메뉴 건너뛰기




Volumn 106, Issue 8, 2005, Pages 2761-2768

A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; THROMBOMODULIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 27144551976     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2004-12-4623     Document Type: Article
Times cited : (25)

References (45)
  • 1
    • 2942705827 scopus 로고    scopus 로고
    • Novel functions of thrombomodulin in inflammation
    • Van de Wouwer M, Conway EM. Novel functions of thrombomodulin in inflammation. Crit Care Med. 2004;32:S254-S261.
    • (2004) Crit Care Med , vol.32
    • Van De Wouwer, M.1    Conway, E.M.2
  • 2
    • 0141819138 scopus 로고    scopus 로고
    • The protein C pathway
    • Esmon CT. The protein C pathway. Chest. 2003;124:26S-32S.
    • (2003) Chest , vol.124
    • Esmon, C.T.1
  • 3
    • 0026671606 scopus 로고
    • The anticoagulants protein C and protein S display potent antiinflammatory and immunosuppressive effects relevant to transplant biology and therapy
    • Hancock WW, Tsuchida A, Hau H, Thomson NM, Salem HH. The anticoagulants protein C and protein S display potent antiinflammatory and immunosuppressive effects relevant to transplant biology and therapy. Transplant Proc. 1992;24:2302-2303.
    • (1992) Transplant Proc , vol.24 , pp. 2302-2303
    • Hancock, W.W.1    Tsuchida, A.2    Hau, H.3    Thomson, N.M.4    Salem, H.H.5
  • 4
    • 0027998013 scopus 로고
    • Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester
    • Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester. J Immunol. 1994;153:3664-3672.
    • (1994) J Immunol , vol.153 , pp. 3664-3672
    • Grey, S.T.1    Tsuchida, A.2    Hau, H.3    Orthner, C.L.4    Salem, H.H.5    Hancock, W.W.6
  • 5
    • 0028299926 scopus 로고
    • Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide
    • Grinnell BW, Hermann RB, Yan SB. Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. Glycobiology. 1994;4:221-225.
    • (1994) Glycobiology , vol.4 , pp. 221-225
    • Grinnell, B.W.1    Hermann, R.B.2    Yan, S.B.3
  • 6
    • 0034660464 scopus 로고    scopus 로고
    • Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation
    • Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood. 2000;95:3781-3787.
    • (2000) Blood , vol.95 , pp. 3781-3787
    • Mizutani, A.1    Okajima, K.2    Uchiba, M.3    Noguchi, T.4
  • 7
    • 0033866550 scopus 로고    scopus 로고
    • Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation
    • Hirose K, Okajima K, Taoka Y, et al. Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Ann Surg. 2000;232:272-280.
    • (2000) Ann Surg , vol.232 , pp. 272-280
    • Hirose, K.1    Okajima, K.2    Taoka, Y.3
  • 8
    • 0035806897 scopus 로고    scopus 로고
    • Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide
    • Isobe H, Okajima K, Uchiba M, et al. Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide. Circulation. 2001;104:1171-1175.
    • (2001) Circulation , vol.104 , pp. 1171-1175
    • Isobe, H.1    Okajima, K.2    Uchiba, M.3
  • 9
    • 0030909690 scopus 로고    scopus 로고
    • Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production
    • Murakami K, Okajima K, Uchiba M, et al. Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. Am J Physiol. 1997;272:L197-L202.
    • (1997) Am J Physiol , vol.272
    • Murakami, K.1    Okajima, K.2    Uchiba, M.3
  • 10
    • 12144291151 scopus 로고    scopus 로고
    • Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice
    • Yuda H, Adachi Y, Taguchi O, et al. Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice. Blood. 2004;103:2196-2204.
    • (2004) Blood , vol.103 , pp. 2196-2204
    • Yuda, H.1    Adachi, Y.2    Taguchi, O.3
  • 11
    • 0034955797 scopus 로고    scopus 로고
    • Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse
    • Yasui H, Gabazza EC, Tamaki S, et al. Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse. Am J Respir Crit Care Med. 2001;163:1660-1668.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1660-1668
    • Yasui, H.1    Gabazza, E.C.2    Tamaki, S.3
  • 12
    • 10244229104 scopus 로고    scopus 로고
    • Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis
    • Nick JA, Coldren CD, Geraci MW, et al. Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood. 2004;104:3878-3885.
