292.