Sequence variation in the 3′-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD)

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 139 B, Issue 1, 2005, Pages 1-6

  Feng, Yu ^a   Wigg, Karen G ^a   Makkar, Rohit ^a   Ickowicz, Abel ^b   Pathare, Tejaswee ^b   Tannock, Rosemary ^b   Roberts, Wendy ^b   Malone, Molly ^b   Kennedy, James L ^c   Schachar, Russell ^b   Barr, Cathy L ^a,b,d  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

ADHD; Association; Dopamine transporter; Gene; Genetics

Indexed keywords

DNA;

3' UNTRANSLATED REGION; ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; BSTUI GENE; DAT1 GENE; DNA POLYMORPHISM; DRA1 GENE; GENE; GENE EXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IN VITRO STUDY; MSPI GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TANDEM REPEAT;

3' UNTRANSLATED REGIONS; ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BASE SEQUENCE; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HAPLOTYPES; HUMANS; MICE; MINISATELLITE REPEATS; MOLECULAR SEQUENCE DATA; VARIATION (GENETICS);

RHODOCOCCUS RHODOCHROUS;

EID: 27644464349     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30190     Document Type: Article

References (44)

1. Barr CL, Feng Y, Wigg K, Bloom S, Roberts W, Malone M, Schachar R, Tannock R, Kennedy JL. 2000a. Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorder. Mol Psychiatry 5(4):405-409.
2. Barr CL, Feng Y, Wigg K, Roberts W, Malone M, Schachar R, Tannock R, Gruen JR, Goei V, Kennedy JL. 2000b. Identification of polymorphisms in the GABAB receptor gene and linkage study of attention-deficit hyperactivity disorder. Gene Funct Dis 5-6:1-8.
3. Barr CL, Wigg KG, Bloom S, Schachar R, Tannock R, Roberts W, Malone M, Kennedy JL. 2000c. Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. Am J Med Genet 96(3):262-267.
4. Barr CL, Wigg KG, Feng Y, Zai G, Malone M, Roberts W, Schachar R, Tannock R, Kennedy JL. 2000d. Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor. Mol Psychiatry 5(5):548-551.
5. Barr CL, Feng Y, Wigg KG, Schachar R, Tannock R, Roberts W, Malone M, Kennedy JL. 2001. 5′ untranslated region of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. Am J Med Genet (Neuropsychiatr Genet) 105:84-90.
6. Barr CL, Xu C, Kroft J, Feng Y, Wigg K, Zai G, Tannock R, Schachar R, Malone M, Roberts W, Nothen MM, Grunhage F, Vandenbergh DJ, Uhl G, Sunohara G, King N, Kennedy JL. 2001. Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder. Biol Psychiatry 49(4):333-339.
7. Boyle MH, Offord DR, Racine Y, Fleming JE, Szatmari P, Sanford M. 1993. Evaluation of the revised Ontario Child Health Study scales. J Child Psychol Psychiatry 34(2):189-213.
8. Chen CK, Chen SL, Mill J, Huang YS, Lin SK, Curran S, Purcell S, Sham P, Asherson P. 2003. The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. Mol Psychiatry 8(4):393-396.
9. Cheon KA, Ryu YH, Kim YK, Namkoong K, Kim CH, Lee JD. 2003. Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder. Eur J Nucl Med Mol Imaging 30(2):306-311. Epub 2002 Nov 29.
10. Clayton D. 1999. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65(4):1170-1177.
11. Conners CK. 1997. Conners' rating scales-revised. Toronto, Canada, Multi-Health Systems Inc.
12. Cook EH Jr., Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL. 1995. Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet 56(4):993-998.
13. Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S, Ozbay F, Yazgan Y, Simonoff E, Thompson M, Taylor E, Asherson P. 2001. Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry 6(4):425-428.
14. Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ. 1999. Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet 354(9196):2132-2133.
15. Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S. 2001. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J 1(2):152-156.
16. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M. 1997. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 2(4):311-313.
17. Greenwood TA, Kelsoe JR. 2003. Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene. Genomics 82(5):511-520.
18. Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Shaw SH, Kelsoe JR. 2002. Segmental linkage disequilibrium within the dopamine transporter gene. Mol Psychiatry 7(2):165-173.
19. Grünhage F, Schulze TG, Muller DJ, Lanczik M, Franzek E, Albus M, Borrmann-Hassenbach M, Knapp M, Cichon S, Maier W, Rietschel M, Propping P, Nöthen MM. 2000. Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (D0AT1). Mol Psychiatry 5(3):275-282.
