Cystic fibrosis gene mutation (ΔF508) is associated with an intrinsic abnormality in Ca2+-induced arachidonic acid release by epithelial cells

DNA and Cell Biology

Volumn 16, Issue 6, 1997, Pages 749-759

  Miele, Lucio ^a   Cordella Miele, Eleonora ^a   Xing, Mingzhao ^a   Frizzell, Raymond ^a   Mukherjee, Anil B ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; IBUPROFEN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CALCIUM TRANSPORT; CYSTIC FIBROSIS; DRUG MEGADOSE; GENE MUTATION; GENETIC LINKAGE; HUMAN; HUMAN CELL; INFLAMMATION; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM;

EID: 0030946894     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.1997.16.749     Document Type: Article

References (4)

1. ANDERSON, M.P., and WELSH, M.J. (1990). Fatty acids inhibit apical membrane chloride channels in airway epithelia. Proc. Natl. Acad. Sci. USA 87, 7334-7338.
2. ANDERSON, M.P., RICH, D.P., GREGORY, R.J., SMITH, A.E., and WELSH, M.J. (1991a). Generation of cAMP activated chloride currents by expression of CFTR. Science 251, 679-682.
3. ANDERSON, M.P., GREGORY, R.J., and THOMPSON, S. (1991b). Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 253, 202-205.
4. ARISPE, N., ROJAS, E., HARTMAN, J., SORSCHER, E.J., and POLLARD, H.B. (1992). Intrinsic anion channel activity of the recombinant first nucleotide binding fold domain of the cystic fibrosis transmembrane regulator protein. Proc. Natl. Acad. Sci. USA 89, 1539-1543.