No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 523-524, Issue , 2003, Pages 127-135

  Frank, Norbert ^a   Knauft, Jutta ^a   Amelung, Folker ^a   Nair, Jagadeesan ^a   Wesch, Horst ^a   Bartsch, Helmut ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Carcinogenesis; Chemoprevention; Copper toxicity; Curcumin; LEC rats

Indexed keywords

COPPER; CURCUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANCER PREVENTION; CANCER SURVIVAL; CARCINOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; DIETARY INTAKE; DRUG EFFECT; INCIDENCE; KIDNEY CARCINOMA; LIVER CARCINOMA; MALE; METASTASIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TOXICITY;

CINNAMOMUM VERUM; HEPATITIS C VIRUS; RODENTIA;

EID: 0037294790     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00328-7     Document Type: Conference Paper

References (55)

1. Sawaki M., Enomoto K., Takahashi K., Nakajima Y., Mori M. Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats. Carcinogenesis. 11:1990;1857-1861.
2. Wu J., Forbes A.R., Chen H.S., Cox D.W. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nat. Genet. 7:1994;541-545.
3. Sugawara W., Sugawara C., Katakura M., Takahashi H., Mori M. Copper metabolism in the LEC rat: involvement of induction of metallothionein and disposition of zinc and iron. Experientia. 47:1991;1060-1063.
4. Hamza I., Schäfer M., Klomp L.W., Gitlin J.D. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. Proc. Natl. Acad. Sci. U.S.A. 96:1999;13363-13368.
5. Yamamoto H., Hirose K., Hayasaki Y., Masuda M., Kazusaka A., Fujita S. Mechanism of enhanced lipid peroxidation in the liver of Long-Evans cinnamon (LEC) rats. Arch. Toxicol. 73:1999;457-464.
6. Suzuki K., Miyazawa K., Nakata T., Seo H.G., Sugiyarria T., Taniguchi N. High copper and iron levels and expression of Mn-superoxide dismutase in mutant rats displaying hereditary hepatitis and hepatoma (LEC rats). Carcinogenesis. 14:1993;1881-1884.
7. Yamada T., Sogawa K., Suzuki Y., Izurni K., Agui T., Matsumoto K. Elevation of the level of lipid peroxidation associated with hepatic injury in LEC mutant rat. Res. Commun. Chern. Pathol. Pharmacol. 77:1992;121-124.
8. Yamarnoto F., Kasai K., Togashi Y., Takeichi K., Hori T., Nishimura S. Elevated level of 8-hydroxydeoxyguanosine in DNA of liver, kidneys, and brain of Long-Evans Cinnamon rats. Jpn. J. Cancer Res. 84:1993;508-511.
9. Nair J., Sone K., Nagao M., Barbin A., Bartsch H. Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma. Cancer Res. 56:1996;1267-1271.
10. M. Subramanian, Sreejayan, M.N. Rao, T.P. Devasagayam, B.B. Singh, Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants, Mutat. Res. 311 (1994) 249-255.
11. Brouet I., Ohshima H. Curcumin, an anti-tumor promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem. Biophys. Res. Commun. 206:1995;533-540.
12. Huang M.T., Smart R.C., Wong C.Q., Conney A.H. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48:1988;5941-5946.
13. Huang M.T., Wang Z.Y., Georgiadis C.A., Laskin J.D., Conney A.H. Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene. Carcinogenesis. 13:1992;2183-2186.
14. Huang M.T., Lou Y.R., Ma W., Newmark H.L., Reuhl K.R., Conney A.H. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res. 54:1994;5841-5847.
15. Hecht S.S., Kenney P.M.J., Wang M., Trushin N., Agarwal S., Rao A.V., Upadhyaya P. Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Lett. 137:1999;123-130.
