Novel cationic copolymers of a polyasparthylhydrazide: Synthesis and characterization

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 12, Issue 6, 2005, Pages 377-384

  Cavallaro, Gennara ^a,b   Palumbo, F S ^a   Licciardi, M ^a   Giammona, G ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b Dipartimento di Chimica e Tecnologie Farmaceutiche   (Italy)

Author keywords

3 (Carboxypropyl)Trimethyl Ammonium Chloride; Gene Delivery; Interpolyelectrolytes; Polyaspartylhydrazide; Polycations

Indexed keywords

3 (CARBOXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE; ALPHA,BETA POLY(ASPARTYL HYDRAZIDE); ANION; CARBOXYPROPYLTRIMETHYLAMMONIUM COPOLYMER; CATION; COPOLYMER; DEOXYRIBONUCLEASE II; ELECTROLYTE; POLYASPARTYL HYDRAZIDE; SODIUM CHLORIDE; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CHEMICAL ANALYSIS; DNA DEGRADATION; GEL RETARDATION ASSAY; GENE DELIVERY SYSTEM; MEASUREMENT; PH; PRIORITY JOURNAL; SYNTHESIS; ZETA POTENTIAL;

CARBODIIMIDES; CATIONS; DNA; ELECTROLYTES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDODEOXYRIBONUCLEASES; PEPTIDES; POLYMERS; QUATERNARY AMMONIUM COMPOUNDS;

EID: 27644547873     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540590968792     Document Type: Article

References (19)

1. Abdallah, B., Hassan, A., Benoist, C., Goula, D., Behr, J. P., and Demeneix, B. A. 1996. A powerful non viral vector for in viva gene-transfer in the adult mammalian brain: polyethylenimine. Hum. Gene Ther. 7:1947-1954.
2. Barret, A. J., Heath, M. F., and Dingle, J. T. 1977. In Lysosomes: A Laboratory Handbook, 2nd ed. 19-147. Amsterdam, New York, Oxford: North Holland Publishing Company.
3. Giammona, G., Carlisi, B., Cavallaro, G., Pitarresi, G., and Spampanato, S. 1994. A new water soluble synthetic polymer, α,β- Poly(asparthylhydrazide), as potential plasma expander and drug carrier. J. Control. Rel. 29:63-72.
4. Giammona, G., Carlisi, B., Palazzo, A., and Palazzo, S. 1989. Polimeri carrier sintesi di una nuova poliaspartidrazide. Boll. Chim. Farm. 281:62-64.
5. Godbey, W. T., Wu, K. K., and Mikos, A. G. 1999. Size matters:molecular weight affects the efficiency of poly-(ethylenimine) as a gene delivery vehicle. J. Biomed. Mater. Res. 45:268-275.
6. Hashida, M., Mahado, R. J., Kawabata, K., Myao, M., Nishikawa, Y., and Tokamura Y., 1996. Pharmacokinetics and targeted delivery of proteins and genes. J. Control. Rel. 41:91-97.
7. Hwang, S. J., and Davis, M. E. 2001. Cationic polymers for gene delivery: designs for overcoming barriers to systemic administration. Curr. Opin. Mol. Ther. 3:183-191.
8. Kabanov, V., and Kabanov, V. A. 1995. DNA complexes with polycation for the delivery of genetic material into cell. Bioconjugate Chem. 6:7-20.
9. Lim, Y. B., Kim, S. M., and Park, J. S. 2002. Biodegradable, endosome disruptive, and cationic network-type polymer as higly efficient and nontoxic gene delivery carrier. Bioconjugate Chem. 13:952-957.
10. Maniatis, T., Fritsch, E., and Sambrook, J. 1986. In Molecular Cloning:A Laboratory Manual, 2nd ed. 1824-1825. New York: Cold Spring Harbour Press.
11. Nakajima, N., and Ikada, Y. 1995. Mechanism of amide formation by carbodiimide for bioconjugation in aqueous media. Bioconjugate Chem. 6:123-130.
12. Ogris, M., Steinlein, P., Kursa, M., Mechtler, K., Kircheis, R., and Wagner, E. 1998. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 5:1425-1433.
13. Pedone, E., Cavallaro, G., Richardson, S. C. W., Duncan, R., and Giammona, G. 2001. α,β-Poly(asparthylhydrazide)- glycidyltrimethylammonium chloride copolymers (PAHy-GTA):novel polymers with potential for DNA delivery. J. Control. Rel. 77:139-153.
14. Pouton, C. W., and Seymour, L. W. 1998. Key issues in nonviral gene delivery. Adv Drug Delivery Rev. 34:3-19.
15. Pouyani, T., Harbison, G. S., and Prestwich, G. 1994. Novel hydrogels of hyaluronic acid: synthesis, surface morphology and solid-state NMR. J. Am. Chem. Soc. 116:7515-7522.
16. Richardson, S. C. W., Kolbe, H. V. J., and Duncan, R. 1999. Potential low molecular mass chitosans as DNA delivery system:biocompatibility, body distributionand ability to complex and to protect DNA. Int. J. Pharm. 178:231-243.
17. Sconigher, W. 1995. Rapid microanalytical determination of halogen in organic compound. Microkim. Acta 123-129.
18. Sompayrac, L., and Danna, K. 1981. Efficient infection of monkey cells with DNA of simian virus 40. Proc. Natl. Acad. Sci. USA. 12:7575-7584.
19. Wiethoff, C. M., and Middaught, C. R. 2003. Barriers to nonviral gene delivery. J. Pharm. Sci. 92:203-217.