Use of cell therapy as a means of targeting chemotherapy to inoperable pancreatic cancer

Acta Biochimica Polonica

Volumn 52, Issue 3, 2005, Pages 601-607

  Günzburg, Walter H ^a   Salmons, Brian ^b  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b Austrianova Biomanufacturing Company   (Austria)

Author keywords

Cell therapy; Chemotherapy; Cytochrome P450; Encapsulated cells; Genetically modified cells; Pancreatic cancer

Indexed keywords

ANIMALIA;

EID: 27644435839     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.2005_3420     Document Type: Conference Paper

References (46)

1. Ajani JA, Abbruzzese JL, Goudeau P, Faintuch JS, Yeomans AC, Boman BM, Nicaise C, Levin B (1988) Ifosfamide and mesna: marginally active in patients with advanced carcinoma of the pancreas. J Clin Oncol 6: 1703-1707.
2. Block A, Chen SH, Kosai K, Finegold M, Woo SL (1997) Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors. Pancreas 15: 25-34.
3. Burris HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD, von Hoof DD (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreatic cancer: a randomized trial. J Clin Oncol 15: 2403-2413.
4. Carmichael J, Fink U, Russell RCG, Spittle MF, Harris AL, Spiessi G, Blatter J (1996) Phase II study of gemcitabine in patients with advanced pancreatic cancer. Br J Cancer 73: 101-105.
5. Carrio M, Romagosa A, Mercade E, Mazo A, Nadal M, Gomez-Foix A-M, Fillat, C (1999) Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene. Gene Ther 6: 547-553.
6. Casper ES, Green MR, Kelsen DP, Heelan RT, Brown TD, Flombaum CD, Trochanowski B, Tarassoff PG (1994) Phase II trial of gemcitabine (2,2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs 12: 29-34.
7. Cerny T, Martinelli G, Goldhirsch A, Terrier F, Joss R, Fey MF, Brunner KW, Kupfer A (1991) Continuous 5-day infusion of ifosfamide with mesna in inoperable pancreatic cancer patients: a phase II study. J Cancer Res Clin Oncol 117: S135-S138.
8. Chen L, Waxman DJ (1995) Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy. Cancer Res 55: 581-589.
9. Dautzenberg H, Schuldt U, Grasnick G, Karle P, Müller P, Löhr M, Pelegrin M, Piechaczyk M, von Rombs K, Günzburg WH, Salmons B, Saller RM (1999) Development of cellulose sulphate based polyelectrolyte complex microcapsules for medical applications. Ann NY Acad Sci USA 875: 46-63.
10. Diaz-Rubio E (2004) New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers. Oncologist 9: 282-294.
11. Dondelinger R (1999) Advances in abdominal interventional radiology. Lancet 353: SI15-SI18.
12. Gad-el-Mawla N (1986) Ifosfamide in advanced pancreatic cancer. A 5-year experience. Cancer Chemother Pharmacol 18 (Suppl 2): 55-56.
13. Gad-el-Mawla N, Ziegler JL (1981) Ifosfamide treatment of pancreatic cancer. Cancer Treat Rep 65: 357-358.
14. Günzburg WH, Lohr M, Salmons B (2002) Novel treatments and therapies in development for pancreatic cancer. Expert Opin Investig Drugs 11: 769-786.
15. Haack K, Linnebacher M, Eisold S, Zoller M, von Knebel Doeberitz M, Gebert J (2000) Induction of protective immunity against syngeneic rat cancer cells by expression of the cytosine deaminase suicide gene. Cancer Gene Ther 7: 1357-1364.
16. Hauser O, Prieschl-Grassauer E, Salmons B (2004) Encapsulated, genetically modified cells producing in vivo therapeutics. Curr Opin Mol Ther 6: 412-420.
17. Hlavaty J, Portsmouth D, Stracke A, Salmons B, Günzburg WH, Renner M (2004a) Effects of sequences of prokaryotic origin on titre and transgene expression in retroviral vectors.
18. Hlavaty J, Stracke A, Klein D, Salmons B, Günzburg WH, Renner M (2004b) Multiple modifications allow high titer, tissue-specific retroviral vector production. J Virol 78: 1384-1392.
19. Howard BD, Boenicke L, Scniewind B, Henne-Bruns D, Kalthoff H (2000) Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir. Cancer Gene Ther 7: 927-938.
20. Kammertöns T, Gelbmann W, Karle P, Saller R, Salmons B, Günzburg WH, Uckert W (2000) Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine. Cancer Gene Ther 7: 629-636.
21. Kanyama H, Tomita N, Yamano T, Aihara T, Miyoshi Y, Ohue M, Sekimoto M, Sakita I, Tamaki Y, Kaneda Y, Senter PD, Monden M (2001) Usefulness of repeated direct intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy. Cancer Res 61: 14-18.
22. Karle P, Müller P, Renz R, Jesnowski R, Saller RM, von Rombs K, Nizze H, Liebe S, Günzburg WH, Salmons B, Löhr M (1998) Intratumour injection of encapsulated cells producing an ifosfamide activating cytochrome P450 for targeted chemotherapy. Adv Exp Med Biol 451: 97-106.
23. Karle P, Renner M, Salmons B, Günzburg WH (2001) Necrotic, rather than apoptotic, cell death caused by cytochrome P450 activated ifosfamide. Cancer Gene Ther 8: 220-230.
