Fasting and post-methionine loading concentrations of homocysteine, vitamin B2, and vitamin B6 in patients on antiepileptic drugs

Clinical Chemistry

Volumn 49, Issue 6, 2003, Pages 1005-1008

  Apeland, Terje ^a   Mansoor, Mohammad Azam ^a   Pentieva, Kristina ^b   McNulty, Helene ^b   Strandjord, Roald E ^a  

^a STAVANGER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTICONVULSIVE AGENT; CARBAMAZEPINE; HOMOCYSTEINE; METHIONINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; PYRIDOXINE DERIVATIVE; RIBOFLAVIN; VALPROIC ACID;

ADULT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; EPILEPSY; FEMALE; FOLATE METABOLISM; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; METHIONINE LOADING TEST; METHYLATION; NON INVASIVE MEASUREMENT; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADULT; ANTICONVULSANTS; FASTING; FEMALE; HOMOCYSTEINE; HUMANS; MALE; METHIONINE; RIBOFLAVIN; VITAMIN B 6;

EID: 0038359296     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/49.6.1005     Document Type: Article

References (21)

1. Apeland T, Mansoor MA, Strandjord RE. Antiepileptic drugs as independent predictors of plasma total homocysteine levels. Epilepsy Res 2001;47:27-35.
2. Apeland T, Mansoor MA, Strandjord RE, Vefring H, Kristensen O. Folate, homocysteine and methionine loading in patients on carbamazepine. Acta Neurol Scand 2001;103:294-9.
3. Schwaninger M, Ringleb P, Winter R, Kohl B, Fiehn W, Rieser PA, et al. Elevated plasma concentrations of homocysteine in antiepileptic drug treatment. Epilepsia 1999;40:345-50.
4. Verrotti A, Pascarella R, Trotta D, Giuva T, Morgese G, Chiarelli F. Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine. Epilepsy Res 2000;41:253-7.
5. Lindhout D, Omtzigt JG. Pregnancy and the risk of teratogenicity. Epilepsia 1992;33:S41-8.
6. Reynolds EH. Chronic antiepileptic toxicity: a review. Epilepsia 1975;16:319-52.
7. Apeland T, Mansoor MA, Pentieva K, McNulty H, Seljeflot I, Strandjord RE. The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs. Epilepsy Res 2002;51:237-47.
8. Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Hemost 2000;26:219-25.
9. Bates CJ. Riboflavin. In: Callabero B. ed. Encyclopedia of human nutrition. London: Academic Press, 1999:1722-30.
10. Krause KH, Bonjour JP, Berlit P, Kynast G, Schmidt-Gayk H, Schellenberg B. Effect of long-term treatment with antiepileptic drugs on the vitamin status. Drug Nutr Interact 1988;5:317-43.
11. Lewis JA, Baer MT, Laufer MA. Letter: Urinary riboflavin and creatinine excretion in children treated with anticonvulsant drugs. Am J Dis Child 1975;129:394.
12. Sardharwalla IB, Fowler B, Robins AJ, Komrower GM. Detection of heterozygotes for homocystinuria. Study of sulphur-containing amino acids in plasma and urine after L-methionine loading. Arch Dis Child 1974;49:553-9.
13. Apeland T, Mansoor MA, Strandjord RE, Kristensen O. Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. Acta Neurol Scand 2000;101:217-23.
14. Mansoor MA, Svardal AM, Ueland PM. Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma. Anal Biochem 1992;200:218-29.
15. Zempleni J. Determination of riboflavin and flavocoenzymes in human blood plasma by high-performance liquid chromatography. Ann Nutr Metab 1995;39:224-6.
16. Bates CJ, Pentieva KD, Matthews N, Macdonald A. A simple, sensitive and reproducible assay for pyridoxal 5′-phosphate and 4-pyridoxic acid in human plasma. Clin Chim Acta 1999;280:101-11.
17. Hustad S, McKinley MC, McNulty H, Schneede J, Strain JJ, Scott JM, et al. Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation. Clin Chem 2002;48:1571-7.
18. Hamajima S, Ono S, Hirano H, Obara K. Induction of the FAD synthetase system in rat liver by phenobarbital administration. Int J Vitam Nutr Res 1979;49:59-63.
19. Bottiglieri T, Crellin R, Reynolds EH. Folate and neuropsychiatry. In: Baily LB, ed. Folate in health and disease, 1st ed. New York: Marcel Dekker, 1995:435-62.
20. 6 requirements of humans. Ann N Y Acad Sci 1990;585:76-85.
21. Kretsch MJ, Sauberlich HE, Newbrun E. Electroencephalographic changes and periodontal status during short-term vitamin B-6 depletion of young, nonpregnant women. Am J Clin Nutr 1991;53:1266-74.