Effect of polyethylenimine on recombinant adeno-associated virus midiated insulin gene therapy

Journal of Gene Medicine

Volumn 7, Issue 10, 2005, Pages 1311-1321

  Hsu, Paul Yueh Jen ^a   Yang, Ya Wun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Diabetes Millitus; Gene therapy; Insulin; PEI; rAAV

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; FURIN; HEPARIN; INSULIN; PARVOVIRUS VECTOR; POLYETHYLENEIMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; ENDOCYTOSIS; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; TRANSGENE; TUMOR CELL LINE; VIRAL GENE THERAPY; VIRUS RECOMBINANT;

ANIMALS; BODY WEIGHT; CELL LINE, TUMOR; DEPENDOVIRUS; DIABETES MELLITUS, EXPERIMENTAL; ENDOCYTOSIS; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; INSULIN; LIVER; MALE; MICE; MICE, INBRED C57BL; POLYETHYLENEIMINE;

ADENO-ASSOCIATED VIRUS; ANIMALIA; PARVOVIRUS;

EID: 27644502289     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.779     Document Type: Article

References (44)

1. Flotte TR, Carter BJ. Adeno-associated virus vectors for gene therapy. Gene Ther 1995; 2: 357-362.
2. Summerford C, Samulski RJ. Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol 1998; 72: 1438-1445.
3. 5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat Med 1999; 5: 78-82.
4. Qing K, Mah C, Hansen J, Zhou S, Dwarki V, Srivastava A. Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2. Nat Med 1999; 5: 71-77.
5. Yang YW, Kotin RM. Glucose-responsive gene delivery in pancreatic Islet cells via recombinant adeno-associated viral vectors. Pharm Res 2000; 17: 1056-1061.
6. Yang YW, Hsieh YC, Chao CK. Glucose-modulated transgene expression via recombinant adeno-associated virus. Pharm Res 2002; 19: 968-975.
7. Lau JY. Adeno-associated virus as a gene delivery vector for liver cells. J Hepatol 1999; 31: 385.
8. Wang Z, Ma HI, Li J, Sun L, Zhang J, Xiao X. Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo. Gene Ther 2003; 10: 2105-2111.
9. Kircheis R, Wightman L, Wagner E. Design and gene delivery activity of modified polyethylenimines. Adv Drug Deliv Rev 2001; 53: 341-358.
10. Thomas M, Klibanov AM. Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A 2002; 99: 14 640-14 645.
11. Thomas M, Klibanov AM. Non-viral gene therapy: polycation-mediated DNA delivery. Appl Microbiol Biotechnol 2003; 62: 27-34.
12. Boussif O, Lezoualc'h F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 1995; 92: 7297-7301.
13. Oh YK, Suh D, Kim JM, Choi HG, Shin K, Ko JJ. Polyethylenimine-mediated cellular uptake, nucleus trafficking and expression of cytokine plasmid DNA. Gene Ther 2002; 9: 1627-1632.
14. Duncan R, Pratten MK, Lloyd JB. Mechanism of polycation stimulation of pinocytosis. Biochim Biophys Acta 1979; 587: 463-475.
15. Bouri K, Feero WG, Myerburg MM, et al. Polylysine modification of adenoviral fiber protein enhances muscle cell transduction. Hum Gene Ther 1999; 10: 1633-1640.
16. McKay TR, MacVinish LJ, Carpenter B, et al. Selective in vivo transfection of murine biliary epithelia using polycation-enhanced adenovirus. Gene Ther 2000; 7: 644-652.
17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
18. Goldfine ID, German MS, Tseng HC, et al. The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nat Biotechnol 1997; 15: 1378-1382.
19. Grimm D, Kern A, Rittner K, Kleinschmidt JA. Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum Gene Ther 1998; 9: 2745-2760.
20. Yang YW, Hsieh YC. Regulated secretion of proinsulin/insulin from human hepatoma cells transduced by recombinant adeno-associated virus. Biotechnol Appl Biochem 2001; 33: 133-140.
