NMR assignments of tryptophan residue in apo and holo LBD-rVDR

Proteins: Structure, Function and Genetics

Volumn 61, Issue 3, 2005, Pages 461-467

  Sicinska, Wanda ^a,b   Westler, William M ^a   DeLuca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Poland)

Author keywords

Nuclear receptors; Orphan receptors; Protein ligand interactions; Steroid hormone receptors; Transcription factors

Indexed keywords

APO LBD RVDR PROTEIN; CALCIUM; HOLO LBD RVDR PROTEIN; LIGAND; TRYPTOPHAN; TRYPTOPHAN 282; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR LIGAND;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; QUANTUM MECHANICS; RAT; RECEPTOR BINDING; SIGNAL DETECTION; SINGLE QUANTUM CORRELATION SPECTROSCOPY;

ANIMALS; APOPROTEINS; BINDING SITES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; RATS; RECEPTORS, CALCITRIOL; TRYPTOPHAN; VITAMIN D;

ANIMALIA;

EID: 27544439435     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.20625     Document Type: Article

References (49)

1. Bouillon R, Okamura WH, Norman AW. Structure-function relationships in the vitamin D endocrine system. Endocr Rev 1995;16: 200-257.
2. DeLuca HF, Zierold C. Mechanism and functions of vitamin D. NutrRev 1998;56:S4-S10.
3. Yamada S, Shimizu M, Yamamoto K. Structure-function relationships of vitamin D including ligand recognition by the vitamin D receptor. Med Res Rev 2003;23:89-115.
4. Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 2003;23:117-145.
5. 3 receptor for the partial agonism of carboxylic ester antagonists. J Mol Biol 2002;315:229-238.
6. Issa LL, Leong GM, Sutherland RL, Eisman JA. Vitamin D analogue-specific recruitment of vitamin D receptor coactivators. J Bone Miner Res 2002;17:879-890.
7. Choi M, Yamamoto K, Itoh T, Makishima M, Mangelsdorf DJ, Moras D, DeLuca HF, Yamada S. Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis. Chem and Biol 2003;10:261-270.
8. 3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts. J Biol Chem 2003;278:31756-31765.
9. 3 receptor by interaction with co-repressors and co-activators. J Mol Biol 2000;304:793-801.
10. Yamamoto K, Ooizumi H, Umesono K, Verstuyf A, Bouillon R, DeLuca HF, Shinki T, Suda T, Yamada S. Three-dimensional structure-function relationship of vitamin D: side chain location and various activities. Bioorg Med Chem Lett 1999;9:1041-1046.
11. DeLuca HF, Sicinski RR, Gowlugari S, Plum LA, Clagett-Dame M. 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol and its uses. US Patent 2002;6,440,953.
12. 3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues. J Med Chem 1998;41:4662-4674.
13. Sicinski RR, Rotkiewicz P, Kolinski A, Sicinska W, Prahl JM, Smith CM, DeLuca HF. 2-Ethyl and 2-ethylidene analogues of 1α,25-dihydroxy-19- norvitamin D3: synthesis, conformational analysis, biological activities, and docking to the modeled rVDR ligand binding domain. J Med Chem 2002;45:3366-3380.
14. 3 selectively induces bone formation. Proc Natl Acad Sci USA 2002;99: 13487-13491.
15. 3 analogues. Bioorg Med Chem Lett 2000;10:1129-1132.
16. Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell 2000;5:173-179.
17. Tocchini-Valentini G, Rochel N, Wurtz JM, Mitschler A, Moras D. Crystal structures of the vitamin D receptor complexed to super-agonist 20-epi ligands. Proc Natl Acad Sci USA 2001;98:5491-5496.
18. 3 hormone analogs and an LXXLL-containing coactivator peptide. Biochem 2004;43:4101-4110.
19. Okamura WH, Do S, Kim H, Jeganathan S, Vu T, Zhu GD, Norman AW. Conformationally restricted mimics of vitamin D rotamers. Steroids 2001;66:239-247.
20. Suwinska K, Kutner A. Crystal and molecular structure of 1,25-dihydroxycholecalciferol. Acta Cryst 1996;B52:550-554.
21. Vaisanen S, Ryhanen S, Saarela JTA, Perakyla M, Andersin T, Maenpaa PH. Structurally and functionally important amino acids of the agonistic conformation of the human vitamin D receptor. Mol Pharm 2002;62:788-794.
