Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling

Molecular Endocrinology

Volumn 19, Issue 11, 2005, Pages 2859-2870

  Gyun, Jee Song ^a   Hinkle, Patricia M ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AP 20187; BETA ARRESTIN; FK 506 BINDING PROTEIN; HYBRID PROTEIN; INOSITOL PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOMER; PROTIRELIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL TRANSPORT; CONTROLLED STUDY; DIMERIZATION; EMBRYO; ENZYME ACTIVATION; FEMALE; HORMONE BINDING; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; MOUSE; NONHUMAN; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; ARRESTINS; CALCIUM; CELL MEMBRANE; CHO CELLS; CRICETINAE; DIMERIZATION; ENZYME ACTIVATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C; PROTEIN TRANSPORT; RECEPTORS, THYROTROPIN-RELEASING HORMONE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TACROLIMUS; TACROLIMUS BINDING PROTEINS; THYROTROPIN-RELEASING HORMONE;

ANIMALIA;

EID: 27644578567     PISSN: 08888809     EISSN: 08888809     Source Type: Journal    
DOI: 10.1210/me.2005-0133     Document Type: Article

References (44)

1. Hinkle PM, Nelson EJ, Ashworth R 1996 Characterization of the calcium response to TRH in lactotrophs and GH-cells. Trends Endocrinol Metab 7:370-374
2. Ohmichi M, Sawada T, Kanda Y, Koike K, Hirota K, Miyake A, Saltiel AR 1994 Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation. J Biol Chem 269:3783-3788
3. Smith J, Yu R, Hinkle PM 2001 Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with β-arrestin or receptor endocytosis. Mol Endocrinol 15:1539-1548
4. Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, Eidne KA 2001 Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer. J Biol Chem 276:12736-12743
5. Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA 2002 Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of β-arrestins 1 and 2. J Biol Chem 277:50422-50430
6. Zhu CC, Cook LB, Hinkle PM 2002 Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. J Biol Chem 277:28228-28237
7. Breitwieser GE 2004 G protein-coupled receptor oligomerization: implications for G protein activation and cell signaling. Circ Res 94:17-27
8. Kroeger KM, Pfleger KD, Eidne KA 2003 G-protein coupled receptor oligomerization in neuroendocrine pathways. Front Neuroendocrinol 24:254-278
9. Terrillon S, Bouvier M 2004 Roles of G-protein-coupled receptor dimerization. EMBO Rep 5:30-34
10. Overton MC, Blumer KJ 2000 G-protein-coupled receptors function as oligomers in vivo. Curr Biol 10:341-344
11. Maggio R, Vogel Z, Wess J 1993 Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors. Proc Natl Acad Sci USA 90:3103-3107
12. Margeta-Mitrovic M, Jan YN, Jan LY 2000 A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 27:97-106
13. Hebert TE, Loisel TP, Adam L, Ethier N, Onge SS, Bouvier M 1998 Functional rescue of a constitutively desensitized β2AR through receptor dimerization. Biochem J 330(Pt 1):287-293
14. Lee SP, O'Dowd BF, Ng GY, Varghese G, Akil H, Mansour A, Nguyen T, George SR 2000 Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell. Mol Pharmacol 58:120-128
15. Cvejic S, Devi LA 1997 Dimerization of the δ opioid receptor: implication for a role in receptor internalization. J Biol Chem 272:26959-26964
16. Rodriguez-Frade JM, Vila-Coro AJ, de Ana AM, Albar JP, Martinez AC, Mellado M 1999 The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2. Proc Natl Acad Sci USA 96:3628-3633
17. Stanasila L, Perez JB, Vogel H, Cotecchia S 2003 Oligomerization of the α1a- and α1b-adrenergic receptor subtypes. Potential implications in receptor internalization. J Biol Chem 278:40239-40251
18. Overton MC, Blumer KJ 2002 The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J Biol Chem 277:41463-41472
19. Latif R, Graves P, Davies TF 2002 Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor. J Biol Chem 277:45059-45067
