Identification of a novel polymorphism of the human dopamine transporter (DAT1) gene and the significant association with alcoholism

Molecular Psychiatry

Volumn 4, Issue 6, 1999, Pages 552-557

  Ueno, S ^a   Nakamura, M ^a   Mikami, M ^a   Kondoh, K ^a   Ishiguro, H ^b   Arinami, T ^b   Komiyama, T ^c   Mitsushio, H ^c   Sano, A ^a   Tanabe, H ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

5p15.3; Alcoholism; Association study; Human dopamine transporter (DAT1); Polymorphism; Schizophrenia

Indexed keywords

DOPAMINE TRANSPORTER;

ADULT; ALCOHOLISM; ARTICLE; CHROMOSOME 5P; DNA POLYMORPHISM; FEMALE; GENE DOSAGE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHIATRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHIZOPHRENIA; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 0032760589     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000562     Document Type: Article

References (26)

1. 1 Cannon TD, Kaprio J, Lonnqvist J, Huttunen M, Koskenvuo M. The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch Gen Psychiatry 1998; 55: 67-74.
2. 2 Uhl GR, Elmer GI, Labuda MC, Pinkens RW. Genetic influences in drug abuse. In: Bloom FE, Dupfer DJ (eds). Psychopharmacology The Fourth Generation of Progress. Raven Press: New York, 1995.
3. 3 Begleiter H, Kissin B (eds). The Genetics of Alcoholism. Oxford University Press: New York, 1995.
4. 4 Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D. The Roscommon Family Study. 1, Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Can Psychiatry 1993; 50: 527-540.
5. 5 Silverman JM, Greenberg DA, Altstiel LD, Siever LJ, Mohs RC, Smith CJ et al. Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree, Am J Med Genet 1996; 67: 162-171.
6. 6 Kinney DK, Holzman PS, Jacobsen B, Jansson L, Faber B, Hildebrand W et al. Thought disorder in schizophrenic and control adoptees and their relatives. Arch Gen Psychiatry 1997; 54: 475-479.
7. 7 Ishiguro H, Arinami T, Saito T, Akazawa S, Enomoto M, Mitushio H et al. Association study between the -141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism. Alcohol Clin Exp Res 1998; 22: 845-848.
8. 8 Arinami T, Gao M, Hamaguchi H, Toru M. A functional polymorphism in the promoter region of the dopamine D2 ruceptor gene is associated with schizophrenia. Hum Mol Genet 1997; 6: 577-582.
9. 9 Gelernter J, O'Malley SM, Risch N, Kranzler HR, Krystal J, Merikangas K et al. No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA 1991; 266:1801-1807.
10. 10 Vandenbergh DJ, Persico AM. A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic Taq I RFLPs. Mol Brain Res 1992; 15: 161-166.
11. 11 Tiihonen J, Kuikka J, Bergstrom K, Hakola P, Karhu J, Ryynauen OP et al. Altered striatal dopamine re-uptake situ densities in habitually violent and non-violent alcoholics. Nature Med 1995; 1: 654-657.
12. 12 Sano A, Kondoh K, Kakimoto Y, Kondo I. A 40-nucleotide repeat polymorphism in the human dopamine transporter gene. Hum Genet 1993; 91: 405-406.
13. 13 Muramatsu T, Higuchi S. Dopamine transporter gene polymorphism and alcoholism. Biochem Biophys Res Comm 1995; 211: 28-32.
14. 14 Schmidt LG, Harms H, Kuhn S, Rommelspacher H, Sander T. Modification of alcohol withdrawal by the A9 allele of the dopamine transporter gene. Am J Psychiat 1998; 155: 474-478.
15. 15 Persico AM, Vandenbergh DJ, Smith SS, Uhl GR. Dopamine transporter gene polymorphisms are not associated with polysubstance abuse. Biol Psychiatry 1993; 34: 265-267.
16. 16 Blum K, Braverman ER, Wu S, Cull JG, Ghen TJ, Gill J et al Association of polymorphisms of dopamine D2 receptor (DRD2), and dopamine transporter (DAT1) genes with schizoid/avoidant behaviors (SAB). Mol Psychiatry 1997; 2: 233-246.
17. 17 Inada T, Sugita T, Dobashi I, Inagaki A, Kitao Y, Matsuda G et al. Dopamine transporter gene polymorphism and psychiatric symptoms seen in schizophrenic patients at their first episode. Am J Med Genet 1996; 67: 406-408.
18. 18 Maier W, Minges J, Eckstein N, Brodski C, Albus M, Lerer B et al. Genetic relationship between dopamine transporter gene and schizophrenia: linkage and association. Schizophr Res 1996; 20: 175-180.
19. 19 Kawarai T, Kawakami H, Yamamura Y, Nakamura S. Structure and organization of the gene encoding human dopamine transporter. Gene 1997; 195: 11-18.
20. 20 Mehta CR, Patel NR. A network algorithm for performing Fisher's exact test in rxc contingency tables. JASA 1983; 78: 427-434.
21. 21 Cook Jr EH, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Keiffer JE et al. Association of attention-deficit disorder and this dopamine transporter gene. Am J Hum Genet 1995; 56: 993-998.
22. 22 Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW et al. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 1992; 141: 1104-1106.
23. 23 Inada T, Polk K, Purser C, Hume A, Hoskins B, Ho IK et al. Behavioral and neurochemical effects of continuous infusion of cocaine in rats. Neuropharmacology 1992; 31: 701-708.
24. 24 Iyo M, Maeda Y, Inada T, Kitao Y, Sasaki H, Fukui S. The effects of a selective cAMP phosphodiesterase inhibitor, rolipram, on methamphetamine-induced behavior. Neuropsychopharmacology 1995; 13: 33-39.
25. 25 Persico AM, Wang ZW, Black DW, Andreasen NC, Uhl GR, Crowe RR. Exclusion of close linkage of the dopamine transporter gene with schizophrenia spectrum disorders. Am J Psychiatry 1995; 152: 134-136.
26. 26 Persico AM, Macciardi F. Genotypic association between dopamine transporter gene polymorphisms and schizophrenia. Am J Med Genet 1997; 74: 53-57.