Conformationally restricted mimics of vitamin D rotamers

Steroids

Volumn 66, Issue 3-5, 2001, Pages 239-247

  Okamura, William H ^a   Do, Steven ^a   Kim, Hoim ^a   Jeganathan, S ^a   Vu, Thong ^a   Zhu, Gui Dong ^a   Norman, Anthony W ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ansa steroids; Suprasterols; Vitamin D

Indexed keywords

ANSA STEROID; CALCITRIOL DERIVATIVE; COLECALCIFEROL; SUPRASTEROL; UNCLASSIFIED DRUG; VINYLALLENE; VITAMIN D; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

CHEMICAL MODIFICATION; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG STRUCTURE; ENERGY; ISOMER; LIGAND BINDING; METABOLITE; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; ROTAMER; STRUCTURE ACTIVITY RELATION; VITAMIN D METABOLISM; X RAY CRYSTALLOGRAPHY;

ANIMALS; CALCITRIOL; HUMANS; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035342732     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00147-1     Document Type: Conference Paper

References (39)

1. Structure-function relationships in the vitamin D endocrine system
2. Chemistry and Design; Structural biology of vitamin D action
3. Synthesis of vitamin D (calciferol)
4. The conservation of orbital symmetry
5. 3
6. Crystal and molecular-structure of 1,25-dihydroxycholecalciferol
7. 3 monohydrate; A stereo-chemical analysis of vitamin D molecules
8. 3 by high resolution proton magnetic resonance spectroscopy
9. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand
10. Large-scale expression and purification of the human vitamin D receptor and its ligand-binding domain for structural studies
11. 3
12. 3 by nuclear magnetic resonance
13. Chemistry and conformation of vitamin D molecules
14. Conformational analysis of model compounds of vitamin D by theoretical calculations
15. Planar s-cis-1,3-butadiene
16. 3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis nor 6-s-trans locked analogs are preferred for genomic biological responses
17. Ansa-steroids
18. Ansa-seco-steroide
19. 3 and its analogs
20. Vitamin D, its metabolites and analogs; a review of the structural requirements for biological activity
21. Vitamin D, example and challenge
22. Über einige krystallisierte Bestrahlungsprodukte aus Ergosterin und Dehydro-ergosterin
23. Photochemical transformations. IX. Total structure of suprasterol II
24. Investigations on sterols. VIII some hitherto unknown irradiation products of ergosterol
25. The crystal structure of suprasterol II
26. 2)
27. 3 photochemistry
28. 3
29. 3
30. Elucidation of the solution conformation of the A ring in vitamin D using proton coupling constants and a shift reagent
31. 3
32. Mechanism of the photochemical transformation of a 1,3,5-hexatriene to a bicyclo[3.1.0]hex-2-ene
33. Rearrangement of vinylallenes to 1-hydroxylated vitamin D model systems lacking the D-ring and side chain
34. The vinylallene approach to the 1-hydroxyvitamin D system. New sigmatropic reactions in the vitamin D series