20. Terrillon S, Durroux T, Mouillac B, Breit A, Ayoub MA, Taulan M, Jockers R, Barberis C, Bouvier M 2003 Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis. Mol Endocrinol 17:677-691
21. Angers S, Salahpour A, Joly E, Hilairet S, Chelsky D, Dennis M, Bouvier M 2000 Detection of β2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci USA 97:3684-3689
22. Clackson T, Yang W, Rozamus LW, Hatada M, Amara JF, Rollins CT, Stevenson LF, Magari SR, Wood SA, Courage NL, Lu X, Cerasoli Jr F, Gilman M, Holt DA 1998 Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci USA 95:10437-10442
23. Varnai P, Rother KI, Balla T 1999 Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. J Biol Chem 274:10983-10989
24. Oakley RH, Laporte SA, Holt JA, Barak LS, Caron MG 1999 Association of β-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. J Biol Chem 274:32248-32257
25. Innamorati G, Le Gouill C, Balamotis M, Birnbaumer M 2001 The long and the short cycle. Alternative intracellular routes for trafficking of G-protein-coupled receptors. J Biol Chem 276:13096-13103
26. Yu R, Hinkle PM 1999 Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11. J Biol Chem 274:15745-15750
27. Perron A, Chen ZG, Gingras D, Dupre DJ, Stankova J, Rola-Pleszczynski M 2003 Agonist-independent desensitization and internalization of the human platelet-activating factor receptor by coumermycin-gyrase B-induced dimerization. J Biol Chem 278:27956-27965
28. Groarke DA, Drmota T, Bahia DS, Evans NA, Wilson S, Milligan G 2001 Analysis of the C-terminal tail of the rat thyrotropin-releasing hormone receptor-1 in interactions and cointernalization with β-arrestin 1-green fluorescent protein. Mol Pharmacol 59:375-385
29. Yu R, Hinkle PM 1998 Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization. Mol Endocrinol 12:737-749
30. Gage RM, Kim KA, Cao TT, von Zastrow M 2001 A transplantable sorting signal that is sufficient to mediate rapid recycling of G protein-coupled receptors. J Biol Chem 276:44712-44720
31. Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M 1999 A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor. Nature 401:286-290
32. Volpicelli LA, Lah JJ, Fang G, Goldenring JR, Levey AI 2002 Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. J Neurosci 22:9776-9784
33. Lapierre LA, Kumar R, Hales CM, Navarre J, Bhartur SG, Burnette JO, Provance Hr DW, Mercer JA, Bahler M, Goldenring JR 2001 Myosin vb is associated with plasma membrane recycling systems. Mol Biol Cell 12:1843-1857
34. Yang J, Symes K, Mercola M, Schreiber SL 1998 Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. Curr Biol 8:11-18
35. Muthuswamy SK, Gilman M, Brugge JS 1999 Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol 19:6845-6857
36. Welm BE, Freeman KW, Chen M, Contreras A, Spencer DM, Rosen JM 2002 Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland. J Cell Biol 157:703-714
37. Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR 1993 Controlling signal transduction with synthetic ligands. Science 262:1019-1024
38. Blau CA, Peterson KR, Drachman JG, Spencer DM 1997 A proliferation switch for genetically modified cells. Proc Natl Acad Sci USA 94:3076-3081
39. Spencer DM, Belshaw PJ, Chen L, Ho SN, Randazzo F, Crabtree GR, Schreiber SL 1996 Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. Curr Biol 6:839-847
40. Kohout TA, Lin FS, Perry SJ, Conner DA, Lefkowitz RJ 2001 β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci USA 98:1601-1606
41. Ashworth R, Hinkle PM 1996 Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs. Endocrinology 137:5205-5212
42. Hinkle PM, Puskas JA 2004 Detection of G protein-coupled receptors by immunofluorescence microscopy. Methods Mol Biol 237:127-134
43. Cook LB, Hinkle PM 2004 Agonist-dependent upregulation of thyrotrophin-releasing hormone receptor protein. Biochem J 380:815-821
44. Hinkle PM, Tashjian Jr AH 1973 Receptors for thyrotropin-releasing hormone in prolactin producing rat pituitary cells in culture. J Biol Chem 248:6180-6186