Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise

American Journal of Physiology - Endocrinology and Metabolism

Volumn 283, Issue 1 46-1, 2002, Pages

  Savasi, Ingrid ^a   Evans, Melissa K ^a   Heigenhauser, George J F ^b   Spriet, Lawrence L ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

100 Oxygen; Acetylcarnitine; Dichloroacetate; Oxidative phosphorylation; Pyruvate dehydrogenase activity; Substrate phosphorylation

Indexed keywords

ACETYL COENZYME A; ACETYLCARNITINE; CREATINE PHOSPHATE; DICHLOROACETIC ACID; LACTIC ACID; PYRUVATE DEHYDROGENASE; SODIUM CHLORIDE;

ADULT; ARTICLE; CORRELATION ANALYSIS; EXERCISE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPEROXIA; MALE; MUSCLE BIOPSY; MUSCLE METABOLISM; NORMAL HUMAN; OXIDATION; OXIDATIVE PHOSPHORYLATION; OXYGENATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; VASTUS LATERALIS MUSCLE;

EID: 0036288084     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00337.2001     Document Type: Article

References (40)

1. 2 uptake at onset of intense exercise in humans
2. Muscle oxygen kinetics at onset of intense dynamic exercise in humans
3. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research
4. Muscle perfusion and oxygenation during local hyperoxia
5. Radioisotopic assays of CoASH and carnitine and their acetylated forms in human skeletal muscle
6. The importance of pyruvate availability to PDC activation and anaplerosis in human skeletal muscle
7. Influence of mitochondrial content on sensitivity of respiratory control
8. Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation during the onset of moderate exercise
9. Anaplerotic processes in human skeletal muscle during brief dynamic exercise
10. Tricarboylic acid cycle intermediate pool size and estimated cycle flux in human muscle during exercise
11. PDH activation by dichloroacetate reduces TCA cycle intermediates at rest but not during exercise in humans
12. Tricarboxylic acid cycle intermediates in human muscle at rest and during prolonged cycling
13. 2 on-kinetics in isolated in situ canine muscle
14. 2 on-kinetics in isolated in situ canine muscle
15. 2
16. Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values
17. Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion
18. Effects of dichloroacetate infusion on human skeletal muscle metabolism at the onset of exercise
19. Regulation of skeletal muscle glycogen phosphorylase and PDH at varying exercise power outputs
20. 2 supply and utilization in men
21. Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia
22. Effect of hyperoxia on aerobic and anaerobic performances and muscle metabolism during maximal cycling exercise
23. 2 kinetics in heavy submaximal exercise by hyperoxia and prior high-intensity exercise
24. Effect of hyperoxia and hypoxia on leg blood flow and pulmonary and leg oxygen uptake at the onset of kicking exercise
25. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia
26. 2 kinetics at the onset of submaximal exercise
27. Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets
28. 2 consumption in trained human skeletal muscle
29. Lactate content and pH in muscle samples obtained after dynamic exercise
30. Tricarboxylic acid cycle intermediates in human muscle during prolonged exercise
31. Anaerobic capacity - Past, present and prospective
32. Anaerobic energy release in skeletal muscle during electrical stimulation in man
33. Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise
34. Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise
35. Interaction of factors determining oxygen uptake at the onset of exercise
36. Effects of hyperoxia on leg blood flow and metabolism during exercise
37. Mechanisms of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids
38. 2 breathing on RQ, blood flow, and developed tension in in situ dog muscle