Ontogeny and nutritional programming of adiposity in sheep: Potential role of glucocorticoid action and uncoupling protein-2

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 289, Issue 5 58-5, 2005, Pages

  Gnanalingham, Muhuntha G ^a   Mostyn, Alison ^a   Symonds, Michael E ^a,b   Stephenson, Terence ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Adipose tissue; Glucocorticoids; Mitochondria

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID; MESSENGER RNA; UNCOUPLING PROTEIN 2;

ADAPTATION; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIRTH; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DIETARY INTAKE; FEMALE; FETUS; GESTATIONAL AGE; HORMONE ACTION; INFLAMMATION; MATERNAL NUTRITION; NONHUMAN; OBESITY; ONTOGENY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; PROTEIN FUNCTION; RISK FACTOR; SHEEP;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; ANIMALS, NEWBORN; BODY SIZE; FEMALE; FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; GLUCOCORTICOIDS; ION CHANNELS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; OBESITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL NUTRITION PHYSIOLOGY; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SHEEP, DOMESTIC;

EID: 27144511493     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00375.2005     Document Type: Article

References (49)

1. Agricultural Research Council. Nutrient Requirements of Ruminant Livestock. London: Commonwealth Agricultural Bureau, 1980.
2. 1a. Andrews RC, Herlihy O, Livingstone DEW, Andrew R, and Walker BR. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. J Clin Endocrinol Metab 87: 5587-5593, 2002.
3. Andrews RC, Rooyackers O, and Walker BR. Effects of 11beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab 88: 285-291, 2003.
4. Bamberger CM, Schulte HM, and Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17: 245-261, 1996.
5. Barker DJP. Mothers, Babies and Disease in Later Life (2nd ed.). Edinburgh: Churchill Livingstone, 1998.
6. Barker DJP, Gluckman PD, Godfrey KM, Harding JE, Owens JA, and Robinson JS. Fetal nutrition and cardiovascular disease in later life, Lancet 341: 938-941, 1993.
7. Bauer MK, Breier BH, Harding J, Veldhuis JD, and Gluckman PD. The fetal somatotrophic axis during long-term maternal undernutrition in sheep; evidence of nutritional regulation in utero. Endocrinology 136: 1250-1257, 1995.
8. Bispham J, Budge H, Mostyn A, Dandrea J, Clarke L, Keisler D, Symonds ME, and Stephenson T. Ambient temperature, maternal dexamethasone, and postnatal ontogeny of leptin in the neonatal lamb. Pediatr Res 52: 85-90, 2002.
9. Bispham J, Gopalakrishnan GS, Dandrea J, Wilson V, Budge II, Keisler DH, Broughton Pipkin F, Stephenson T, and Symonds ME. Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development. Endocrinology 144: 3575-3585, 2003.
10. Boss O, Hagen T, and Lowell BB. Uncoupling proteins 2 and 3, potential regulators of mitochondrial energy metabolism. Diabetes 49: 143-156, 2000.
11. Boullu-Ciocca S, Dutour A, Guillaume V, Achard V, Oliver C, and Grino M. Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood. Diabetes 54: 197-203, 2005.
12. Boullu-Ciocca S, Paulmyer-Lacroix O, Fina F, Ouafik LH, Alessi MC, Oliver C, and Grino M. Expression of the mRNAs coding for the glucocorticoid receptor isoforms in obesity. Obes Res 11: 925-929, 2003.
13. Bujalska IW, Kumar S, and Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet 394: 1210-1213, 1997.
14. Cassell PG, Neverova M, Janmohamed S, Uwakwe N, Qureshi A, McCarthy MI, Saker PJ, Albon L, Kopelman P, Noonan K, Easlick J, Ramachandran A, Snehalatha C, Pecqueur C, Ricquier D, Warden C, and Hitman GA. An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes. Diabetologia 42: 688-692, 1999.
15. Clarke L, Bryant MJ, Lomax MA, and Symonds ME. Maternal manipulation of brown adipose tissue and liver development in the ovine fetus during late gestation. Br J Nutr 77: 871-883, 1997.
16. Clarke L, Buss DS, Juniper DS, Lomax MA, and Symonds ME. Adipose tissue development during early postnatal life in ewe-reared lambs. Exp Physiol 82: 1015-1017, 1997.
17. Clarke L, Heasman L, Juniper DT, and Symonds ME. Maternal nutrition in early-mid gestation and placental size in sheep. Br J Nutr 79: 359-364, 1998.
18. De Kloet ER, Vreugdenhil E, Oitzl MS, and Joels M. Brain corticosteroid receptor balance in health and disease. Endocr Res 74: 269-301, 1998.
19. Edwards LJ and McMillen IC. Maternal undernutrition increases arterial blood pressure in the sheep fetus during late gestation. J Physiol 533: 561-570, 2001.
20. Engeli S, Bohnke J, Feldpausch M, Gorzelniak K, Heintze U, Janke J, Luft FC, and Sharma AM. Regulation of 11β-HSD genes in human adipose tissue: influence of central obesity and weight loss. Obes Res 12: 9-17, 2004.
21. Eriksson JG, Forsen T, Tuomilehto J, Osmond C, and Barker DJP. Early growth and coronary heart disease in later life: longitudinal study. Br Med J 322: 949-953, 2001.
