Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: A potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood

Developmental Medicine and Child Neurology

Volumn 43, Issue 4, 2001, Pages 220-225

  Prengler, Mara ^a   Sturt, Natalie ^a   Krywawych, Steve ^a   Surtees, Robert ^a   Liesner, Raina ^a   Kirkham, Fenella ^b  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADOLESCENT; ALLELE; AMINO ACID BLOOD LEVEL; ARTICLE; CEREBROVASCULAR DISEASE; CHILD; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HYPERHOMOCYSTEINEMIA; INFANT; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; STROKE; TRANSIENT ISCHEMIC ATTACK;

ADOLESCENT; ALLELES; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISORDERS; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HOMOCYSTEINE; HOMOZYGOTE; HUMANS; INFANT; ISCHEMIC ATTACK, TRANSIENT; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; RECURRENCE; RISK FACTORS; TEMPERATURE;

EID: 0035055560     PISSN: 00121622     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-8749.2001.tb00193.x     Document Type: Article

References (28)

1. Factor V1691 G-A, prothrombin 20210 G-A and methylene tetrahydrofolate reductase 677 C-T variants in Turkish children with cerebral infarct
2. The mutation Ala 677 → Val in the methyllene tetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
3. Factor V Leiden (G1691A), the prothrombin 3′-unstranslated region variant (G20210A) and thermolabile methylenetetrahydrofolate reductase (C677T): A single genetic test genotypes all three loci. Determination of frequencies in the S. Wales population of the UK
4. 677C→T polymorphism of the 5, 10 methylenetetrahydrofolate reductase gene, mild hyperhomocysteinemia, and vitamin status in children with stroke
5. Prothrombotic disorders in infants and children with cerebral thromboembolism
6. Elevated total plasma homocysteine and 677C→T mutation of the 5, 10-methylenetetrahydrofolate reductase gene in thrombotic vascular disease
7. Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke
8. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
9. Inherited prothrombotic states and ischaemic stroke in childhood
10. The effect of folic acid fortification on plasma folate and total homocysteine concentrations
11. Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease
12. The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T)
13. Coexistence of hereditary homocystinuria and factor V Leiden: Effect on thrombosis
14. A common polymorphism in the methylene tetrahydrofolate reductase gene, homocysteine and ischaemic cerebrovascular disease
15. Nutritional ecogenetics: Homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid
16. Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin and methylenetetrahydrofolate reductase are risk factors of spontaneous ischaemic stroke in childhood
17. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis
18. Angiographic findings of ischemic stroke in children
19. Can lowering homocysteine levels reduce cardiovascular risk?
20. Abnormalities of vascular function in hyperhomocysteinaemia: Relationship to atherothrombotic disease
21. Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine β-synthase deficiency: The effect of treatment
22. Does the polymorphism 677C-T of the 5,10-methylenetetrahydrofolate reductase gene contribute to homocysteine-related vascular disease?
23. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum
24. Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease, and drug therapy
25. Hyperhomocysteinemia: A risk factor for ischemic stroke in children
26. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: A randomised, placebo-controlled trial
27. Homocysteine and atherothrombosis