Potentiation of gene transfer to the mouse lung by complexes of adenovirus vector and polycations improves therapeutic potential

Human Gene Therapy

Volumn 9, Issue 10, 1998, Pages 1469-1479

  Kaplan, Johanne M ^a   Pennington, Sarah E ^a   St George, Judith A ^a   Woodworth, Lisa A ^a   Fasbender, Al ^b   Marshall, John ^a   Cheng, Seng H ^a   Wadsworth, Samuel C ^a   Gregory, Richard J ^a   Smith, Alan E ^a  

^a GENZYME CORPORATION   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; POLYCATION;

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE THERAPY; GENE TRANSFER; HISTOLOGY; LUNG; MOUSE; NONHUMAN; RESPIRATORY EPITHELIUM; SMOOTH MUSCLE; TARGET ORGAN; TRANSGENE; VASCULAR ENDOTHELIUM; VIRUS RECOMBINANT;

EID: 17344366110     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.10-1469     Document Type: Article

References (11)

1. ARCASOY, S.M., LATOCHE, J.D., GONDOR, M., PITT, B.R., and PILEWSKI, J.M. (1997). Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro. Gene Ther. 4, 32-38.
2. ARMENTANO, D., ZABNER, J., SACKS, C., SOOKDEO, C.C., SMITH, M.P., ST. GEORGE, J.A., WADSWORTH, S.C., SMITH, A.E., and GREGORY, R.J. 1997. Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. J. Virol. 71, 2408-2416.
3. BEACHEY, E.H. (1986). Type-specific opsonic antibodies evoked with a synthetic peptide of streptococca; M protein conjugated to polylysine without adjuvant. Infect. Immun. 51, 362-364.
4. BERGELSON, J.M., CUNNINGHAM, J.A., DROGUETT, G., KURTJONES, E.A., KRITHIVAS, A., HONG, J.S., HORWITZ, M.S., CROWELL, R.L., and FINBERG, R.W. (1997). Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275, 1320-1323.
5. DOUGLAS, J.T., ROGERS, B.E., ROSENFELD, M.E., MICHAEL, S.I., FENG, M., and CURIEL, D.T. (1996). Targeted gene delivery by tropism-modified adenoviral vectors. Nature Biotcch. 14, 1574-1578.
6. FASBENDER, A., ZABNER, J., CHILLON, M., MONINGER, T.O., PUGA, A.P., DAVIDSON, B.L., and WELSH, M.J. (1997). Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo. J. Biol. Chem. 272, 6479-6489.
7. GOLDMAN, M.J., and WILSON, J.M. (1995). Expression of αvβ integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J. Virol. 69 5951-5958.
8. GOLDMAN, M., SU, Q., and WILSON, J.M. (1996). Gradient of RGD-dependent entry of adenoviral vector in nasal and intrapulmonary epithelia: Implications for gene therapy of cystic fibrosis. Gene Ther. 3, 811-818.
9. GOODING, L.R. (1979). Specificities of killing by T lymphocytes generated against syngeneic SV40 transformants: Studies employing recombinants within the H-2 complex. J. Immunol. 122, 1002-1008.
10. GRUBB, B.R., PICKLES, R.J., YE, H., YANKASKAS, J.R., VICK, R.N., ENGELHARDT, J.F., WILSON, J.M., JOHNSON, L.G., and BOUCHER, R.C. (1994). Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature (London) 371, 802-806.
11. HEDIN, H., and RICHTER, W. (1982). Pathomechanisms of dextraninduced anaphylactoid/anaphylactic reactions in man. Int. Arch. Allergy Appl. Immunol. 68, 122-126.