    • (2004) Blood , vol.104 , pp. 3878-3885
    • Nick, J.A.1    Coldren, C.D.2    Geraci, M.W.3
  • 13
    • 0026646771 scopus 로고
    • Thrombomodulin is preferentially expressed in Balb/c lung microvessels
    • Ford VA, Stringer C, Kennel SJ. Thrombomodulin is preferentially expressed in Balb/c lung microvessels. J Biol Chem. 1992;267:5446-5450.
    • (1992) J Biol Chem , vol.267 , pp. 5446-5450
    • Ford, V.A.1    Stringer, C.2    Kennel, S.J.3
  • 14
    • 0032402132 scopus 로고    scopus 로고
    • Intravascular coagulation activation in a murine model of thrombomodulin deficiency: Effects of lesion size, age, and hypoxia on fibrin deposition
    • Healy AM, Hancock WW, Christie PD, Rayburn HB, Rosenberg RD. Intravascular coagulation activation in a murine model of thrombomodulin deficiency: effects of lesion size, age, and hypoxia on fibrin deposition. Blood. 1998;92:4188-4197.
    • (1998) Blood , vol.92 , pp. 4188-4197
    • Healy, A.M.1    Hancock, W.W.2    Christie, P.D.3    Rayburn, H.B.4    Rosenberg, R.D.5
  • 15
    • 1442308091 scopus 로고    scopus 로고
    • Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide
    • Rijneveld AW, Weijer S, Florquin S, et al. Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide. Blood. 2004;103:1702-1709.
    • (2004) Blood , vol.103 , pp. 1702-1709
    • Rijneveld, A.W.1    Weijer, S.2    Florquin, S.3
  • 16
    • 0032080409 scopus 로고    scopus 로고
    • A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state
    • Weiler-Guettler H, Christie PD, Beeler DL, et al. A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J Clin Invest. 1998;101:1983-1991.
    • (1998) J Clin Invest , vol.101 , pp. 1983-1991
    • Weiler-Guettler, H.1    Christie, P.D.2    Beeler, D.L.3
  • 17
    • 0037844355 scopus 로고    scopus 로고
    • Immune response to tuberculosis: Experimental animal models
    • Edinb
    • Kaufmann SH. Immune response to tuberculosis: experimental animal models. Tuberculosis (Edinb). 2003;83:107-111.
    • (2003) Tuberculosis , vol.83 , pp. 107-111
    • Kaufmann, S.H.1
  • 18
    • 0037297647 scopus 로고    scopus 로고
    • Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis
    • Peters W, Ernst JD. Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis. Microbes Infect. 2003;5:151-158.
    • (2003) Microbes Infect , vol.5 , pp. 151-158
    • Peters, W.1    Ernst, J.D.2
  • 19
    • 0028876697 scopus 로고
    • Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system
    • U S A
    • Healy AM, Rayburn HB, Rosenberg RD, Weiler H. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci U S A. 1995;92:850-854.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 850-854
    • Healy, A.M.1    Rayburn, H.B.2    Rosenberg, R.D.3    Weiler, H.4
  • 20
    • 0035313449 scopus 로고    scopus 로고
    • Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice
    • Leemans JC, Juffermans NP, Florquin S, et al. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J Immunol. 2001;166:4604-4611.
    • (2001) J Immunol , vol.166 , pp. 4604-4611
    • Leemans, J.C.1    Juffermans, N.P.2    Florquin, S.3
  • 21
    • 0037372993 scopus 로고    scopus 로고
    • CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis
    • Leemans JC, Florquin S, Heikens M, Pals ST, van der Neut R, Van Der Poll T. CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis. J Clin Invest. 2003;111:681-689.
    • (2003) J Clin Invest , vol.111 , pp. 681-689
    • Leemans, J.C.1    Florquin, S.2    Heikens, M.3    Pals, S.T.4    Van Der Neut, R.5    Van Der Poll, T.6
  • 22
    • 0042769821 scopus 로고    scopus 로고
    • Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis
    • Weijer S, Leemans JC, Florquin S, Shimizu T, Ishii S, van der Poll T. Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis. Immunology. 2003;109:552-556.
    • (2003) Immunology , vol.109 , pp. 552-556
    • Weijer, S.1    Leemans, J.C.2    Florquin, S.3    Shimizu, T.4    Ishii, S.5    Van Der Poll, T.6
  • 23
    • 0038115187 scopus 로고    scopus 로고
    • Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein C-deficient mice
    • Levi M, Dorffler-Melly J, Reitsma PH, et al. Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein C-deficient mice. Blood. 2003;101:4823-4827.
    • (2003) Blood , vol.101 , pp. 4823-4827
    • Levi, M.1    Dorffler-Melly, J.2    Reitsma, P.H.3
  • 24
    • 1542374453 scopus 로고    scopus 로고
    • Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice
    • Weijer S, Schoenmakers SH, Florquin S, et al. Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice. J Infect Dis. 2004;189:2308-2317.
