Quantification of cardiac and tissue iron by nuclear magnetic resonance relaxometry in a novel murine thalassemia-cardiac iron overload model

Canadian Journal of Cardiology

Volumn 12, Issue 2, 1996, Pages 155-164

  Liu, Peter ^a   Henkelman, Mark ^b   Joshi, J ^b   Hardy, Peter ^b   Butany, Jack ^b   Iwanochko, Mark ^b   Clauberg, Martin ^b   Dhar, Madhu ^b   Mai, Daryl ^b   Waien, Sohail ^b   Olivieri, Nancy ^b  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b NONE

Author keywords

Iron; Nuclear magnetic resonance; Restrictive cardiomyopathy; T2 relaxation

Indexed keywords

EOSIN; FERRIC FERROCYANIDE; FERRITIN; HEMATOXYLIN; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CONTROLLED STUDY; HEART; IMMUNOADSORPTION; IRON OVERLOAD; LIVER; MALE; MOUSE; MUSCLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REGRESSION ANALYSIS; RESTRICTIVE CARDIOMYOPATHY; STAINING; THALASSEMIA; TISSUE LEVEL;

ANIMALS; DISEASE MODELS, ANIMAL; FERRITINS; IRON; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED DBA; MUSCLE, SKELETAL; MYOCARDIUM; THALASSEMIA;

EID: 13344293685     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Niederau C, Fischer R, Sonnenberg A, Steremmel W, Trampisch HJ, Strohmeyer G. Survival and causes of death in cirrhotic and noncirrhotic patients with primary hemochromatosis. N Engl J Med 1985;313:1256-62.
2. Schafer AI, Cheron RG, Dluhy R, et al. Clinical consequences of acquired transfusional iron overload in adults. N Engl J Med 1981;304:319-24.
3. Liu P, Olivieri N. Iron overload cardiomyopathies: new insights into an old disease. Cardiovasc Drugs Ther 1994;8:101-10.
4. Trump BF, Valigorsky JM, Arstila F, Mergner WJ, Kinney TD. The relationship of intracellular pathways of iron metabolism of cellular iron overload and the iron storage disease. Am J Pathol 1973;72:295-324.
5. Olivieri NF, Liu PP, Sher GD, et al. Combined liver and heart transplantation for end-stage iron- induced organ failure in an adult with homozygous beta-thalassemia. N Engl J Med 1994;330:1125-7.
6. Kaltwasser JP, Gottschalk R, Schalk KP, Hartl W. Non-invasive quantitation of liver iron-overload by magnetic resonance imaging. Br J Haematol 1990;74:360-3.
7. Chan PCK, Liu P, Cronin C, Heathcote J, Uldall R. The use of nuclear magnetic resonance imaging in monitoring total body iron in hemodialysis patients with hemosiderosis treated with erythropoietin and phlebotomy. Am J Kidney Dis 1992;19:484-9.
8. Garrick LM, Strano-Paul LA, Hoke JE, et al. Tissue iron deposition in untransfused beta-thalassemic mice. Exp Hematol 1989;17:423-8.
9. Whitney JB III. Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine. Biochem Genet 1978;16:667-71.
10. Johnston DL, Homma S, Liu P, et al. Serial changes in nuclear magnetic resonance relaxation times after myocardial infarction in the rabbit: relationship to water content, severity of ischemia, and histopathology over a six-month period. Magn Reson Med 1988;8:363-79.
11. Liu P, Johnston DL, Brady TJ, Lutrario DM, Okada RD. The alterations of magnetic resonance relaxation parameters in excised myocardial tissue during NMR spectroscopy: the effects of time, environmental exposure and TTC staining. Magn Reson Imaging 1989;7:109-13.
12. 2 values in the human brain: comparison with quantitative assays of iron and ferritin. Radiology 1989;173:521-6.
13. Krocker RM, McVeigh ER, Hardy P, Bronskill MJ, Henkelman RM. In-vivo measurement of NMR relaxation times. Magn Reson Med 1985;2:1-13.
14. Richter GW. The iron loaded cell - the cytopathology of iron storage. Am J Pathol 1978;91:361-404.
15. Buja LM, Roberts WC. Iron in the heart. Etiology and clinical significance. Am J Med 1971;51:209-21.
16. Edwards CQ, Griffen LM, Goldgar D, Drummond C, Skolnick MH, Kushner JP. Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N Engl J Med 1988;318:1355-62.
17. Dabestani A, Child JS, Henze E, et al. Primary hemochromatosis: anatomic and physiologic characteristics of the cardiac ventricles and their response to phlebotomy. Am J Cardiol 1984;54:153-9.
18. Cutler DJ, Isner JM, Bracey AW, et al. Hemochromatosis heart disease: an unemphasized cause of potentially reversible restrictive cardiomyopathy. Am J Med 1980;69:923-8.
19. Engle MA, Erlandson M, Smith CH. Late cardiac complications of chronic, severe, refractory anemia with hemochromatosis. Circulation 1964;30:698-705.
20. Leon MB, Borer JS, Bacharach SL, et al. Detection of early cardiac dysfunction in patients with severe beta-thalassemia and chronic iron overload. N Engl J Med 1979;301:1143-8.
21. Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986;6:24-9.
22. Guyader D, Gandon Y, Deugnier Y, et al. Evaluation of computed tomography in the assessment of liver iron overload. A study of 46 cases of idiopathic hemochromatosis. Gastroenterology 1989;97:737-43.
23. Brittenham GM, Farrell DE, Harris JW, et al. Magnetic-susceptibility measurement of human iron stores. N Engl J Med 1982;307:1671-5.
24. Stark DD, Moseley ME, Bacon BR, et al. Magnetic resonance imaging and spectroscopy of hepatic iron overload. Radiology 1985;154:137-42.
25. Olivieri NF, Berriman AM, Tyler BJ, Davis SA, Francombe WH, Liu PP. Reduction in tissue iron stores with a new regimen of continuous ambulatory intravenous deferoxamine. Am J Hematol 1992;41:61-3.
26. Olivieri NF, Koren G, Matsui D, et al. Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia. Blood 1992;79:2741-8.
27. Olson LJ, Edwards WD, McCall JT, Ilstrup DM, Gersh BJ. Cardiac iron deposition in idiopathic hemochromatosis: histologic and analytic assessment of 14 hearts from autopsy. J Am Coll Cardiol 1987;10:1239-43.
28. Hardy P, Henkelman RM. Transverse relaxation rate enhancement caused by magnetic particles. Magn Reson Imaging 1989;7:265-75.