20. Heinz A, Goldman D, Jones DW, Palmour R, Hommer D, Gorey JG, Lee KS, Linnoila M, Weinberger DR. 2000. Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology 22(2):133-139.
21. Holmes J, Payton A, Barrett JH, Hever T, Fitzpatrick H, Trumper AL, Harrington R, McGuffin P, Owen M, Oilier W, Worthington J, Thapar A. 2000. A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder. Mol Psychiatry 5(5):523-530.
22. Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. 2000. Prediction of dopamine transporter binding availability by genotype: A preliminary report. Am J Psychiatry 157(10):1700-1703.
23. Kirley A, Lowe N, Hawi Z, Mullins C, Daly G, Waldman I, McCarron M, O'Donnell D, Fitzgerald M, Gill M. 2003. Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD. Am J Med Genet 121B(1):50-54.
24. Kovacs M. 1995. Manual: The Children's depression inventory. Toronto, Canada: Multi-Health Systems.
25. Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K. 2000. Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: Effects of methylphenidate as measured by single photon emission computed tomography. Neurosci Lett 285(2):107-110.
26. Martinez D, Gelernter J, Abi-Dargham A, van Dyck CH, Kegeles L, Innis RB, Laruelle M. 2001. The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. Neuropsychopharmacology 24(5):553-560.
27. Mill J, Asherson P, Browes C, D'Souza U, Craig I. 2002. Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet 114(8):975-979.
28. Miller GM, Madras BK. 2002. Polymorphisms in the 3′-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Mol Psychiatry 7(1):44-55.
29. Miller SA, Dykes DD, Polesky HF. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215.
30. Muglia P, Jain U, Inkster B, Kennedy JL. 2002. A quantitative trait locus analysis of the dopamine transporter gene in adults with ADHD. Neuropsychopharmacology 27(4):655-662.
31. Palmer CG, Bailey JN, Ramsey C, Cantwell D, Sinsheimer JS, Del'Homme M, McGough J, Woodward JA, Asarnow R, Asarnow J, Nelson S, Smalley SL. 1999. No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample. Psychiatr Genet 9(3):157-160.
32. Reynolds CR, Richmond BO. 1985. What I think and feel (RCMAS). Los Angeles, CA: Western Psychological Services.
33. Roman T, Szobot C, Martins S, Biederman J, Rohde LA, Hutz MH, Schmitz M, Polanczyk G, Eizirik M. 2002. Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder. Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Pharmacogenetics 12(6):497-499.
34. Semel E, Wing E, Secord W. 1995. Clinical evaluation of language fundamentals-third edition (CELF-3). San Antonio, TX: The Psychological Corporation.
35. Tannock R, Hum M, Masellis M, Humphries T, Schachar R. 2004. Teacher telephone interview for Children's academic performance, attention, behavior and learning: DSM-IV Version (TTI-IV). Toronto, Canada: The Hospital for Sick Children, Unpublished Document.
36. Thapar A, Holmes J, Poulton K, Harrington R. 1999. Genetic basis of attention deficit and hyperactivity. Br J Psychiatry 174:105-111.
37. Todd RD, Jong YJ, Lobos EA, Reich W, Heath AC, Neuman RJ. 2001. No association of the dopamine transporter gene 3′ VNTR polymorphism with ADHD subtypes in a population sample of twins. Am J Med Genet 105(8):745-748.
38. Ueno S, Nakamura M, Mikami M, Kondoh K, Ishiguro H, Arinami T, Komiyama T, Mitsushio H, Sano A, Tanabe H. 1999. Identification of a novel polymorphism of the human dopamine transporter (DAT1) gene and the significant association with alcoholism. Mol Psychiatry 4(6):552-557.
39. van Dyck CH, Quinlan DM, Cretella LM, Staley JK, Malison RT, Baldwin RM, Seibyl JP, Innis RB. 2002. Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder. Am J Psychiatry 159(2):309-312.
40. Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR. 1992. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 14(4):1104-1106.
41. Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, Cleveland HH, Sanders ML, Gard JM, Stever C. 1998. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: Heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 63(6):1767-1776.
42. Wechsler DI. 1991. Examiner's manual: Wechsler intelligence scale for children-third edition. New York, NY: Psychological Corporation.
43. Wilkinson GS. 1993. Wide range achievement test 3-revision 3. Wilmington, DE: Jastak Associates.
44. Winsberg BG, Comings DE. 1999. Association of the dopamine transporter gene (DAT1) with poor methylphenidate response. J Am Acad Child Adolesc Psychiatry 38(12):1474-1477.