Copper alters the conformation and transcriptional activity of the tumor suppressor protein p53 in human Hep G2 cells

Experimental Biology and Medicine

Volumn 230, Issue 10, 2005, Pages 699-708

  Tassabehji, Nadine M ^a   VanLandingham, Jacob W ^a   Levenson, Cathy W ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Cu; Liver; Oxidation; Wilson disease

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; COPPER; GLUTATHIONE PEROXIDASE; LUCIFERASE; PROTEIN FOS; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; BIOTINYLATION; CANCER INHIBITION; CELL STRAIN HEPG2; CONFORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; ENZYME REGULATION; GENE CONTROL; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MUTANT; OXIDATIVE STRESS; PROTEIN SYNTHESIS; TRANSCRIPTION INITIATION;

EID: 27644573557     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/153537020523001002     Document Type: Article

References (50)

1. Schwartz D, Rotter V. p53-dependent cell cycle control: response to genotoxic stress. Semin Cancer Biol 8:325-336. 1988.
2. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:855-878, 1994
3. Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, Glover T, Collins FS, Weston A, Modali R, Harris CC, Vogelstein B. Mutations in the p53 gene occur in diverse human tumor types. Nature 342:705-708, 1989.
4. Lee JK, Kim JH, Nam KT, Lee SH. Molecular events associated with apoptosis and proliferation induced by ultraviolet-B radiation in the skin of hairless mice. J Dermatol Sci 32:171-179, 2003.
5. Macip S, Igarashi M, Berggren P, Yu J, Lee SW. Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol 23:8576-8585, 2003.
6. Libonati JP, Fitch CA, Rutkoski NJ, Levenson CW. Zinc regulation of cobalt-induced apoptosis in cultured human neurons. Nutr Neurosci 3:425-433, 2000.
7. VanLandingham JW, Fitch CA, Levenson CW. Zinc inhibits the nuclear translocation of the tumor suppressor protein p53 and protects cultured human neurons from copper induced neurotoxicity. Neuro-Molec Med 1:171-182, 2002.
8. Hartwig A, Asmuss M, Blessing H, Hoffmann S, Jahnke G, Khandelwal S, Pelzer A, Burkle A. Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability. Food Chem Toxicol 40:1179-1184, 2002.
9. Bilim VN, Tomita Y, Kawasaki T, Takeda M, Takahashi K. Adriamycin (ADM) induced apoptosis in transitional cell cancer (TCC) cell lines accompanied by p21 WAF1/CIP1 induction. Apoptosis 2:207-213, 1997.
10. Narayanan VS, Fitch CA, Levenson CW. Tumor suppressor protein p53 mRNA and sub-cellular localization are altered by changes in cellular copper in human HepG2 cells. J Nutr 131:1427-1432, 2001.
11. Strand S, Hofmann WJ, Grambihler A, Hug H, Volkmann M, Otto G, Wesch H, Mariani S, Hack V, Stremmel W, Krammer PH, Galle PH. Hepatic failure and liver damage in acute Wilson's disease involve CD95 (APO-1/Fas) mediated apoptosis. Nat Med 4:588-593, 1998.
12. Preston BL, Shackelford J. Risk-based analysis of environmental monitoring data: application to heavy metals in North Carolina surface waters. Environ Manag 30:279-293, 2002.
13. Yang XE, Long XX, Ni WZ, Ye ZQ, He ZL, Stoffella PJ, Calvert DV. Assessing copper thresholds for phytotoxicity and potential dietary toxicity in selected vegetable crops. J Environ Sci Health Bull 37:625-635, 2002.
14. Muller T, Langner C, Fuchsbichler A, Heinz-Erian P, Ellemunter H, Schlenck B, Bavdekar AR, Pradhan AM, Pandit A, Muller-Hocker J, Melter M, Kobayashi K, Nagasaka H, Kikuta H, Muller W, Tanner MS, Sternlieb I, Zatloukal K, Denk H. Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis. Hepatology 39:963-969, 2004.
15. Shah AB, Chernov I, Zhang HT, Ross BM, Das K, Lutsenko S, Parano E, Pavone L, Evgrafov O, Ivanova-Smolenskaya IA, Anneren G, Westermark K, Urrutia FH, Penchaszadeh GK, Sternlieb I, Scheinberg IH, Gilliam TC, Petrukhin K. Identification and analysis of mutations in the Wilson disease gene (ATP7B): population frequencies, genotypephenotype correlation, and functional analyses. Am J Hum Genet 61:317-328, 1997.
16. Harada M, Sakisaka S, Terada K, Kimura R, Kawaguchi T, Koga H, Taniguchi E, Sasatomi K, Miura N, Suganuma T, Fujita H, Furuta K, Tanikawa K, Sugiyama T, Sata M. Role of ATP7B in biliary copper excretion in a human hepatoma cell line and normal rat hepatocytes. Gastroenterology 118:921-928, 2000.
17. Walshe JM, Waldenstrom E, Sams V, Nordlinder H, Westermark. Abdominal malignancies in patients with Wilson's disease. QJM 96:657-662, 2003.
18. Hussain SP, Raja K, Amstad PA, Sawyer M, Trudel LJ, Wogan GN, Hofseth LJ, Shields PG, Billiar TR, Trautwein C, Hohler T, Galle PR, Phillips DH, Markin R, Marrogi AJ, Harris CC. Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. Proc Natl Acad Sci U S A 97:12770-12775, 2000.