21. Yang YW, Hsieh YC. Protamine sulfate enhances the transduction efficiency of recombinant adeno-associated virus-mediated gene delivery. Pharm Res 2001; 18: 922-927.
22. Yang YW, Chao CK. Incorporation of calcium phosphate enhances recombinant adeno-associated virus-mediated gene therapy in diabetic mice. J Gene Med 2003; 5: 417-424.
23. Sanlioglu S, Benson PK, Yang J, Atkinson EM, Reynolds T, Engelhardt JF. Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation. J Virol 2000; 74: 9184-9196.
24. Goula D, Benoist C, Mantero S, Merlo G, Levi G, Demeneix BA. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther 1998; 5: 1291-1295.
25. Goula D, Becker N, Lemkine GF, et al. Rapid crossing of the pulmonary endothelial barrier by polyethylenimine/DNA complexes. Gene Ther 2000; 7: 499-504.
26. Bonsted A, Engesaeter BO, Hogset A, et al. Transgene expression is increased by photochemically mediated transduction of polycation-complexed adenoviruses. Gene Ther 2004; 11: 152-160.
27. Fasbender A, Zabner J, Chillon M, et al. Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo. J Biol Chem 1997; 272: 6479-6489.
28. Kaplan JM, Pennington SE, St George JA, et al. Potentiation of gene transfer to the mouse lung by complexes of adenovirus vector and polycations improves therapeutic potential. Hum Gene Ther 1998; 9: 1469-1479.
29. Zolotukhin S, Byrne BJ, Mason E, et al. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther 1999; 6: 973-985.
30. Thule PM, Liu JM. Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Ther 2000; 7: 1744-1752.
31. Godbey WT, Wu KK, Mikos AG. Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability. Biomaterials 2001; 22: 471-480.
32. Kichler A, Leborgne C, Coeytaux E, Danos O. Polyethylenimine-mediated gene delivery: a mechanistic study. J Gene Med 2001; 3: 135-144.
33. Merlin JL, N'Doye A, Bouriez T, Dolivet G. Polyethylenimine derivatives as potent nonviral vectors for gene transfer. Drug News Perspect 2002; 15: 445-451.
34. Croyle MA, Cheng X, Sandhu A, Wilson JM. Development of novel formulations that enhance adenoviral-mediated gene expression in the lung in vitro and in vivo. Mol Ther 2001; 4: 22-28.
35. German MS. Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates. Proc Natl Acad Sci U S A 1993; 90: 1781-1785.
36. German MS, Wang J. The insulin gene contains multiple transcriptional elements that respond to glucose. Mol Cell Biol 1994; 14: 4067-4075.
37. Burkhardt BR, Loiler SA, Anderson JA, et al. Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells. Ann N Y Acad Sci 2003; 1005: 237-241.
38. Seisenberger G, Ried MU, Endress T, Buning H, Hallek M, Brauchle C. Real-time single-molecule imaging of the infection pathway of an adeno-associated virus. Science 2001; 294: 1929-1932.
39. Sugiyama A, Hattori S, Tanaka S, et al. Defective adeno-associated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice. Horm Metab Res 1997; 29: 599-603.
40. Olson DE, Paveglio SA, Huey PU, Porter MH, Thule PM. Glucose-responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats. Hum Gene Ther 2003; 14: 1401-1413.
41. Blankinship MJ, Gregorevic P, Allen JM, et al. Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6. Mol Ther 2004; 10: 671-678.
42. Burger C, Gorbatyuk OS, Velardo MJ, et al. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol Ther 2004; 10: 302-317.
43. Rabinowitz JE, Bowles DE, Faust SM, Ledford JG, Cunningham SE, Samulski RJ. Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups. J Virol 2004; 78: 4421-4432.
44. Lebherz C, Gao G, Louboutin JP, Millar J, Rader D, Wilson JM. Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia. J Gene Med 2004; 6: 663-672.