24. Keizer HJ, Ouwerkerk J, Welvaart K, van der Velde CJH, Cleton FJ (1995) Ifosfamide treatment as a 10-day continuous intravenous infusion. J Cancer Res Clin Oncol 121: 297-302.
25. Kröger JC, Bergmeister H, Hoffmeyer A, Ceijna M, Karle P, Saller R, Schwendenwein I, von Rombs K, Liebe S, Günzburg WH, Salmons B, Hauenstein K-H, Losert U, Löhr M (1999) Intra-arterial instillation of microencapsulated cells in the pancreatic arteries in pig. Ann NY Acad Sci USA 880: 374-378.
26. Kurowski V, Wagner T (1993) Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy. Cancer Chemother Pharmacol 33: 36-42.
27. Loehrer PJ, Williams SD, Einhorn LH, Ansari R (1985) Ifosfamide: an active drug in the treatment of adenocarcinoma of the pancreas. J Clin Oncol 3: 367-372.
28. Löhr M, Müller P, Karle P, Stange J, Mitzner S, Jesnowski R, Nizze H, Nebe B, Liebe S, Salmons B, Günzburg WH (1998) Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. Gene Therapy 5: 1070-1078.
29. Löhr JM, Bago ZT, Bergmeister H, Ceijnka M, Freund M, Gelbmann W, Günzburg WH, Jesnowski R, Hain J, Hauenstein K, Henninger W, Hoffmeyer A, Karle P, Kroger J-C, Kundt G, Liebe S, Losert U, Müller P, Probst A, Püschel K, Renner M, Renz R, Saller R, Salmons B, Schuh M, Schwendenwein I, von Rombs K, Wagner T, Walter I (1999) Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced stage pancreatic carcinoma: a phase I/II study. J Mol Med 77: 393-398.
30. Lohr M, Hoffmeyer A, Kroger J-C, Freund M, Hain J, Holle A, Karle P, Knofel WT, Liebe S, Muller P, Nizze H, Renner M, Saller RM, Wagner T, Hauenstein K, Gunzburg WH, Salmons B (2001) Microencapsulated, cellmediated treatment of inoperable pancreatic carcinoma. Lancet 357: 1591-1592.
31. Löhr M, Saller RM, Salmons B, Gunzburg WH (2002) Microencapsulation of genetically engineered cells for cancer therapy. Methods Enzymol 346: 603-618.
32. Löhr JM, Kröger J-C, Hoffmeyer A, Benz S, Müller P, Saller R, Nizze H, Klöppel G, Bergmeister H, Bago Z, Günzburg WH, Karle P, Obermaier R, Probst A, Renner M, Salmons B, Schwendenwein I, von Rombs K, Wiessner R, Losert U, Wagner T, Hauenstein K (2003) Intra-arterial instillation of microencapsulated, ifosfamide activating cells in the pig pancreas for chemotherapeutic targeting. Pancreatology 3: 55-63.
33. Lohr M, Hoffmeyer A, Kroger J-C, Freund M, Gunzburg WH, Hain J, Holle A, Knofel WT, Liebe S, Muller P, Nizze H, Renner M, Saller RM, Salmons B, Wagner T, Hauenstein K (2003) Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial. Cancer Therapy 1: 121-131.
34. Makinen K, Loimas S, Wahlfors J, Alhava E, Janne J (2000) Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer. J Gene Med 2: 361-367.
35. McKeown SR, Ward C, Robson T (2004) Gene-directed enzyme prodrug therapy: a current assessment. Curr Opin Mol Ther 6: 421-435.
36. Rieger J, Durka S, Streffer J, Dichgans J, Weller M (1999) Gemcitabine cytotoxicity of human malignant glioma cells: modulation by antioxidants, Bcl-2 and dexamethasone. Eur J Pharmacol 365: 301-308.
37. Sailer RM, Indraccolo S, Coppola V, Esposito G, Stange J, Mitzner S, Heinzmann U, Amadori A, Salmons B, Gunzburg WH (2002) Encapsulated cells producing retroviral vectors for in vivo gene transfer. J Gene Med 4: 150-160.
38. Salmons B, Gunzburg WH (1993) Targeting of retroviral vectors for gene therapy. Human Gene Therapy 4: 129-141.
39. Shiau A-L, Yang H-M, Wu P, Wu C-L (1998) Provision of postive and negative selections in retroviral vectors containing the cytosine deaminase gene. Gene Therapy 5: 1571-1574.
40. Storniolo AM, Enas NH, Brown CA, Voi M, Rothenberg ML, Schilsky R (1999) An investigational new drug treatment program for patients with gemcitabine: results for over 3000 patients with pancreatic carcinoma. Cancer 85: 1261-1268.
41. Talamonti M, Tellez C, Benson A (1998) Local-regional therapy for metastatic liver tumors. Cancer Treat Res. 98: 172-199.
42. Trinchet JC (1995) A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med 332: 1256-1261.
43. Uckert W, Salmons B, Beltinger C, Günzburg WH, Kammertöns T (2003) Combination suicide gene therapy. Methods Mol Med 90: 345-352.
44. Wei MX, Tamiya T, Chase M, Boviatsis EJ, Chang TKH, Kowall NW, Hochberg FH, Waxman DJ, Breakefield XO, Chiocca EA (1994) Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Human Gene Therapy 5: 969-978.
45. Wils JA, Kok T, Wagener DJT, Francois E, Selleslags J, Duez N (1993) Phase II trial with ifosfamide in pancreatic cancer. Eur J Cancer 29A: 290.
46. Zheng X, Johansson M, Karlsson A (2000) Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase. J Biol Chem 275: 39125-39129.