19. Tkeshelashvili LK, McBride T, Spence K, Loeb LA. Mutation spectrum of copper-induced DNA damage. J Biol Chem 266:6401-6406, 1991.
20. Sagripanti J, Goering PL, Lamanna A. Interaction of copper with DNA and antagonismby other metals. Toxicol Appl Pharm 110:477-485, 1991.
21. Jia L, Wang XX, Harris CC. Hepatitis B virus X protein inhibits nucleotide excision repair. Internatl J Cancer 80:875-879, 1999.
22. Hainaut P, Rolley N, Davies M, Milner J. Modulations of copper of p53 conformation and sequence-specific DNA binding: role of Cu (II)/ Cu (I) redox mechanisms. Oncogene 10:27-32, 1995.
23. Choudhury S, Zhang R, Frenkel K, Kawamori T, Chung FL, Roy R. Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats. Cancer Res 63:7704-7707, 2003.
24. Frank N, Knauft J, Amelung F, Nair J, Wesch H, Bartsch H. No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases. Mutat Res 523/524:127-135, 2003.
25. Aden DP, Fogel A, Plotkin S, Damjanov I, Knowles BB. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 286:615-616, 1979.
26. Levenson CW, Shay NF, Cousins RJ. Cloning and initial characterization of the promoter region of the rat cysteine-rich intestinal protein gene. Biochem J 303:731-736, 1994.
27. Kelavkar UP, Cohen C, Kamitani H, Eling TE, Badr KF. Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging. Carcinogenesis 21:1777-1787, 2000.
28. Shureiqi I, Chen D, Lee JJ, Yang P, Newman RA, Brenner DE, Lotan R, Fischer SM, Lippman SM. J. 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. Natl Cancer Inst 92:1136-1142, 2000.
29. Zitterbart K, Veselska R. Effect of retinoic acid on the actin cytoskeleton in HL-60 cells. Neoplasma 48:456-461, 2001.
30. Hickman ES, Moroni MC, Helin K. The role of p53 and pRB in apoptosis and cancer. Current Opinion Genet Develop 12:60-66, 2002.
31. Lai H, Ma F, Lai S. Identification of the novel role of pRB in eye cancer. J Cell Biochem 88:121-127, 2003.
32. Ginsberg D, Mechta F, Yaniv M, Oren M. Wild-type p53 can downmodulate the activity of various promoters. Proc Natl Acad Sci U S A 88:9979-9983, 1991.
33. Ke H, Pei J, Ni Z, Xia H, Qi H, Woods T, Kelekar A, Tao W. Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). Exp Cell Res 298:329-338, 2004.
34. Menendez S, Khan Z, Coomber DW, Lane DP, Higgins M, Koufali MM, Lain S. Oligomerization of the human ARF tumor suppressor and its response to oxidative stress. J Biol Chem 278:18720-18729, 2003.
35. Ameyar M, Wisniewska M, Weitzman JB. A role for AP-1 in apoptosis: the case for and against. Biochimie 85:747-752, 2003.
36. Hayashi H, Kohno H, Ono T, Yamanoi A, Dhar DK, Ueda S, Rahman MA, Kubota H, Nagasue N. Transforming growth factor-beta 1 induced hepatocyte apoptosis-a possible mechanism for growth of colorectal liver metastasis. Acta Oncol 43:91-97, 2004.
37. Lin Y, Ma W, Benchimol S. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat Genet 26:122-127, 2000.
38. Badock V, Steinhusen U, Bommert K, Wittmann-Liebold B, Otto A. Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line. Cell Death Differ 8:308-315, 2001.
39. Murphy M, Hinman A, Levine AJ. Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev 10:2971-2980, 1996.
40. Fu Y, Sies H, Lei XG. Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling. J Biol Chem 276:43004-43009, 2001.
41. Gentile M, Ahnstrom M, Schon F, Wingren S. Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis. Oncogene 20:7753-7760, 2001.
42. el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B. Definition of a consensus binding site for p53. Nat Genet 1:45-49, 1992.
43. Foord O, Navot N, Rotter V. Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein. Mol Cell Biol 13:1378-1384, 1993.
44. Qian H, Wang T, Naumovski L, Lopez CD, Brachmann RK. Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites. Oncogene 21:7901-7911, 2002.
45. Leskinen P, Virta M, Karp M. One-step measurement of firefly luciferase activity in yeast. Yeast 20:1109-1113, 2003.
46. Amantana A, Vorachek WR, Butler JA, Costa ND, Whanger PD. Effect of copper, zinc and cadmium on the promoter of selenoprotein W in glial and myoblast cells. J Inorg Biochem 91:356-362, 2002.
47. Kelavkar UP, Badr KF. Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene. Proc Natl Acad Sci U S A 96:4378-4383, 1999.
48. Liu B, Khan WA, Hannun YA, Timar J, Taylor JD, Lundy S, Butovich I, Honn KV. 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A 92:9323-9327, 1995.
49. Slingerland JM, Jenkins JR, Benchimol S. The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation. EMBO J 12:1029-1037, 1993.
50. Hachiya M, Chumakov A, Miller CW, Akashi M, Said J, Koeffler PH. Mutant p53 proteins behave in a dominant, negative fashion in vivo. Anticancer Res 14:1853-1860, 1994.