Glycation free adduct accumulation in renal disease: The new AGE

Pediatric Nephrology

Volumn 20, Issue 11, 2005, Pages 1515-1522

  Thornalley, Paul J ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

Chronic renal failure; Glycation; Haemodialysis; Peritoneal dialysis; Uraemia

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; UREMIC TOXIN;

CHRONIC KIDNEY FAILURE; DISEASE ASSOCIATION; EDITORIAL; EXTRACELLULAR MATRIX; GLYCATION; HEMODIALYSIS; HUMAN; KIDNEY CLEARANCE; KIDNEY FAILURE; PERITONEAL DIALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; UREMIA; URINARY EXCRETION; VASCULAR DISEASE;

AMINO ACID OXIDOREDUCTASES; FOOD ANALYSIS; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; IMIDAZOLES; KIDNEY; KIDNEY DISEASES;

EID: 27644455847     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-005-2011-9     Document Type: Editorial

References (65)

1. Thornalley PJ (1999) Clinical significance of glycation. Clin Lab 45:263-273
2. Thornalley PJ, Battah S, Ahmed N, Karachalias N, Agalou S, Babaei-Jadidi R, Dawnay A (2003) Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry. Biochem J 375:581-592 10.1042/BJ20030763
3. ∈-(carboxymethyl)lysine independently of glycohaemoglobin concentrations. Diabetologia 42:603-607 10.1007/s001250051201
4. Sebekova K, Podracka L, Blazicek P, Syrova D, Heidland A, Schinzel R (2001) Plasma levels of advanced glycation end products in children with renal disease. Pediatr Nephrol 16:1105-1112 10.1007/s004670100038
5. Fukunaga Y, Katsuragi Y, Izumi T, Sakiyama F (1982) Fluorescence characteristics of kynurenine and N′-formylkynurenine. Their use as reporters of the environment of tryptophan 62 in hen egg-white lysozyme. J Biochem 92:129-141 7118867
6. Odetti P, Fogarty J, Sell DR, Monnier VM (1992) Chromatographic quantitation of plasma and erythrocyte pentosidine in diabetic and uremic subjects. Diabetes 41:153-159 1733803
7. Wilker SC, Chellan P, Arnold BM, Nagaraj RH (2001) Chromatographic quantification of argpyrimidine, a methylglyoxal-derived product in tissue proteins. Anal Biochem 290:353-358 10.1006/abio.2001.4992
8. Verzijl N, DeGroot J, Thorpe SR, Bank RA, Shaw JN, Lyons TJ, Bijlsma JWJ, Lafeberi FPJG, Baynes JW, TeKoppele JM (2000) Effect of collagen turnover on the accumulation of advanced glycation endproducts. J Biol Chem 275:39027-39031 10.1074/jbc.M006700200
9. Goldberg AL (2003) Protein degradation and protection against misfolded or damaged proteins. Nature 426:895-899 10.1038/nature02263
10. Gerner C, Vejda S, Gelbmann D, Bayer E, Gotzmann J, Schulte-Hermann R, Mikulitis W (2002) Concomitant determination of absolute values of cellular protein amounts, synthesis rates, and turnover rates by quantitative proteome profiling. Mol Cell Proteomics 1:528-537 10.1074/ mcp.M200026-MCP200
11. Agalou S, Ahmed N, Babaei-Jadidi R, Dawnay A, Thornalley PJ (2005) Profound mishandling of protein glycation degradation products in uremia and dialysis. J Am Soc Nephrol 16:1471-1485 10.1681/ASN.2004080635
12. Suzuki D, Miyata T, Saotome N, Horie K, Inagi R, Yasuda Y, Uchida K, Izuhara Y, Yagame M, Sakai H, Kurokawa K (1999) Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions. J Am Soc Nephrol 10:822-832 10203367
13. Delpierre G, Vertommen D, Communi D, Rider MH, Van Schaftingen E (2004) Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin. J Biol Chem 279:27613-27620 10.1074/jbc.M402091200
14. Szwergold BS, Howell S, Beisswenger PJ (2001) Human fructosamine-3-kinase. Purification, sequencing, substrate specificity, and evidence of activity in vivo. Diabetes 50:2139-2147 11522682
15. Delpierre G, Collard F, Fortpied J, Van Schaftingen E (2002) Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes. Biochem J 365:801-808 11975663
16. Layton GJ, Allen TJ, Jerums G (1990) Longitudinal evaluation of the renal clearance of glycated albumin in the diabetic rat. Diabetes Res Clin Pract 8:221-226 10.1016/0168-8227(90)90120-I
17. Takahashi M, Fujii J, Teshima T, Suzuki K, Shiba T, Taniguchi N (1993) Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression. Gene 127:249-253 10.1016/0378-1119(93)90728-L
18. Ahmed N, Dobler D, Dean M, Thornalley PJ (2005) Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity. J Biol Chem 280:5724-5732 10.1074/jbc.M410973200