16. Chuang S.E., Kuo M.L., Hsu C.H., Chen C.R., Lin J.K., Lai G.M., Hsieh C.Y., Cheng A.L. Curcumin-containing diet inhibits diethyinitrosamine-induced murine hepatocarcinogenesis. Carcinogenesis. 21:2000;331-335.
17. Mahmoud N.N., Carothers A.M., Grunberger D., Bilinski R.T., Churchill M.R., Martucci C., Newmark H.L., Bertagnolli M.M. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis. 21:2000;921-927.
18. min mice. Carcinogenesis. 22:2001;821-825.
19. Tanaka T., Makita K., Ohnishi M., Hirose Y., Wang A., Mori H., Satoh K., Hara A., Ogawa H. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene. Cancer Res. 54:1994;4653-4659.
20. Rao C.V., Simi B., Reddy B.S. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 55:1995;259-266.
21. Singletary K., MacDonald C., Wallig M., Fisher C. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and DMBA-DNA adduct formation by curcumin. Cancer Lett. 103:1996;137-141.
22. Inano H., Onoda M., Inafuku N., Kubota M., Kamada Y., Osawa T., Kobayashi H., Wakabayashi K. Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays. Carcinogenesis. 20:1999;1011-1018.
23. Ushida J., Sugie S., Kawabata K., Pham Q.V., Tanaka T., Fu M.K., Takeuchi H., Ito Y., Mori H. Chemopreventive effect of curcumin on N-nitrosomethyibenzyiamine-induced esophageal carcinogenesis in rats. Jpn. J. Cancer Res. 91:2000;893-898.
24. Imaida K., Tamano S., Kato K., Ikeda Y., Asamoto M., Takahashi S., Nir Z., Murakoshi M., Nishino H., Shirai T. Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis. Carcinogenesis. 22:2001;467-472.
25. Ciolino H.P., Daschner P.J., Wang T.T., Yeh G.C. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem. Pharmacol. 56:1998;197-206.
26. Goud V.K., Polasa K., Krishnaswamy K. Effect of turmeric on xenobiotic metabolising enzymes. Plant Foods Hum. Nutr. 44:1993;87-92.
27. Piper J.T., Singhal S.S., Salameh M.S., Torman R.T., Awasthi Y.C., Awasthi S. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione-linked detoxification enzymes in rat liver. Int. J. Biochem. Cell Biol. 30:1998;445-456.
28. Lin J.K., Shih C.A. Inhibitory effect of curcumin on xanthine dehydrogenaseloxidase induced by phorbol-12-myristate-1 3-acetate in NIH3T3 cells. Carcinogenesis. 15:1994;1717-1721.
29. Shih C.A., Lin J.K. Inhibition of 8-hydroxydeoxyguanosine formation by curcumin in mouse fibroblast cells. Carcinogenesis. 14:1993;709-712.
30. Reddy S., Aggarwal B.B. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett. 341:1994;19-22.
31. Liu J.Y., Lin S.J., Lin J.K. Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells. Carcinogenesis. 14:1993;857-861.
32. Rao C.V., Simi B., Reddy B.S. Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis. 14:1993;2219-2225.
33. Korutla L., Cheung J.Y., Mendelsohn J., Kumar R. Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Carcinogenesis. 16:1995;1741-1745.
34. Huang M.T., Smart R.C., Wong C.Q., Conney A.H. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48:1988;5941-5946.
35. Huang T.S., Lee S.C., Lin J.K. Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc. Natl. Acad. Sci. U.S.A. 88:1991;5292-5296.
36. Lu Y.R., Chang R.L., Lou Y.R., Huang M.T., Newmark H.L., Reuhl K.R., Conney A.H. Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis. Carcinogenesis. 15:1994;2363-2370.
