Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain

Nuclear Medicine and Biology

Volumn 32, Issue 8, 2005, Pages 837-844

  Matsuya, Takahiro ^a,b   Takamatsu, Hiroyuki ^a,b   Murakami, Yoshihiro ^a,b   Noda, Akihiro ^a,b   Ichise, Rikiya ^a   Awaga, Yuji ^a   Nishimura, Shintaro ^a,b  

^a Medical and Pharmacological Research Center Foundation   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Adenosine A1 receptor antagonist; FR194921; Monkey; Positron emission tomography

Indexed keywords

2 (1 METHYL 4 PIPERIDINYL) 6 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 3(2H) PYRIDAZINONE C 11; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR ANTAGONIST; CARBON 11; FR 194921; TRACER; UNCLASSIFIED DRUG; 2 (1 METHYL 4 PIPERIDINYL) 6 (2 PHENYLPYRAZOLO(1,5 A)PYRIDIN 3 YL) 3(2H) PYRIDAZINONE; 2-(1-METHYL-4-PIPERIDINYL)-6-(2-PHENYLPYRAZOLO(1,5-A)PYRIDIN-3-YL)-3(2H)-PYRIDAZINONE; ADENOSINE A1 RECEPTOR; CARBON; DIAGNOSTIC AGENT; PIPERIDINE DERIVATIVE; PYRIDAZINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; XANTHINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN REGION; CALCULATION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG SCREENING; DRUG SYNTHESIS; HIPPOCAMPUS; IMAGING; LIGAND BINDING; MALE; MONKEY; NONHUMAN; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; RAT; RAT STRAIN; THALAMUS; ANIMAL; ANTIBODY SPECIFICITY; CHEMISTRY; DRUG ANTAGONISM; EVALUATION; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; SCINTISCANNING; SPRAGUE DAWLEY RAT; STAINING; SYNTHESIS; TISSUE DISTRIBUTION; WHOLE BODY IMAGING;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; MALE; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; PYRIDAZINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A1; STAINING AND LABELING; TISSUE DISTRIBUTION; WHOLE BODY IMAGING; XANTHINE;

EID: 27144482990     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2005.06.008     Document Type: Article

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