19. Thornalley PJ (2003) Glyoxalase I - structure, function and a critical role in the enzymatic defence against glycation. Biochem Soc Trans 31:1343-1348 14641060
20. ∈ -(1-carboxyethyl)lysine-modified albumin. Biochem J 364:1-14 11988070
21. Gallet X, Charloteaux B, Thomas A, Braseur R (2000) A fast method to predict protein interaction sites from sequences. J Mol Biol 302:917-926 10.1006/jmbi.2000.4092
22. Ahmed N, Thornalley PJ, Dawczynski J, Franke S, Strobel J, Stein G, Haik JR GM (2003) Methylglyoxal-derived hydroimidazolone advanced glycation endproducts of human lens proteins. Invest Ophthalmol Vis Sci 44:5287-5292 10.1167/iovs.03-0573
23. Thornalley PJ (2005) Dicarbonyl intermediates in the Maillard reaction. Ann N Y Acad Sci 1043:118
24. Thornalley PJ, Argirova M, Ahmed N, Mann VM, Argirov OK, Dawnay A (2000) Mass spectrometric monitoring of albumin in uraemia. Kidney Int 58:2228-2234 10.1111/j.1523-1755.2000.00398.x
25. Ahmed N, Thornalley PJ (2002) Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatisation with aminoquinolyl-N-hydroxysuccimidyl-carbamate and intrinsic fluorescence. Biochem J 364:15-24 11988071
26. Henle T (2003) AGEs in foods: Do they play a role in uremia? Kidney Int 63:S145-S147 10.1046/j.1523-1755.63.s84.16.x
27. Johnson RN, Easdale RW, Tatnell M, Baker JR (1991) Significance of variation in turnover of glycated albumin on indexes of diabetic control. Clin Chim Acta 198:229-238 10.1016/0009-8981(91)90356-H
28. Ahmed N, Thornalley PJ, Luthen R, Haussinger D, Sebekova K, Schinzel R, Voelker W, Heidland A (2004) Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis. J Hepatol 41:913-919 10.1016/j.jhep.2004.08.007
29. Russo LM, Bakris GL, Comper WD (2002) Renal handling of albumin: A critical review of basic concepts and perspective. Am J Kidney Dis 39:899-919 10.1053/ajkd.2002.32764
30. Cha T, Tahara Y, Yamoto E, Yoneda H, Ikegami H, Noma Y, Shima K, Ogihara T (1991) Renal handling of glycated albumin in non-insulin-dependent diabetes mellitus with nephropathy. Diabetes Res Clin Pract 12:149-156 10.1016/0168-8227(91)90071-K
31. Bendayan M, Londono I (1996) Reabsorption of native and glycated albumin by renal proximal tubular epithelial cells. Am J Physiol 40:F261-F268
32. Greive KA, Balazs NDH, Comper WD (2001) Protein fragments in urine have been considerably underestimated by various protein assays. Clin Chem 47:1717-1719 11514414
33. Ahmed N, Babaei-Jadidi R, Howell SK, Beisswenger PJ, Thornalley PJ (2005) Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes. Diabetologia (in press)
34. Koschinsky T, He C-J, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitman K, Vlassara H (1997) Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci U S A 94:6474-6479
35. Cai WJ, Gao QD, Zhu L, Peppa M, He CJ, Vlassara H (2002) Oxidative stress-inducing carbonyl compounds from common foods: Novel mediators of cellular dysfunction. Mol Med 8:337-346 12393931
36. Vlassara H, Cai WJ, Crandall J, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield EJ (2002) Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci U S A 99:15596-15601
37. Uribarri J, Peppa M, Cai WJ, Goldberg T, Lu M, Baliga S, Vassalotti JA, Vlassara H (2003) Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients. Am J Kidney Dis 42:532-538 10.1016/S0272-6386(03)00779-0
38. Ahmed N, Mirshekar-Syahkal B, Kennish L, Karachalias N, Babaei-Jadidi R, Thornalley PJ (2005) Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detection. Mol Nutr Food Res 49:691-699 10.1002/ mnfr.200500008
39. He C, Sabol J, Mitsuhashi T, Vlassara H (1999) Dietary glycotoxins. Inhibition of reactive products by aminoguanidine facilitates renal clearance and reduced tissue sequestration. Diabetes 48:1308-1315 10342821
40. Thornalley PJ, Langborg A, Minhas HS (1999) Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J 344:109-116 10.1042/0264-6021:3440109
41. Thornalley PJ (2003) Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts. Arch Biochem Biophys 419:31-40 10.1016/j.abb.2003.08.013
42. Thornalley PJ (1988) Modification of the glyoxalase system in human red blood cells by glucose in vitro. Biochem J 254:751-755 3196289
43. Nagao M, Fujita Y, Sugimura T, Kosuge T (1986) Methylglyoxal in beverages and foods its mutagenicity and carcinogenicity. IARC Sci Publ 70:283-291 3539787