22. Fleury C, Neverova M, Collins S, Pecquer C, Raimbault S, Champigny O, Meyrueis C, Bouillaud F, Seldin MF, Surwit R, Ricquier D, and Warden C. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15: 269-272, 1997.
23. Gaillard D, Wabitsch M, Pipy B, and Negrel R. Control of terminal differentiation of adipose precursor cells by glucocorticoids. J Lipid Res 32: 569-579, 1991.
24. Gardner DS, Pearce S, Stephenson T, and Symonds ME. Maternal diet and development of regional adiposity in sheep (Abstract). Proc Nutr Soc 63: OC120A, 2005.
25. Gardner DS, Tingey K, Van Bon BWM, Ozanne SE, Wilson V, Dandrea J, Keisler DH, Stephenson T, and Symonds ME. Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition. Am J Physiol Regul Integr Comp Physiol 289: R947-R954, 2005.
26. Gnanalingham MG, Mostyn A, Dandrea J, Yakubu DP, Symonds ME, and Stephenson T. Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung. J Physiol 565: 159-169, 2005.
27. Jessop DS, Dallman MF, Fleming D, and Lightman SL. Resistance to glucocorticoid feedback in obesity. J Clin Endocrinol Metab 86: 4109-4114, 2001.
28. Joyner JM, Hutley LJ, and Cameron DP. Glucocorticoid receptors in human preadipocytes: regional and gender differences. J Endocrinol 166: 145-152, 2000.
29. Kissebah AH and Krakower GR. Regional adiposity and morbidity. Physiol Res 74: 761-811, 1994.
30. Kizaki T, Suzuki K, Hitomi Y, Taniguchi N, Saitoh D, Watanabe K, Onoe K, Day NK, Good RA, and Ohno H. Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA 99: 9392-9397, 2002.
31. Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CRW, Seckl JR, and Mullins JJ. 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 94: 14924-14929, 1997.
32. Masaki T, Yoshimatsu H, Kakuma T, Chiba S, Hidaka S, Tajima D, Kurokawa M, and Sakata T. Induction of rat uncoupling protein-2 gene treated with tumour necrosis factor alpha in vivo. Eur J Clin Invest 29: 76-82, 1999.
33. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, and Flier JS. A transgenic model of visceral obesity and the metabolic syndrome. Science 294: 2166-2170, 2001.
34. Mostyn A, Wilson V, Dandrea J, Yakubu DP, Budge H, Alves-Guerra MC, Pecqueur C, Miroux B, Symonds ME, and Stephenson T. Ontogeny and nutritional manipulation of mitochondrial protein abundance in adipose tissue and the lungs of postnatal sheep. Br J Nutr 90: 323-328, 2003.
35. Negre-Salvayre A, Hirtz C, Carrera G, Cazenave R, Troly M, Salvayre R, Penicaud L, and Casteilla L. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB 711: 809-815, 1997.
36. Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, and Grino M. Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: An in situ hybridization study. J Clin Endocrinol Metab 87: 2701-2705, 2002.
37. Prins JB and O'Rahilly S. Regulation of adipose cell number in man. Clin Sci (Lond) 92: 3-11, 1997.
38. Rask E, Walker BR, Soderberg S, Livingstone DEW, Eliasson M, Johnson O, Andrew R, and Olsson T. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 87: 3330-3336, 2002.
39. Rebuffe-Scrive M, Krotkiewski M, Elfverson J, and Bjorntorp P. Muscle and adipose tissue morphology and metabolism in Cushing's syndrome. J Clin Endocrinol Metab 67: 1122-1128, 1988.
40. Roseboom TJ, van der Meulen JHP, Osmond C, Barker DJP, Ravelli ACJ, and Blecker OP. Plasma lipid profile in adults after perinatal exposure to famine. Am J Clin Nutr 72: 1101-1106, 2000.
41. Stewart PM, and Krozowski ZS. Hydroxysteroid dehydrogenase. Vitam Horm 57: 249-324, 1999.
42. Symonds ME, Bird JA, Clarke L, Gate JJ, and Lomax MA. Nutrition, temperature and homeostasis during perinatal development. Exp Physiol 80: 907-940, 1995.
43. Symonds ME, Phillips ID, Anthony RV, Owens JA, and McMillen IC. Prolactin receptor gene expression and foetal adipose tissue. J Neuroendocrinol 10: 885-890, 1998.
44. Wake DJ and Walker BR. 11β-Hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome. Mol Cell Endocrinol 215: 45-54, 2004.
45. Walker BR. 11β-hydroxysteroid dehydrogenase type 1 in obesity. Obes Res 12: 1-3, 2004.
46. Walker BR, Connacher AA, Lindsay RM, Webb DJ, and Edwards CRW. Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 80: 3155-3159, 1995.
47. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, and Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808, 2003.
48. Whorwood CB, Firth KM, Budge H, and Symonds ME. Maternal undernutrition during early- to mid-gestation programmes tissue-specific alterations in the expression of the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase isoforms and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 142: 2854-2864, 2001.
49. Yuen BSJ, Owens PC, McFarlane J, Symonds ME, Edwards LJ, Kauter KG, and McMillen IC. Circulating leptin concentrations are positively related to leptin mRNA expression in fetus adipose tissue in the pregnant ewe fed at or below maintenance energy requirements during late gestation. Biol Reprod 67: 911-916, 2002.