    • (2004) J Infect Dis , vol.189 , pp. 2308-2317
    • Weijer, S.1    Schoenmakers, S.H.2    Florquin, S.3
  • 25
    • 10744227203 scopus 로고    scopus 로고
    • CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy
    • Rouschop KM, Sewnath ME, Claessen N, et al. CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy. J Am Soc Nephrol. 2004;15:674-686.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 674-686
    • Rouschop, K.M.1    Sewnath, M.E.2    Claessen, N.3
  • 26
    • 0035833529 scopus 로고    scopus 로고
    • Dysfunction of endothelial protein C activation in severe meningococcal sepsis
    • Faust SN, Levin M, Harrison OB, et al. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med. 2001;345:408-416.
    • (2001) N Engl J Med , vol.345 , pp. 408-416
    • Faust, S.N.1    Levin, M.2    Harrison, O.B.3
  • 27
    • 0036798545 scopus 로고    scopus 로고
    • Hemostatic changes in active pulmonary tuberculosis
    • Turken O, Kunter E, Sezer M, et al. Hemostatic changes in active pulmonary tuberculosis. Int J Tuberc Lung Dis. 2002;6:927-932.
    • (2002) Int J Tuberc Lung Dis , vol.6 , pp. 927-932
    • Turken, O.1    Kunter, E.2    Sezer, M.3
  • 28
    • 0025157260 scopus 로고
    • Disseminated intravascular coagulation in association with cavitary tuberculosis
    • Stein DS, Libertin CR. Disseminated intravascular coagulation in association with cavitary tuberculosis. South Med J. 1990;83:60-63.
    • (1990) South Med J , vol.83 , pp. 60-63
    • Stein, D.S.1    Libertin, C.R.2
  • 29
    • 0035495579 scopus 로고    scopus 로고
    • How can immunology contribute to the control of tuberculosis?
    • Kaufmann SH. How can immunology contribute to the control of tuberculosis? Nat Rev Immunol. 2001;1:20-30.
    • (2001) Nat Rev Immunol , vol.1 , pp. 20-30
    • Kaufmann, S.H.1
  • 30
    • 0035064072 scopus 로고    scopus 로고
    • Immunology of tuberculosis
    • Flynn JL, Chan J. Immunology of tuberculosis. Annu Rev Immunol. 2001;19:93-129.
    • (2001) Annu Rev Immunol , vol.19 , pp. 93-129
    • Flynn, J.L.1    Chan, J.2
  • 31
    • 0032509889 scopus 로고    scopus 로고
    • Chemokines: Chemotactic cytokines that mediate inflammation
    • Luster AD. Chemokines: chemotactic cytokines that mediate inflammation. N Engl J Med. 1998;338:436-445.
    • (1998) N Engl J Med , vol.338 , pp. 436-445
    • Luster, A.D.1
  • 32
    • 0031861489 scopus 로고    scopus 로고
    • Protein C anticoagulant system in patients with interstitial lung disease
    • Kobayashi H, Gabazza EC, Taguchi O, et al. Protein C anticoagulant system in patients with interstitial lung disease. Am J Respir Crit Care Med. 1998;157:1850-1854.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1850-1854
    • Kobayashi, H.1    Gabazza, E.C.2    Taguchi, O.3
  • 33
    • 0036719236 scopus 로고    scopus 로고
    • New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins
    • Esmon CT. New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins. J Exp Med. 2002;196:561-564.
    • (2002) J Exp Med , vol.196 , pp. 561-564
    • Esmon, C.T.1
  • 34
    • 0035572892 scopus 로고    scopus 로고
    • Characterization of a mouse model for thrombomodulin deficiency
    • Weiler H, Lindner V, Kerlin B, et al. Characterization of a mouse model for thrombomodulin deficiency. Arterioscler Thromb Vasc Biol. 2001;21:1531-1537.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1531-1537
    • Weiler, H.1    Lindner, V.2    Kerlin, B.3
  • 35
    • 0041844981 scopus 로고    scopus 로고
    • The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection
    • Sato J, Schorey J, Ploplis VA, Haalboom E, Krahule L, Castellino FJ. The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. Am J Pathol. 2003;163:517-531.