22. Nguyen TM, Adiceam P, Kottler ML, Guillozo H, Rizk-Rabin M, Brouillard F, Lagier P, Palix C, Gamier JM, Garabedian M. Tryptophan missense mutation in the ligand-binding domain of the vitamin D receptor causes severe resistance to 1,25-dihydroxy vitamin D. J Bone Miner Res 2002;17:1728-1737.
23. 3 receptor. J Biol Chem 1996;271,2012-2017.
24. Strugnell SA, Hill JJ, McCaslin DR, Wiefling BA, Royer CA, DeLuca HF. Bacterial expression and characterization of the ligand binding domain of the vitamin D receptor. Arch Biochem Biophys 1999;364:42-52.
25. 3 receptor. Biochem J 1997;327:561-568.
26. Strugnell SA, DeLuca HF. The vitamin D receptor-structure and transcriptional activation. Proc Soc Exp Biol Med 1997;215:223-228.
27. Solomon C, Macoritto M, Gao XL, White JH, Kremer R. The unique tryptophan residue of the vitamin D receptor is critical for ligand binding and transcriptional activation. J Bone Miner Res 2001;16:39-45.
28. th Workshop on Vitamin D in J Steroid Biochem Mol Biol 2004;89-90:107-110.
29. Mohammadi F, Prentice GA, Merril AR. Protein-protein interaction using tryptophan analogues: novel spectroscopic probes for toxin-elongation factor-2 interactions. Biochem 2001;40:10273-10283.
30. Cheng H, Westler WM, Xia B, Oh BH, Markley JL. Protein expression, selective isotope labeling, and analysis of hyperfineshifted NMR signals of anabaena 7120 vegetative [2Fe-2S] ferrodoxin. Arch Biochem Biophys 1995;316:619-634.
31. 3: Interaction with distinct receptor domains. Biochem 1986;25:4523-4534.
32. Gallagher SR, One-dimensional electrophoresis using nondenaturating conditions. In: Taylor GP, editor. Current protocols in protein science. Somerset, NY: Wiley, 1995-2000. p 10.3.
33. Mori S, Abeygunawardana C, Johnson MO, Vanzijl PCM. Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation. J Magn Reson Series B 1995;108:94-8.
34. Markley J, Bax A, Arata Y, Hilbers CW, Kaptein R, Sykes BD, Wright PE, Wuthrich K. Recommendations for the presentation of NMR structures of proteins and nucleic acids. Pure Appl Chem 1998;70:117-142.
35. Wider G, Wuthrich K. NMR spectroscopy of large molecules and multinuclear assemblies in solution. Curr Opin Struct Biol 1999;9: 594-601.
36. Markley JL, Kainosho M. Stable isotope labelling and resonance assignments in larger proteins. In: Roberts GCK, editor. NMR of macromolecules. A practical approach. Oxford: Oxford University Press, 1993. p 101-152.
37. Gunther H. NMR Spectroscopy. New York: Wiley; 1980. 75 p.
38. Melander W, Horvath C. Salt effects on hydrophobic interactions in precipitation and chromatography of proteins: an interpretation of the lyotropic series. Arch Bioch Biophys 1977;183:200-215.
39. Symons MCR. Water structure and reactivity. Acc Chem Res 1981;14:179-187.
40. Witanowski M, Sicinska W, Grabowski Z, Webb GA. Pyrrole and N-methylpyrrole as models for solvent polarity and solute-to-solvent hydrogen bonding effects on nitrogen NMR shielding. J Magn Reson 1993;104A:310-314.
41. Witanowski M, Stefaniak L, Webb GA. Nitrogen NMR spectroscopy. In: Webb GA, editor. Annual reports on NMR spectroscopy, vol 25. San Diego: Academic Press; 1993. p 225.
42. Witanowski M, Stefaniak L, Webb GA. Nitrogen NMR spectroscopy. In: Webb GA, editor. Annual reports on NMR spectroscopy, vol 25. San Diego. Academic Press; 1993. p 50.
43. Lee W, Noy N. Interactions of RXR with coactivators are differentially mediated by helix 11 of receptor's ligand binding domain. Biochem 2001;41:2500-2508.
44. Barry JB, Leong GM, Church WB, Issa LL, Eisman JA, Gardiner EM. Interactions of SKIP/NCoA-62, TFIIB, and Retinoid X receptor with vitamin D receptor helix H10 residues. J Biol Chem 2003;278:8224-8228.
45. 3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. J Bone Miner Res 2002;17:2196-2205.
46. 2-and COOH-terminal interaction inhibits p 160 coactivator recruitment by activation function 2. J Biol Chem 2001;276:42293-42301.
47. 3 strongly modulates the affinity for the vitamin D receptor (VDR). Org Lett 2003;5:2291-2293.
48. 3. J Med Chem 1995;39: 4497-4506.
49. 3 compounds with modified side chain: 26,27-dihomo- and 26,27-dimethylene analogs in 20S-series. Steroids 2002;67:247-256.