44. Hayashi T, Shibamoto T (1985) Analysis of methylglyoxal in foods and beverages. J Agric Food Chem 33:1090-1093 10.1021/jf00066a018
45. Mortier S, Faict D, Schalkwijk CG, Lameire NH, De Vriese AS (2004) Long-term exposure to new peritoneal dialysis solutions: Effects on the peritoneal membrane. Kidney Int 66:1257-1265 10.1111/ j.1523-1755.2004.00879.x
46. Oste RE, Miller R, Sjostrom H, Noren O (1987) Effect of Maillard reaction products on protein digestion - studies on pure compounds. J Agric Food Chem 35:938-942 10.1021/jf00078a020
47. Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S (2002) Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346:802-810 10.1056/NEJMoa012578
48. Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR, UK Prospective Diabetes Study Group (2003) Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int 63:225-252 10.1046/j.1523-1755.2003.00712.x
49. Babaei-Jadidi R, Karachalias N, Ahmed N, Battah S, Thornalley PJ (2003) Prevention of incipient diabetic nephropathy by high dose thiamine and Benfotiamine. Diabetes 52:2110-2120 12882930
50. Litwin M, Wuhl E, Jourdan C, Trelewicz J, Niemirska A, Fahr K, Jobs K, Grenda R, Wawer ZT, Rajszys P, Troger J, Mehls O, Schaefer F (2005) Altered morphologic properties of large arteries in children with chronic renal failure and after renal transplantation. J Am Soc Nephrol 16:1494-1500 10.1681/ASN.2004110932
51. Chavers BM, Li S, Collins AJ, Herzog CA (2002) Cardiovascular disease in pediatric chronic dialysis patients. Kidney Int 62:648-653 10.1046/ j.1523-1755.2002.00472.x
52. Misselwitz J, Franke S, Kauf E, John U, Stein G (2002) Advanced glycation end products in children with chronic renal failure and type 1 diabetes. Pediatr Nephrol 17:316-321 10.1007/s00467-001-0815-9
53. Bayazit AK, Vogt BA, Dell KM, Davis ID, Noyan A, Anarat A, Avner ED, Erhard P, Weiss MF (2003) Effect of the peritoneal dialysis prescription on pentosidine in children. Pediatr Nephrol 18:1049-1054 10.1007/ s00467-003-1230-1
54. Sebekova K, Podracka L, Heidland A, Schinzel R (2001) Enhanced plasma levels of advanced glycation end products (AGE) and pro-inflammatory cytokines in children/adolescents with chronic renal insufficiency and after renal replacement therapy by dialysis and transplantation - are they inter-related? Clin Nephrol 56:S21-S26 11770807
55. Flynn JT (2002) Choice of dialysis modality for management of pediatric acute renal failure. Pediatr Nephrol 17:61-69 10.1007/s004670200011
56. Leonard MB, Donaldson LA, Ho M, Geary DF (2003) A prospective cohort study of incident maintenance dialysis in children: An NAPRTC study. Kidney Int 63:744-755 10.1046/j.1523-1755.2003.00788.x
57. Schroder CH (2001) The choice of dialysis solutions in pediatric chronic peritoneal dialysis: Guidelines by an ad hoc European committee. Perit Dial Int 21:568-574 11783765
58. Deguchi T, Kusuhara H, Takadate A, Endou H, Otagiri M, Sugiyama Y (2004) Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int 65:162-174 10.1111/j.1523-1755.2004.00354.x
59. Mann GE, Yudilevich DL, Sobrevia L (2003) Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 83:183-252 12506130
60. Deuther-Conrad W, Franke S, Sommer M, Henle T, Stein G (2001) Differences in the modulating potential of advanced glycation (AGE) peptides versus AGE proteins. Kidney Int 59:S63-S66 10.1046/ j.1523-1755.2001.07815.x
61. Yoshihara K, Okumura T, Yoshida T, Beppu M (2001) Inhibitory effect of peptide-free forms of advanced glycation end products on the proliferation and extracellular matrix protein production of cultured cells. J Health Sci 47:296-301 10.1248/jhs.47.296
62. Thornalley PJ (1998) Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs. Cell Mol Biol 44:1013-1023 9846883
63. Thornalley PJ (2004) Glycation, receptor-mediated cell activation and vascular complications of diabetes. Diabetes Vasc Dis Res 1:21-22
64. Kuzuya M, Asai T, Kanda S, Maeda K, Cheng XW, Iguchi A (2001) Glycation cross-links inhibit matrix metalloproteinase-2 activation in vascular smooth muscle cells cultured on collagen lattice. Diabetologia 44:436 10.1007/s001250051640
65. Lindsay RM, Nesrallah G, Suri R, Garg A, Moist L (2004) Is more frequent hemodialysis beneficial and what is the evidence? Curr Opinion Nephrol Hypertens 13:631-635 10.1097/00041552-200411000-00008