    • (2003) Am J Pathol , vol.163 , pp. 517-531
    • Sato, J.1    Schorey, J.2    Ploplis, V.A.3    Haalboom, E.4    Krahule, L.5    Castellino, F.J.6
  • 36
    • 0029819270 scopus 로고    scopus 로고
    • Recombinant thrombomodulin prevents endotoxin-induced lung injury in rats by inhibiting leukocyte activation
    • Uchiba M, Okajima K, Murakami K, Johno M, Okabe H, Takatsuki K. Recombinant thrombomodulin prevents endotoxin-induced lung injury in rats by inhibiting leukocyte activation. Am J Physiol. 1996;271:L470-L475.
    • (1996) Am J Physiol , vol.271
    • Uchiba, M.1    Okajima, K.2    Murakami, K.3    Johno, M.4    Okabe, H.5    Takatsuki, K.6
  • 37
    • 0028853552 scopus 로고
    • Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats
    • Uchiba M, Okajima K, Murakami K, Nawa K, Okabe H, Takatsuki K. Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats. Thromb Haemost. 1995;74:1265-1270.
    • (1995) Thromb Haemost , vol.74 , pp. 1265-1270
    • Uchiba, M.1    Okajima, K.2    Murakami, K.3    Nawa, K.4    Okabe, H.5    Takatsuki, K.6
  • 38
    • 0030014232 scopus 로고    scopus 로고
    • The effects of recombinant human thrombomodulin on endotoxin-induced multiple-system organ failure in rats
    • Hasegawa N, Kandra TG, Husari AW, et al. The effects of recombinant human thrombomodulin on endotoxin-induced multiple-system organ failure in rats. Am J Respir Crit Care Med. 1996;153:1831-1837.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1831-1837
    • Hasegawa, N.1    Kandra, T.G.2    Husari, A.W.3
  • 39
    • 0030658104 scopus 로고    scopus 로고
    • rhs-TM prevents ET-induced increase in pulmonary vascular permeability through protein C activation
    • Uchiba M, Okajima K, Murakami K, et al. rhs-TM prevents ET-induced increase in pulmonary vascular permeability through protein C activation. Am J Physiol. 1997;273:L889-L894.
    • (1997) Am J Physiol , vol.273
    • Uchiba, M.1    Okajima, K.2    Murakami, K.3
  • 40
    • 0030034186 scopus 로고    scopus 로고
    • Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
    • Murakami K, Okajima K, Uchiba M, et al. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood. 1996;87:642-647.
    • (1996) Blood , vol.87 , pp. 642-647
    • Murakami, K.1    Okajima, K.2    Uchiba, M.3
  • 41
    • 0032519883 scopus 로고    scopus 로고
    • Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes
    • Taoka Y, Okajima K, Uchiba M, et al. Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes. J Neurosci. 1998;18:1393-1398.
    • (1998) J Neurosci , vol.18 , pp. 1393-1398
    • Taoka, Y.1    Okajima, K.2    Uchiba, M.3
  • 42
    • 0036719075 scopus 로고    scopus 로고
    • The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogenactivated protein kinase pathways
    • Conway EM, Van de Wouwer M, Pollefeyt S, et al. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogenactivated protein kinase pathways. J Exp Med. 2002;196:565-577.
    • (2002) J Exp Med , vol.196 , pp. 565-577
    • Conway, E.M.1    Van De Wouwer, M.2    Pollefeyt, S.3
  • 43
    • 0029044322 scopus 로고
    • Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor
    • Bajzar L, Manuel R, Nesheim ME. Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. J Biol Chem. 1995;270:14477-14484.
    • (1995) J Biol Chem , vol.270 , pp. 14477-14484
    • Bajzar, L.1    Manuel, R.2    Nesheim, M.E.3
  • 44
    • 2942755757 scopus 로고    scopus 로고
    • Thrombin activatable fibrinolysis inhibitor: Not just an inhibitor of fibrinolysis
    • Bajzar L, Jain N, Wang P, Walker JB. Thrombin activatable fibrinolysis inhibitor: not just an inhibitor of fibrinolysis. Crit Care Med. 2004;32:S320-S324.
    • (2004) Crit Care Med , vol.32
    • Bajzar, L.1    Jain, N.2    Wang, P.3    Walker, J.B.4
  • 45
    • 0022910521 scopus 로고
    • Mechanism of protein C-dependent clot lysis: Role of plasminogen activator inhibitor
    • Sakata Y, Loskutoff DJ, Gladson CL, Hekman CM, Griffin JH. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood. 1986;68:1218-1223.
    • (1986) Blood , vol.68 , pp. 1218-1223
    • Sakata, Y.1    Loskutoff, D.J.2    Gladson, C.L.3    Hekman, C.M.4    Griffin, J.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.