37. Zhang F., Altorki N.K., Mestre J.R., Subbaramaiah K., Dannenberg A.J. Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis. 20:1999;445-451.
38. Chan M.M., Huang H.I., Fenton M.R., Fong D. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem. Pharmacol. 55:1998;1955-1962.
39. Lu Y.P., Chang R.L., Huang M.T., Conney A.H. Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis. Carcinogenesis. 14:1993;293-297.
40. Jiang M.C., Yang-Yen H.F., Yen J.J., Lin J.K. Curcumin induces apoptosis in immortalized NIH-3T3 and malignant cancer cell lines. Nutr. Cancer. 26:1996;111-120.
41. Arbiser J.L., Klauber X., Rohan R., van-Leeuwen R., Huang M.T., Fisher C., Flynn E., Byers H.R. Curcumin is an in vivo inhibitor of angiogenesis. Mol. Med. 4:1998;376-383.
42. Reddy A.C., Lokesh B.R. Effect of dietary turmeric (Curcurna longa) on iron-induced lipid peroxidation in the rat liver. Food Chem. Toxicol. 32:1994;279-283.
43. Reddy A.C., Lokesh B.R. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology. 107:1996;39-45.
44. K. Kawano, T. Hirashima, S. Mori, S. Bando, K. Yonemoto, F. Abe, T. Natori, Neoplastic and non-neoplastic lesions in aging LEC/Otk rats, in: M. Mori, M.C. Yoshida, N. Takeichi, N. Taniguchi (Eds.), The LEC Rat, Springer Verlag, Tokio, 1991, pp. 298-304.
45. K. Kawano, T. Hirashima, S. Mori, S. Bando, K. Yonemoto, F. Abe, H. Goto, T. Natori, Pathological and laboratory findings of LEC/Otk rats maintained under SPF conditions, in: M. Mori, M.C. Yoshida, N. Takeichi, N. Taniguchi (Eds.), The LEC Rat, Springer Verlag, Tokio, 1991, pp. 30-40.
46. Y. Li, Y. Togashi, N. Takeichi, Abnormal copper accumulation in the liver of LEC rats: a rat form of Wilson's disease, in: M. Mori, M.C. Yoshida, N. Takeichi, N. Taniguchi (Eds.), The LEC Rat, Springer Verlag, Tokio, 1991, pp. 122-132.
47. Larusso N.F. Sclerosing cholangitis: pathogenesis, pathology, and practice. P R Health Sci J. 1:1999;11-17.
48. L.G. Menon, R. Kuttan, G. Kuttan, Anti-metastatic activity of curcumin and catechin, Cancer Lett. (1999) 159-165.
49. Haseeb A., Hadi S.M. Strand scission in DNA induced by curcumin in the presence of copper(II). Cancer Lett. 124:1998;23-30.
50. Bartsch H., Nair J. Ultrasensitive and specific detection methods for exocyclic DNA adducts: markers for lipid peroxidation and oxidative stress. Toxicology. 153:2000;105-114.
51. 4-ethenodeoxycytidine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling. Carcinogenesis. 16:1995;613-617.
52. N. Frank, J. Nair, J. Knauft, F. Amelung, H. Bartsch, Curcumin does not protect LEC rats against hepatic DNA damage and liver carcinogenesis but prevents other tumors and metastases, Proc. Am. Assoc. Cancer. Res. 43 (2002) 867 (Abstract 4294).
53. Nair J., Carmichael P.L., Fernando R.C., Phillips D.H., Strain A.J., Bartsch H. Lipid peroxidation induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis. Cancer Epidemiol. Biomark. 7:1998;435-440.
54. Hatano R., Ebara M., Fukuda H., Yoshikawa M., Sugiura N., Kondo F., Yukawa M., Saisho H. Accumulation of copper in the liver and hepatic injury in chronic hepatitis C. J. Gastroenterol. Hepatol. 15:2000;786-791.
55. Togashi H., Shinzawa H., Matsuo T., Takeda Y., Wakabayashi H., Murayama H., Takahashi T. High content of lipid hydroperoxides in livers from patients with chronic hepatitis C. J. Med. 31:2000;3-14.